ID W5NE19_LEPOC Unreviewed; 452 AA.
AC W5NE19;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Bone morphogenetic protein 10 {ECO:0000313|Ensembl:ENSLOCP00000018878.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000018878.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000018878.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; AHAT01006094; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006625612.2; XM_006625549.2.
DR AlphaFoldDB; W5NE19; -.
DR STRING; 7918.ENSLOCP00000018878; -.
DR Ensembl; ENSLOCT00000018910.1; ENSLOCP00000018878.1; ENSLOCG00000015342.1.
DR GeneID; 102688423; -.
DR KEGG; loc:102688423; -.
DR CTD; 27302; -.
DR eggNOG; KOG3900; Eukaryota.
DR GeneTree; ENSGT00940000156279; -.
DR HOGENOM; CLU_020515_2_0_1; -.
DR InParanoid; W5NE19; -.
DR OMA; SAQNKHD; -.
DR OrthoDB; 2912454at2759; -.
DR Proteomes; UP000018468; Linkage group LG1.
DR Bgee; ENSLOCG00000015342; Expressed in heart and 2 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0030509; P:BMP signaling pathway; IBA:GO_Central.
DR CDD; cd13767; TGF_beta_BMP9_like; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF39; BONE MORPHOGENETIC PROTEIN 10; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..452
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004867612"
FT DOMAIN 340..452
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 178..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 452 AA; 51971 MW; 4C267CBB0367E634 CRC64;
MDTVRLRSLV ALWLLIHSGC CSPIMAPEDP RPAMGMDRHN LFGDPLLEQD SELDFQTFVQ
TIREQFLKTF NLSGFPQQDA TKVEPPEYML QLYNKFANDR SSMPSGNIVR SFKNEDTSSY
SMDISGIRKH PLLFNVSIPH HERITMAELR LYTLVQRDRR LYEGVDRKVT IYEVREGRQE
KKEGQEPERR AGGERVGREE KLVELASRQV FGTDSSWEAF DLTEATRHWR KLDYTTHRLE
VHIQSVNDMG GEAYEGGNLD IDINPEAKHE PLLIVFSDDQ SGDHKEEKKE LNEMIGHEQP
LELENLEMDL NGLGEDGEEG PNEESLIQMR SNLIYDTASR IRRNAKGNHC KKTSFYVEFK
DIGWDTWILA PTGYEAYECN GMCTYPMTEH VSPTKHAIVR TLVHMRSPQK VSRACCVPTK
LDPISLLYMD DTGVVTYKYK YEGMVVAECG CR
//
