ID W5N3F6_LEPOC Unreviewed; 979 AA.
AC W5N3F6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Vacuolar protein sorting-associated protein 18 homolog {ECO:0000256|ARBA:ARBA00017338};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000015165.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000015165.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Late endosome membrane
CC {ECO:0000256|ARBA:ARBA00004492}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004492}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004492}. Lysosome membrane
CC {ECO:0000256|ARBA:ARBA00004630}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004630}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004630}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the VPS18 family.
CC {ECO:0000256|ARBA:ARBA00010454}.
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DR EMBL; AHAT01019064; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006632494.1; XM_006632431.2.
DR AlphaFoldDB; W5N3F6; -.
DR STRING; 7918.ENSLOCP00000015165; -.
DR Ensembl; ENSLOCT00000015194.1; ENSLOCP00000015165.1; ENSLOCG00000012325.1.
DR GeneID; 102686954; -.
DR KEGG; loc:102686954; -.
DR CTD; 57617; -.
DR eggNOG; KOG2034; Eukaryota.
DR GeneTree; ENSGT00940000153635; -.
DR HOGENOM; CLU_003488_1_0_1; -.
DR InParanoid; W5N3F6; -.
DR OMA; WIQREKW; -.
DR OrthoDB; 22879at2759; -.
DR Proteomes; UP000018468; Linkage group LG7.
DR Bgee; ENSLOCG00000012325; Expressed in muscle tissue and 13 other cell types or tissues.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0030897; C:HOPS complex; IBA:GO_Central.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IBA:GO_Central.
DR GO; GO:0045176; P:apical protein localization; IEA:Ensembl.
DR GO; GO:0015721; P:bile acid and bile salt transport; IEA:Ensembl.
DR GO; GO:0007032; P:endosome organization; IBA:GO_Central.
DR GO; GO:0008333; P:endosome to lysosome transport; IBA:GO_Central.
DR GO; GO:0043485; P:endosome to pigment granule transport; IEA:Ensembl.
DR GO; GO:0048069; P:eye pigmentation; IEA:Ensembl.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0007040; P:lysosome organization; IBA:GO_Central.
DR GO; GO:0060036; P:notochord cell vacuolation; IEA:Ensembl.
DR GO; GO:0007634; P:optokinetic behavior; IEA:Ensembl.
DR GO; GO:0048284; P:organelle fusion; IBA:GO_Central.
DR GO; GO:0006904; P:vesicle docking involved in exocytosis; IBA:GO_Central.
DR CDD; cd16689; RING-H2_Vps18; 1.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR007810; Pep3_Vps18.
DR PANTHER; PTHR23323; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR23323:SF26; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG; 1.
DR Pfam; PF05131; Pep3_Vps18; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50236; CHCR; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 46..440
FT /note="Pep3/Vps18/deep orange beta-propeller"
FT /evidence="ECO:0000259|Pfam:PF05131"
FT REGION 911..935
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 807..855
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 915..929
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 979 AA; 113590 MW; 3C0FCD2CCFCF99DE CRC64;
MASILDEYED SQSIRHSMQK TTRLSASNIG ITHSGFVNAR LEEEKPIFNK QRIDFSPPEK
INHFAVCNNQ LCMSLGKDTL LRIDLGKPDQ PNQVELGRKD EAKVHKLFLD PTGAHLVISL
TSSECLYLNR NTQKVRSLSR WKGHLIESIA WNKLLGTETN TGPILAGTTQ GLIFEAEISA
SEGASLFNTN PDQYFRQVHM LEEDGKPAPV CCLEIDRGFE SKYFIIATTR KRLFQFVGKV
AEGAEQQGFS SIFSQNQDHF PSFQEFPVSM GYSEIAFYTP KLRTSPKSFA WMMGNGVLYG
NLDYGRPDSL LSDVEVWEYT PDIDFKFNKP ISIVLTQFHF LLLLPDRVKA VCTLNGQVVY
EDVFPDKFGP LKRMIKDPVG SLVWIYTEKA VFRYHIQREA RDVWQMYMSM NKFDRAKEYC
RDRPECMDIV LAKEAEHCFQ NKKYLESAKC YALTQNYFEE IALKFIEAKQ EEALKEFLIK
KLSILKSSEK TQITLLVTWL TELYLNRLGI LEGDELKRVT FLEAREEFRK FLSSPKNKEC
LYNNRTTIYD LLASHGNVDD MVYFSVIMQD YERVVSHYCQ HDDYEAALDV LSKHADEKLF
YKFSPVLMQH IPKKVVDAWI KMGKKLDAKQ LIPALVNYSQ IGSTEQINET IRYMEFCVYE
VTVTEEAIHN YLLSLYAKYK PECLLWYLEQ AGTHSSEIHY DLKYALRLFA EHGHRQACVH
VYKIMELYEE AVDLALQVDV DLAKSCADLP EDDEELRKKL WLKIARHVVQ EEKDVKKAMN
CLSSCNLLKI EDILPFFPDF VTIDHFKEAI CNSLEEYNKH IEELKQEMEE ATESAKRIRE
DIQEMRNKYG VVESQEKCAA CDFPLLNRPF YLFLCSHMFH YDCLLQEVNP HLSTYKLTKL
EELQKKLLAT SQPTKARHRQ KEEDTISLGK GQPSREQIKS DIDDIIAAEC VYCGELMIKS
IDKPFIDPQK YEDEKSSWL
//
