ID W5NEF4_LEPOC Unreviewed; 358 AA.
AC W5NEF4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Solute carrier family 25 member 3 {ECO:0000256|ARBA:ARBA00024242};
DE AltName: Full=Phosphate carrier protein, mitochondrial {ECO:0000256|ARBA:ARBA00035382};
DE AltName: Full=Phosphate transport protein {ECO:0000256|ARBA:ARBA00031327};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000019013.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000019013.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+)(in) + phosphate(in) = H(+)(out) + phosphate(out);
CC Xref=Rhea:RHEA:29939, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474;
CC Evidence={ECO:0000256|ARBA:ARBA00035091};
CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:29941;
CC Evidence={ECO:0000256|ARBA:ARBA00035091};
CC -!- SUBUNIT: Interacts with PPIF; the interaction is impaired by CsA.
CC {ECO:0000256|ARBA:ARBA00024212}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004448}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000256|ARBA:ARBA00006375, ECO:0000256|RuleBase:RU000488}.
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DR EMBL; AHAT01026415; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006633233.1; XM_006633170.2.
DR AlphaFoldDB; W5NEF4; -.
DR STRING; 7918.ENSLOCP00000019013; -.
DR Ensembl; ENSLOCT00000019045.1; ENSLOCP00000019013.1; ENSLOCG00000015447.1.
DR GeneID; 102698692; -.
DR KEGG; loc:102698692; -.
DR CTD; 322362; -.
DR eggNOG; KOG0767; Eukaryota.
DR GeneTree; ENSGT00390000008708; -.
DR HOGENOM; CLU_039456_3_1_1; -.
DR InParanoid; W5NEF4; -.
DR OMA; KFFFFEY; -.
DR OrthoDB; 5472853at2759; -.
DR Proteomes; UP000018468; Linkage group LG8.
DR Bgee; ENSLOCG00000015447; Expressed in heart and 13 other cell types or tissues.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005315; F:inorganic phosphate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:1990547; P:mitochondrial phosphate ion transmembrane transport; IEA:InterPro.
DR GO; GO:0035435; P:phosphate ion transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR InterPro; IPR044677; SLC25A3/Pic2/Mir1-like.
DR PANTHER; PTHR45671:SF10; PHOSPHATE CARRIER PROTEIN, MITOCHONDRIAL; 1.
DR PANTHER; PTHR45671; SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00282};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000488}.
FT TRANSMEM 259..280
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 311..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 59..143
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 156..240
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 257..335
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
SQ SEQUENCE 358 AA; 40077 MW; 81047C785269B6AA CRC64;
MYPTTLTQLA RANPFCAPLF TLQKAEEPRH SPAEQGHSRR RLAAAAVSDE VSCDFGSMKY
YALCGFGGIL SCGITHTAVV PLDLVKCRLQ VNPDKYKSIF KGFSITVRED GMRGLAKGWA
PTFIGYSMQG LCKFGFYEVF KIFYSNLMGE ENTYMWRTSL YLAASASAEF FADIALAPME
AVKVRIQTQP GYANTLRECV PKMYAEEGLW AFYKGVVPLW MRQIPYTMMK FACFERTVEA
LYKFVVPKPR SECSKSEQLV VTFVAGYIAG VFCAIVSHPA DSVVSVLNKE KGSTALQVLK
RLGLRGVWKG LVARIIMIGT LTALQWFIYD SVKVYFRLPR PPPPEMPESL KKKLGLAE
//
