ID W5N5Q3_LEPOC Unreviewed; 706 AA.
AC W5N5Q3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=NOP2/Sun RNA methyltransferase family member 7 {ECO:0000313|Ensembl:ENSLOCP00000015962.1};
GN Name=NSUN7 {ECO:0000313|Ensembl:ENSLOCP00000015962.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000015962.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000015962.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. RsmB/NOP family. {ECO:0000256|PROSITE-ProRule:PRU01023}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01023}.
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DR EMBL; AHAT01001958; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01001959; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01001960; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01001961; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01001962; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_015201466.1; XM_015345980.1.
DR RefSeq; XP_015201467.1; XM_015345981.1.
DR AlphaFoldDB; W5N5Q3; -.
DR Ensembl; ENSLOCT00000015992.1; ENSLOCP00000015962.1; ENSLOCG00000012956.1.
DR GeneID; 102696834; -.
DR KEGG; loc:102696834; -.
DR CTD; 79730; -.
DR GeneTree; ENSGT00940000157352; -.
DR HOGENOM; CLU_023514_0_0_1; -.
DR OrthoDB; 5312486at2759; -.
DR Proteomes; UP000018468; Linkage group LG4.
DR Bgee; ENSLOCG00000012956; Expressed in testis and 8 other cell types or tissues.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR049560; MeTrfase_RsmB-F_NOP2_cat.
DR InterPro; IPR001678; MeTrfase_RsmB-F_NOP2_dom.
DR InterPro; IPR049561; NSUN5_7_fdxn-like.
DR InterPro; IPR042620; NSUN7.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR14663:SF2; METHYLTRANSFERASE NSUN7-RELATED; 1.
DR PANTHER; PTHR14663; UNCHARACTERIZED; 1.
DR Pfam; PF01189; Methyltr_RsmB-F; 1.
DR Pfam; PF21148; NSUN5_fdxn-like; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51686; SAM_MT_RSMB_NOP; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01023}; Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU01023};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01023};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01023}.
FT DOMAIN 193..505
FT /note="SAM-dependent MTase RsmB/NOP-type"
FT /evidence="ECO:0000259|PROSITE:PS51686"
FT REGION 531..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 590..640
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 620..639
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 436
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
SQ SEQUENCE 706 AA; 78059 MW; 925331926FC600EA CRC64;
MEPRSQSPEI GAEISSFGDL SISHKVDPSK KSPAVSAESG GYPDYVYVHA AAIFFTIHVE
KPVDRRLVRY GDQISFSVPE AKNEIAQHYA HELAFNALKY QDLLEDIMID SCFYLSQSIP
DDLTSLVVVM LYDFQDRKFL PRACPEEEEI EEVRDVEKCL LRYRTKLAAA LARCRIKHNL
LTIDYILPES VRKKQERAST LPLYAWVNTM KTSLEDVCCT LEKEGFSEVK SISQLGGLTF
CLDPHCQDLL VFPPHLKADL YRTKLLTEYK LIIQDKSRSL AAHSVKALLT DDDDVIMANL
TSGYTIAHMA ALSTLSTGRV WVCGVSQARE ELQEILSHME CKNVKLLPES FTDIEPTDPR
LQKAKVILVM PQCSATGVSN PVEFILNDSG DAGLLQDLCQ GSISEDKLNT LVRQQLQDLI
HAVKFPKAQA VVYCTCSVHP EENEGVVRKA LLFKPEGTKA QPYRLSPPVL PLCCMSEVDN
ARENYFRLGP CERANGCFIA VLTREDSSQT VTVKDVLARA AAKGLLEGID TGKPAKKERR
KAKASVLPSS SASASQARIA EFLSRERKTT SSSSSLLLPA KACTSSHALL RAGQRARTPK
PTPSSLPAKK NGSKPPPAGR PPERRAHPPR ARPEERASAL KPVELVLPPV MFPGCGQSRS
PLPLSFFRWK GTSGHSQTSL SPSSLSVSRH REALRSGVVL HPRPWL
//
