ID W5NTY8_SHEEP Unreviewed; 705 AA.
AC W5NTY8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Rho GTPase-activating protein 22 {ECO:0008006|Google:ProtNLM};
GN Name=ARHGAP22 {ECO:0000313|Ensembl:ENSOARP00000001632.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000001632.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000001632.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000001632.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000001632.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AMGL01071973; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01071974; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01071975; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01071976; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01071977; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01071978; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01071979; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01071980; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01071981; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5NTY8; -.
DR SMR; W5NTY8; -.
DR STRING; 9940.ENSOARP00000001632; -.
DR PaxDb; 9940-ENSOARP00000001632; -.
DR Ensembl; ENSOART00000001675.1; ENSOARP00000001632.1; ENSOARG00000001560.1.
DR eggNOG; KOG4270; Eukaryota.
DR HOGENOM; CLU_020795_0_0_1; -.
DR OMA; MAVNHEA; -.
DR Proteomes; UP000002356; Chromosome 25.
DR Bgee; ENSOARG00000001560; Expressed in adrenal medulla and 51 other cell types or tissues.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd13378; PH_RhoGAP2; 1.
DR CDD; cd04390; RhoGAP_ARHGAP22_24_25; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR15228:SF22; RHO GTPASE-ACTIVATING PROTEIN 22; 1.
DR PANTHER; PTHR15228; SPERMATHECAL PHYSIOLOGY VARIANT; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 37..145
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 155..349
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 349..397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 410..457
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 476..515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 579..601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 628..690
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 479..493
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 494..515
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 705 AA; 77512 MW; 21FF5CE39225D1CF CRC64;
MLSPKIRQAR RARSKSLVMG EQSRSPGRPP CPRRLGPVLK AGWLKKQRSI MKGWQQRWFV
LRGDQLFYYK DKDETKPQGF ISLQGTQVTE LLPGPEDPGK HLFEISPGGA GEREKVPANP
EALLLMASSQ RDMEDWVQAI RRVIWAPFGR GVFGQRLEDT VHHERKSGPR LAPLLVEQCV
DFIRERGLTE EGLFRMPGQA NLVRDLQDSF DCGEKPLFDS TTDVHTVASL LKLYLRELPE
PVVPFSRYED FLSCAQLLTK DEGEGTLELA KQVSSLPLVN YNLLRYICKF LDEVQSHSDV
NKMSVQNLAT VFGPNILRPQ IEDPVAIMEG TSLVQQLMTV LIRKHSQLFT PRTTEGPASP
RGGPPCTVGW GSEEVPRDDQ AEPGSPSGPC LPSHRTSSLD GAAVAALSRT SPTGLGSRCS
PAATSPGKKV QTLPNWRSSF RQSGSRSGSP KVGTSSLEVP IISGGNWLMN GLSSLRGHRR
ASSGDRLKDS GSEQRLSTYD NVPPQSSFPS TPSVASLPWS GVSSCEASAR GSVSSCTACR
ASDSSACSSL HIEGALEPSP VLSSSEERRS LDLDHGLDGV GACISSSEPS DPGSPAQDHA
RRTEVLQGLV TELRAELCRQ RTEYETSVKR LEEGSADLRK RMSRLEEELD QEKKKYTMLE
IKLRNSERAR EDAEKRNQLL QREMEEFFST LGSLTVGAKG ARAPK
//
