ID W5NGP2_LEPOC Unreviewed; 411 AA.
AC W5NGP2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Nodal homolog 2-A-like {ECO:0000313|Ensembl:ENSLOCP00000019801.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000019801.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000019801.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; AHAT01008500; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5NGP2; -.
DR STRING; 7918.ENSLOCP00000019801; -.
DR Ensembl; ENSLOCT00000019834.1; ENSLOCP00000019801.1; ENSLOCG00000016070.1.
DR eggNOG; KOG3900; Eukaryota.
DR GeneTree; ENSGT00940000163919; -.
DR HOGENOM; CLU_020515_1_1_1; -.
DR InParanoid; W5NGP2; -.
DR OMA; EHKHHAN; -.
DR Proteomes; UP000018468; Linkage group LG1.
DR Bgee; ENSLOCG00000016070; Expressed in pharyngeal gill and 4 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd13759; TGF_beta_NODAL; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF159; NODAL HOMOLOG; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 279..411
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 202..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 273..308
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 273..288
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 411 AA; 46281 MW; 15B85E96F8EA12B6 CRC64;
MYGVEVHPTL DGNSSVSNAA VAPALRHRGS QHKSRYPRYM MHLYRSVKSA GRVAAAAAAA
GQAEDNPVLK ESNSVLSLVA KSCHQIGDKW SVTFDMSSIS ADDDVQLSEL RFRLPSFSAS
KRVTVEIFHS REQECAEESD SQPCQDRLFL GSFSASPADT NSSWKIFNVT ALLKYWLHQG
ESFVNGEGAA VIGDPLHEVP EEEHKERLEQ GQEHKHHANS TESSSERKVY HKTVDRVMMV
VFSKHNHSRE ETGMPTLIHT VEHSKYITLD KAVDQSGRRQ KRNRNGQERV KLAGNVGGTA
PTPESPQSPL CRKVDMWVDF DQIGWNQWIV HPKRYNAFRC EGECPCPVDE TFNPTNHAYM
QSLVKLYHPD KVPSISCVPT RLGPLSMLYY ENGELVLRHH EEMMVEECGC H
//
