ID W5NWL0_SHEEP Unreviewed; 2026 AA.
AC W5NWL0;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Calponin-homology (CH) domain-containing protein {ECO:0000259|PROSITE:PS50021};
GN Name=CCDC88A {ECO:0000313|Ensembl:ENSOARP00000002557.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000002557.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000002557.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000002557.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000002557.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AMGL01077390; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01077391; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01077392; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012026642.1; XM_012171252.2.
DR SMR; W5NWL0; -.
DR STRING; 9940.ENSOARP00000002557; -.
DR PaxDb; 9940-ENSOARP00000002557; -.
DR Ensembl; ENSOART00000002610.1; ENSOARP00000002557.1; ENSOARG00000002400.1.
DR eggNOG; KOG4643; Eukaryota.
DR HOGENOM; CLU_001421_1_0_1; -.
DR OMA; AVATHIQ; -.
DR Proteomes; UP000002356; Chromosome 3.
DR Bgee; ENSOARG00000002400; Expressed in embryo and 54 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030705; P:cytoskeleton-dependent intracellular transport; IEA:InterPro.
DR CDD; cd22229; HkD_Girdin; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR043936; HOOK_N.
DR PANTHER; PTHR18947:SF30; GIRDIN; 1.
DR PANTHER; PTHR18947; HOOK PROTEINS; 1.
DR Pfam; PF19047; HOOK_N; 1.
DR SUPFAM; SSF116907; Hook domain; 1.
DR PROSITE; PS50021; CH; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 12..132
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 816..842
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1007..1036
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1406..1458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1559..1601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1734..1847
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1970..1998
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 246..425
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1124..1151
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1180..1231
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1267..1382
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1415..1458
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1789..1818
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1978..1998
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2026 AA; 232803 MW; 85C322F49EA35ECF CRC64;
MENEVFTPLL EQFMTSPLVT WVKTFGPLAA GNGTNLDEYV ALVDGVFLNQ VMLQINPKSE
SQRVNKKVNN DASLRIHNLS ILVRQIKFYY QETLQQLIMM SLPNVLIIGK NPFSEQGTEE
VKKLLLLLLG CAVQCQKKEE FIERIQGLDF DTKAAVAAHI QEVTHNQENV FDLQWMEVTD
MSQEEIEPLL KNMVLHLKRL IDERDEHSET IVELSEERDG LHFLPHASSS AQSPCGSPGM
KRTESRQHLS VELADAKAKI RRLRQELEEK TEQLLDCKQE LEQMEIELKR LQQENMNLLS
DARSARMYRD ELDALREKAV RVDKLESEVS RYKERLHDIE FYKARVEELK EDNQVLLETK
TMLEDQLEGT RARSDKLHEL EKENLQLKAK LHDMEMERDM DRKKIEELME ENMTLEMAQK
QSMDESLHLG WELEQISRTS ELSEAPQKSL GHEVNELTSS RLLKLEMENQ SLTKTVEELR
STMDSAEGTT SKILKIEKEN QRLSKKVEIL ENEIIQEKQS LQNCQNLSKD LMKEKAQLEK
TIETLRENSE RQIKILEQEN EHLNQTVSSL RQRSQISAEA RVKDIEKENK ILHESIKETS
SKLSKIEFEK RQIRKELEHY KEKGERAEEL ENELHHLEKE NELLQKKITN LKITCEKIEA
LEQENSELER ENRKFKKTLD SFKNLTFQLE SLEKENSQLD EENLELRRSV ESLKCASMKM
AQLQLENKEL ESEKEQLKKG LELMKASFKK TERLEVSYQG LDTENQRLQK ALENSNKKIQ
QLESELQDLE MENQTLQKNL EELKISSKRL EQLEKENKSL EQETSQLEKD KKQLEKENKR
LRQQAEIKDT TLEENNVKIG NLEKENKTLF KEIGIYKESC VRLKELEKEN KELVKRATID
IKTLVTLRED LVSEKLKTQQ MNNDLEKLTH ELEKIGLNKE RLLHDEQSTD DRYKLLESKL
ESTLKKSLEI KEEKIAALEA RLEESTNYNQ QLRQELKTVK KNYEALKQRQ DEERMVQSSP
PAAGEDNKWE RESQETTREL LKVKDRLIEV ERNNATLQAE KQALKTQLKQ LETQNNNLQA
QILALQRQTV SLQEQNTTLQ TQNAKLQVEN STLNSQSTSL MNQNAQLLIQ QSSLENENES
VIKEREDLKS LYDSLVKDHE KLELLHERQA SEYETLIAKH GTLKSAHKNL EVEHKDLEDR
YNQLLKQKGQ LEDLEKTLKA EQEKMLLKNK NHETVAAEFK KLCGENDRLN HTYNQLLKET
EVLQTDHKNL KSLLNNSKLE QTRLEAEFSK LKEQYQQLDI TSTKLNNQCE LLSQLKGNLE
EENRHLLDQI QTLMLQNRTL LEQNMESKDL FHVEQRQYID KLNELRRQKE KLEEKIMDQY
KFYDPSPPRR RGNWITLKMR KLIKSKKDVN RERQKSLTLT PTRSDSSEGF LQLPHQDSQD
SSSVGSNSLE DGQTLGTKKS SMVALKRLPF LRNRPKDKDK MKACYRRSMS MNDLVQSMVL
AGGQWTGSTE NLEVPDDIST GKRRKELGAM AFSTTAINFS TVNSSTGFRS KQLVNNKDTT
SFEDVSPQGI SDDSSTGSRV HASRPASLDS GRTSTSNSNN NASLHEVKAG AVNIQSRPQS
HSSGEFSLLH EHEAWSSSGS SPIQYLKRQT RSSPVLQHRT LENRAHHKIK TGSPGSEVVT
LQQFLEESNK LTSMQLKPSS QENLLDEVMK SLSVSSDFLG KNKPVSCGLA RSVSGKTPGD
FHDRRTTKPE QFVRPGPQKA EDTCFTSSSG KPTRGAQGKI KLIKETSLSR QSKDSNPYAT
LPRASSVIST AEGTTRRTSI HDFLTKDSRL PMSVDSPPAT ADSSVTAPSS EYCLHQWSSH
TLQSPTSTLG SQAQNYLATD KPQSPHTQAR NSRTERSHLL NQTFAMVNTS NDAFGKSATD
SIESFTVAHP AQPFLSLNTE LVSNISGLPP RPVTRVTDQA SASLEKTAQK DNEQFSDHQS
HSSINPQSSV DSNNLTTPAC LYPDDTEAAL LVSEDTQTVW YEYGCV
//
