ID W5NVT2_SHEEP Unreviewed; 308 AA.
AC W5NVT2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Natural cytotoxicity triggering receptor 1 {ECO:0000256|ARBA:ARBA00040484};
DE AltName: Full=Natural killer cell p46-related protein {ECO:0000256|ARBA:ARBA00041225};
GN Name=NCR1 {ECO:0000313|Ensembl:ENSOARP00000002278.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000002278.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000002278.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000002278.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000002278.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the natural cytotoxicity receptor (NCR) family.
CC {ECO:0000256|ARBA:ARBA00006531}.
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DR EMBL; AMGL01029830; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5NVT2; -.
DR SMR; W5NVT2; -.
DR STRING; 9940.ENSOARP00000002278; -.
DR PaxDb; 9940-ENSOARP00000002278; -.
DR Ensembl; ENSOART00000002329.1; ENSOARP00000002278.1; ENSOARG00000002157.1.
DR eggNOG; ENOG502RWVC; Eukaryota.
DR HOGENOM; CLU_021100_1_1_1; -.
DR OMA; VEFPIGP; -.
DR Proteomes; UP000002356; Chromosome 14.
DR Bgee; ENSOARG00000002157; Expressed in leukocyte and 31 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR PANTHER; PTHR11738; MHC CLASS I NK CELL RECEPTOR; 1.
DR PANTHER; PTHR11738:SF14; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 1; 1.
DR Pfam; PF13895; Ig_2; 1.
DR SMART; SM00409; IG; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..308
FT /note="Natural cytotoxicity triggering receptor 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004868290"
FT TRANSMEM 257..279
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 124..207
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 308 AA; 34530 MW; 342109EC9BD3860E CRC64;
MPSTLAVLLV LGLGLSQRSS TQKQMLSKPA IWVKPSFMIP KGRPATIGCR GAGGAMEYQL
HFEGGLSALE RPKSRPVMNW VKFPIPAMTS HTAGQYRCSY RSGELWSELS DPLDLVVTGL
YDTPTLSVEP RSEVTSGENV TFRCQLATAT STFFLLKAGQ SSRPQLRYGN LWAEFHLGPV
TPAHRGTYRC FGSYNNHAWS FPSKPVKLLV KGDAGDTTFA PTEHTASDYW DSYELTTGTQ
SQKDPDHFLW NHTVQNLIRL GLAVLVLVAL MGLLLEDWLH RRKSGKRAHW VSRRRCRRRL
RAQRALET
//
