ID W5NVB8_SHEEP Unreviewed; 1701 AA.
AC W5NVB8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Ig-like domain-containing protein {ECO:0000259|PROSITE:PS50835};
GN Name=SIGLEC1 {ECO:0000313|Ensembl:ENSOARP00000002114.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000002114.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000002114.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000002114.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000002114.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AMGL01025442; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9940.ENSOARP00000002114; -.
DR PaxDb; 9940-ENSOARP00000002114; -.
DR Ensembl; ENSOART00000002164.1; ENSOARP00000002114.1; ENSOARG00000002007.1.
DR eggNOG; KOG4475; Eukaryota.
DR HOGENOM; CLU_243945_0_0_1; -.
DR OMA; VTFNSQK; -.
DR Proteomes; UP000002356; Chromosome 13.
DR Bgee; ENSOARG00000002007; Expressed in ileocolic lymph node and 45 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00096; Ig; 5.
DR Gene3D; 2.60.40.10; Immunoglobulins; 17.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR013151; Immunoglobulin.
DR PANTHER; PTHR47243; SIALOADHESIN; 1.
DR PANTHER; PTHR47243:SF1; SIALOADHESIN; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF07679; I-set; 4.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF13895; Ig_2; 6.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 15.
DR SMART; SM00408; IGc2; 14.
DR SMART; SM00406; IGv; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 13.
DR PROSITE; PS50835; IG_LIKE; 14.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1701
FT /note="Ig-like domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004870295"
FT TRANSMEM 1627..1650
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 142..233
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 238..320
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 325..405
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 415..505
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 508..593
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 601..703
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 706..782
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 796..889
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 895..974
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 981..1080
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1082..1240
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1242..1324
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1428..1511
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1521..1614
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 1701 AA; 182867 MW; 00A282DD6BA49ED1 CRC64;
MDFLLQLLLL ALPIPADLTS WGVSSPETVK GMKGSCLIIP CTFSFPASVK VPDGITTIWY
YDYSGRRQVV SHSTNPQLVE ARFQGRAQLV GNPELKVCNL LLKDLQPEDS GSYNFRFEIS
EVNRWVDVKG TAVTVTEELI MPTVASPAEL HEGMEVDFNC STPYACLQEP VTLRWQGQDP
ARSITSTLQK LEPTGIHHQE TLHMALSWQD HGRTLSCQLS AANHRTQREI RLQVQYAPKG
VEILLSPSGR NILPGDLVTL ICQVNSSHPQ VSSVQWVKDG THLKTRSRVL QLPQAAWADA
GVYTCEAGNG VGSSVSPPVS LHIFMAVVQV SPAGSILENQ TVTLACNTPK EAPRELRYAW
YKNHGLMKDT HSRILQLHSV TRADTGFYFC EVQNAQGRER SDPVSVVVHH PPLTPHLTAF
LETQEGLVGI LQCSVVSEPL ASLVLSREGL ILASTSGEGD QSPRFSVYSA PNSLRLEIRD
LGPTDSGEYT CSATNSLGNS SSTLDFHANV ARLLISPAAE VAEGQAVTLS CRSSLSPMPD
THFSWYRNGA LLLEGPSSSL LLPVVSSTDA GSYHCRAQDG HGTSGLSSPA VLTVLYAPRR
PTFTAQLDPD TAGAGQRGLL LCRVDSDPPA QLRLLHRGRV VASALPSGGS CSACESCSSR
TKVTRAPNLL RVEIQDPVLE DEGVYLCEAS NVLGNASASA NFNAQATVLV ITPSHTLQEG
TGANLTCRVN REAGGPANFT WFRDGALWAQ GPLETLTLLP VARTDAALYA CRILTEAGAQ
LSTPVVLRVL YPPDPPKLSA LLDVDQGHTA VFVCTVDSRP PAQLALFHGE HLLATSPGPQ
LPSRGRLQAK TTANFLQLEV QDLSLKDSGS YRCEANNALG STNTSLFFQI RGAWVRVSPS
PELREGQAVV LSCQVPTGVL EGTSYRWYRD GQPLQEFTSA SVRFAAITLS QAGAYHCQAQ
APGSATTNLA APVSLHVSYA PRQATLTTLM DTGPGRLGLL LCHVNSDPPA QLRLLHGDRL
VASTLQGVGE LAGSSPRLQV AVAPNTLRLE IHNAVLEDEG IYTCEATNAL GQALASATFD
TQAVSVQVWP KATVQEGQLV NLTCLVWTTH VTQLTYTWYQ DGQQRPDAAH SCGVLIPGQT
LHLSRPVTLD VLYAPRSLRL TYLLESRGGQ LALVLCTVDS RPPAQLVLSH AGRLLASSTT
ASVPNTLQLE LWEPRPSDEG LYSCSARSPL GQVNTSLELR LEGVQVTLAP SATVPEGAPI
TVSCEDPAAR PPTVYAWYHN SRWLQEGPEA SLSFPVVTRA HAGAYSCQVR DAQGTRSSRP
TALHVLYAPR DAAVSSFWDS RTSPMAVVQC TVDSEPPAEL ALARNGKVLA TSNGIPGLAV
ETGHVQVARN ALRLRVQAVP SGDEDTYICT ARNLLGSVST TLGQLQAEGV HVLAEPGLDV
PEGAALNLSC QLPGGPGLMG NSTFTWFWNG RQLHTEPVPT LAFTHVARDH AGMYHCQAEL
PTGATASAPV TLRVLYPPKT PTMTVFVEPE GGIQGILDCR VDSEPLASLT LHLGSRLVAS
SQSKIAPAKP HIHVSVTPNA LRVVIEELRP SDQGEYVCSA SNSLGSASAA TYFGTRALHR
LQLFQQLLWV LGLLAGLLCL LLGLGAYYTW RRRHFQKLRE GENSVEMASH RETMQVSIHH
EEEVTRICDD SSPVNNAALG P
//
