ID W5N2X7_LEPOC Unreviewed; 239 AA.
AC W5N2X7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=E3 ubiquitin-protein ligase RNF138 {ECO:0000256|ARBA:ARBA00039332};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
DE AltName: Full=RING finger protein 138 {ECO:0000256|ARBA:ARBA00041652};
DE AltName: Full=RING-type E3 ubiquitin transferase RNF138 {ECO:0000256|ARBA:ARBA00041476};
GN Name=RNF138 {ECO:0000313|Ensembl:ENSLOCP00000014986.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000014986.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000014986.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
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DR RefSeq; XP_006643276.1; XM_006643213.2.
DR AlphaFoldDB; W5N2X7; -.
DR STRING; 7918.ENSLOCP00000014986; -.
DR Ensembl; ENSLOCT00000015015.1; ENSLOCP00000014986.1; ENSLOCG00000012186.1.
DR GeneID; 102698592; -.
DR KEGG; loc:102698592; -.
DR eggNOG; ENOG502RB47; Eukaryota.
DR GeneTree; ENSGT00950000182909; -.
DR HOGENOM; CLU_092448_1_0_1; -.
DR InParanoid; W5N2X7; -.
DR OMA; CFNEEDF; -.
DR OrthoDB; 26661at2759; -.
DR Proteomes; UP000018468; Unassembled WGS sequence.
DR Bgee; ENSLOCG00000012186; Expressed in intestine and 10 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0000209; P:protein polyubiquitination; IBA:GO_Central.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR CDD; cd16544; RING-HC_RNF138; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR008598; Di19_Zn-bd.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46968; E3 UBIQUITIN-PROTEIN LIGASE RNF138; 1.
DR PANTHER; PTHR46968:SF2; E3 UBIQUITIN-PROTEIN LIGASE RNF138; 1.
DR Pfam; PF13923; zf-C3HC4_2; 1.
DR Pfam; PF05605; zf-Di19; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 28..68
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 239 AA; 26788 MW; 74D408FACC51371A CRC64;
MGSAEEEGAR PPAEEPFSDL DLSGDFDCPI CQEVFKTPIR TKTCKHVFCK HCFVAAVRAC
GPHCPMCRGP VSEDEKRATD VARRMRTRRG RCRACGSCSV FSQMRRHYKY CRKYREEYGN
PVVPRAQGTV SGGAQSTATI SMSMTYSCPY CQQPGLSDMS LVQHCRGNHV GNPAPVVCPI
CAATSWGNPS YYSTNFIGHL NQRHRFSYDN YTNTRVDEDA LFHLAVEQSV RHSLQNNQL
//
