ID W5NPA5_LEPOC Unreviewed; 893 AA.
AC W5NPA5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=RNA binding motif protein 12 {ECO:0000313|Ensembl:ENSLOCP00000022464.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000022464.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000022464.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AHAT01024303; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006639710.1; XM_006639647.2.
DR RefSeq; XP_015220542.1; XM_015365056.1.
DR AlphaFoldDB; W5NPA5; -.
DR STRING; 7918.ENSLOCP00000022464; -.
DR Ensembl; ENSLOCT00000022505.1; ENSLOCP00000022464.1; ENSLOCG00000018363.1.
DR GeneID; 102692368; -.
DR KEGG; loc:102692368; -.
DR CTD; 10137; -.
DR eggNOG; KOG4307; Eukaryota.
DR GeneTree; ENSGT00940000160611; -.
DR HOGENOM; CLU_004368_1_0_1; -.
DR InParanoid; W5NPA5; -.
DR OMA; QEFCVYL; -.
DR OrthoDB; 5402241at2759; -.
DR Proteomes; UP000018468; Linkage group LG18.
DR Bgee; ENSLOCG00000018363; Expressed in embryo and 13 other cell types or tissues.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0043484; P:regulation of RNA splicing; IBA:GO_Central.
DR CDD; cd12512; RRM3_RBM12; 1.
DR CDD; cd12749; RRM4_RBM12; 1.
DR CDD; cd12751; RRM5_RBM12; 1.
DR Gene3D; 3.30.70.330; -; 5.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR034855; RBM12_RRM3.
DR InterPro; IPR034856; RBM12_RRM4.
DR InterPro; IPR034854; RBM12_RRM5.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR13976:SF88; FI22004P1; 1.
DR PANTHER; PTHR13976; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED; 1.
DR Pfam; PF00076; RRM_1; 4.
DR SMART; SM00360; RRM; 4.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 4.
DR PROSITE; PS50102; RRM; 4.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176}.
FT DOMAIN 308..383
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 440..517
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 555..632
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 817..893
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 94..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 389..434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 531..552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 718..816
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 114..137
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 389..404
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 405..434
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 536..552
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 718..747
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 893 AA; 94633 MW; 8A0C2493F7019DCC CRC64;
MAVVIRLQGL PIVAGTMDIR HFFSGLTIPD GGVHIVGGEH GEAFIVFATD EDARLGMMRT
GGTIKGSKVS LLLSSKTEMQ NMIELSRRRF ETGNLEAPAG NGSRPGPPAS SGGSGRGSLP
TTMQGFSSPT PSVVTTAAAS AHEPVGSKSI PTFSTASMST IPPSYSNNFS SPSLTMGSTM
TTAISTLNSV PPPMPPLPTL PSLPPMPSIP PMPVPPPVST LPPVPPSTPI PPVPPVPPIT
HMPPMSTMPP FNPGVPPPVG PVPSGLSGSG PPMSMGNPNH MFLGPMNPLG PLNPQAHLKP
PVVNPDELYV HLQGLPFSAT EMDVRDFFHG LGVDSVRLLR DHLGRSSGRA LAKFFMPQDA
FEALKRNAAM MGQRYVEISP ATERQWLASG GASSYSGGQG QSKHGSDHSD QDHHRRLRSS
SESPSGRDRA RSRSPHKQEF CVYLKGLPYE AENKQIFEFF KNLDIVEDSI YIAYGPNGRA
TGEGFVEFRN EMDYKAALGC HMQYMGSRFI QVHPITKKGM FEKIDVIRKR MQGTQQGDHK
TGSFEGGGDK SSSRSCAHIS NIPYNVSKKD VQLFLEGIQL FEDSLKVLVD GNGQGLGQAV
VQFRSEEEAL KAERLHRQKL NGRDAFVHLV TFEQMKEIER NPPPQVKRGQ KVQLPQAHSY
PSVSGDEYAF LRGSSGSITN GPPFGTLYSA PGNGLGGPPP LPPVGVGGGL GDVPISVPPP
VVPGHLPSPM LEPPGFRPGP SSTSGPPVFP GGPESMRGLP PFDNGPRKSS GPPSRGGAGG
GGQGRAGGSQ SGYGPPSSEA LRGPPSLSGG PGSQRPTIVK IQNMPFTVTV DEILDFFYGY
QVLPGSVCLQ FSDKGMPTGE AMVAFESQDE AMSAVLDLND RPIGSRKVKI TLG
//
