ID W5NYU9_SHEEP Unreviewed; 632 AA.
AC W5NYU9;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=55 kDa erythrocyte membrane protein {ECO:0000256|ARBA:ARBA00020455};
DE AltName: Full=Membrane protein, palmitoylated 1 {ECO:0000256|ARBA:ARBA00031599};
GN Name=MPP1 {ECO:0000313|Ensembl:ENSOARP00000003347.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000003347.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000003347.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000003347.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000003347.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Essential regulator of neutrophil polarity. Regulates
CC neutrophil polarization by regulating AKT1 phosphorylation through a
CC mechanism that is independent of PIK3CG activity.
CC {ECO:0000256|ARBA:ARBA00025177}.
CC -!- SUBCELLULAR LOCATION: Cell projection, stereocilium
CC {ECO:0000256|ARBA:ARBA00004645}.
CC -!- SIMILARITY: Belongs to the MAGUK family.
CC {ECO:0000256|ARBA:ARBA00007014}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMGL01116713; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01116714; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01116715; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5NYU9; -.
DR SMR; W5NYU9; -.
DR STRING; 9940.ENSOARP00000003347; -.
DR PaxDb; 9940-ENSOARP00000003347; -.
DR Ensembl; ENSOART00000003411.1; ENSOARP00000003347.1; ENSOARG00000003150.1.
DR eggNOG; KOG0609; Eukaryota.
DR HOGENOM; CLU_001715_5_1_1; -.
DR OMA; FESINSC; -.
DR Proteomes; UP000002356; Chromosome X.
DR Bgee; ENSOARG00000003150; Expressed in gastric lymph node and 55 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0032420; C:stereocilium; IEA:UniProtKB-SubCell.
DR CDD; cd00071; GMPK; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd12080; SH3_MPP1; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR035475; MPP1_SH3.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23122:SF37; 55 KDA ERYTHROCYTE MEMBRANE PROTEIN; 1.
DR PANTHER; PTHR23122; MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 43..68
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 237..318
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 324..394
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 448..617
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 83..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 632 AA; 69991 MW; 2F8E6CE85D3E8409 CRC64;
MAHSPELCKH RKCLFCSASF SCLRCWGERQ EGVRVLRNPA LAFVRNVGLL AATEPSIFCL
FVFVALILRD VLVRPFPAPR CAEPGPWGPR GRRPGGGRVQ RRRVGGATPP RARRSSCGGV
TAQARRVPAA FAASARRRLP GPRAPASARS RGPAAPASQA ARLSHKMTLK ASEGEGGGGM
RTALSDLYLE HLLQKHNRPE PVSPQLSAVM EDMYTNGPAA LGSPAQTQGQ EARKVRLIQF
EKVTEEPMGI TLKLNEKQSC TVARILHGGM VHRQGSLHVG DEILEINGTN VTNHSVDQLQ
KAMKETKGMI SLKVIPNQQN RLPALQMFMR AQFDYDPRKD NLIPCKEAGL KFITGDIIQI
INKDDSNWWQ GRVEGSSQES AGLIPSPELQ EWRVASGAHS APSEAPSCSP FGKKKKYKDK
YLAKHSAIFD QLDVVSYEEV VRLPAFKRKT LVLIGASGVG RSHIKSALLS QNPDKFAYPA
PYTTRPARKS EEDGKEYHFI STEEMTRSIS ANEFLEFGSY QGNMFGTKFE TVHQIHKQGK
VAILDIEPQT LKIVRTAELS PFIVFIAPTD QGIQTDALQQ LQKDSEAIRI HYAHYFDLSL
VNNSVEETLK TLQEAFDQAC RSPQWVPVSW VY
//
