ID W5NTW0_SHEEP Unreviewed; 431 AA.
AC W5NTW0;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Ig-like domain-containing protein {ECO:0000259|PROSITE:PS50835};
GN Name=CADM1 {ECO:0000313|Ensembl:ENSOARP00000001604.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000001604.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000001604.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000001604.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000001604.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the nectin family.
CC {ECO:0000256|ARBA:ARBA00007810}.
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DR EMBL; AMGL01031369; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01031370; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01031371; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01031372; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5NTW0; -.
DR SMR; W5NTW0; -.
DR STRING; 9940.ENSOARP00000001604; -.
DR PaxDb; 9940-ENSOARP00000001604; -.
DR Ensembl; ENSOART00000001647.1; ENSOARP00000001604.1; ENSOARG00000001539.1.
DR eggNOG; ENOG502R1KU; Eukaryota.
DR HOGENOM; CLU_047574_2_1_1; -.
DR OMA; TYDRMYT; -.
DR Proteomes; UP000002356; Chromosome 15.
DR Bgee; ENSOARG00000001539; Expressed in pituitary gland and 54 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd05883; IgI_2_Necl-2; 1.
DR CDD; cd05881; IgV_1_Necl-2; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR003585; Neurexin-like.
DR PANTHER; PTHR45889:SF2; CELL ADHESION MOLECULE 1; 1.
DR PANTHER; PTHR45889; IG-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00294; 4.1m; 1.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 364..384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..100
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 105..199
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 204..278
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 431 AA; 47675 MW; 1487E8EDCD8CB65A CRC64;
MEGDGQNLFT KDVTVIEGEV ATISCQVNKS DDSVIQLLNP NRQTIYFRDF RPLKDSRFQL
LNFSSSELKV SLTNVSISDE GRYFCQLYTD PPQESYTTIT VLVPPRNLMI DIQKDTAVEG
EEIEVNCTAM ASKPATTIRW FKGNKELKGK SEVEEWSDMY TVTSQLMLKV HKEDDGVPVI
CQVEHPAVTG NLQTQRYLEV QYKPQVHIQM TYPLQGLTRE GDALELTCEA IGKPQPVMVT
WVRVDDEMPP HAVLSGPSLF INNLNKTDNG TYRCEASNIV GKAHSDYMLY VYDPPTTIPP
PTTTSTTTTT TTTILTIITD TTATTEPAVH GLTQLPNSAE ELDSEDLSDS RAGEEGAIRA
VDHAVIGGVV AVVVFAMLCL LIILGRYFAR HKGTYFTHEA KGADDAADAD TAIINAEGGQ
NNSEEKKEYF I
//
