ID W5NYX0_SHEEP Unreviewed; 1607 AA.
AC W5NYX0;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Rho GTPase-activating protein 21 {ECO:0008006|Google:ProtNLM};
GN Name=ARHGAP21 {ECO:0000313|Ensembl:ENSOARP00000003368.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000003368.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000003368.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000003368.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000003368.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction {ECO:0000256|ARBA:ARBA00004282}.
CC Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Cytoplasmic
CC vesicle membrane {ECO:0000256|ARBA:ARBA00004284}; Peripheral membrane
CC protein {ECO:0000256|ARBA:ARBA00004284}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004395}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004395}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMGL01024425; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01024426; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01024427; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01024428; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSOART00000003432.1; ENSOARP00000003368.1; ENSOARG00000003154.1.
DR HOGENOM; CLU_001776_0_0_1; -.
DR Proteomes; UP000002356; Chromosome 13.
DR Bgee; ENSOARG00000003154; Expressed in cerebellum and 54 other cell types or tissues.
DR ExpressionAtlas; W5NYX0; baseline.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-SubCell.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01253; PH_ARHGAP21-like; 1.
DR CDD; cd04395; RhoGAP_ARHGAP21; 1.
DR Gene3D; 1.20.5.220; -; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23175; PDZ DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR23175:SF16; RHO GTPASE-ACTIVATING PROTEIN 21; 1.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 56..165
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 925..1034
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1141..1333
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 302..322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 497..525
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 582..638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 665..696
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 781..812
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 851..879
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1081..1123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1349..1396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1412..1566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..225
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 304..322
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 588..638
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 851..869
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1089..1114
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1370..1394
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1421..1482
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1496..1510
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1529..1545
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1607 AA; 178697 MW; 9F3F3C9D88E377B1 CRC64;
MMATRRTGLP EGDVDTKLKA CGSPTCEVST SKDGKEQSET ISPSEDEMFS WPGPKTVMLK
RTSQGFGFTL RHFIVYPPES AIQFSFKDEE NGNRGGKQRN RLEPMDTIFV KQVKEGGPAF
EAGLCTGDRI IKVNGESVIG KTYSQVIALI QNSDTTLELS VMPKDEDILQ VAYSQDAYLK
GNEAYSGNAR NIPEPPPVCY PWPSSAPPAM AQPPEPPPPD STASKPQTSP PVLTQPGRAY
RMEIQVPPSP PEVAKSNTAV CVCNESVRTV IVPSEKVVDL LPNRSNHTVP AHRTEEVRYG
RNEQPSFKTA TRTTSPPSSV PTAHLIHQPG SRSLEPSGIL LKSGHYGGHS EGLVSRSPAV
ESPSVTVNHY SPNSHQHIDW KNYKTYKEYI DNRRLHMGCR TIQERLDSLR AASQSTADYN
QVVLNRAALQ VRRRSTSQDR VPQSIQVRQR SVSQERLEDS VLMMYCPRSA SQGALTSPSI
SFSNHRTRSW DYIEGQGETS ENVHSECPPP DANGERKQTY KWSGFTEQDD RRGIYERSRQ
QEIHKSFRGS NFTVAPSVVN SDSRRMSSRV GGSVSQFKKI PADLKPLQPS RNFQTTCGMS
QPRGISQDRS PLGKVRSNSL KAPSTHVPKP PSSQNSFVSI KDQRPVNHLH QNSLFNQQTW
LRTESAPDHQ VDTGKPPSLS GASVKPPALA SENASTPDFE LSVTQRNQDL NVQEVEIQQS
NAVDNKETVI LREKPPSGRQ TPQPLRHQSY ILAVSDQETG SDTTCWLPND ARREVHIKRM
EERKASSTTP PGDSLASIPF IDEPTSPSID HDISHIPASA VISASTSQVP SIATVPPSLT
TSAPLIRRQL SHDQESVGPP SLDAQPSSKT ERSKSYDEGL DDYREDAKLS FKHVSSLKGI
KILDSQKSSE DSGSRKDSSS EVFSDAAKEG WLHFRPLVTD KGKRVGGSIR PWKQMYVVLR
GHSLYLYKDK REQTTPSEEE QPISVNACLI DISYSETKRK NVFRLTTSDC ECLFQAEDRD
DMLAWIKTIQ ESSNLNEEDT GVTNRDLISR RIKEYNSLMS KAEPLPKTPR QSLSIRQTLL
GAKAEPRTQS PHSPKEESER KLLSKDDTSP PKDKGTWRKG IPSIMRKTFE KKPTATGTFG
VRLDDCPPAH TNRYIPLIVD ICCKLVEERG LEYTGIYRVP GNNAAISSMQ EELNKGMADI
DIQDDKWRDL NVISSLLKSF FRKLPEPLFT NDKYADFIEA NRKEDPLDRL KTLKRLIHDL
PEHHYETLKF LSAHLKTVAE NSEKNKMEPR NLAIVFGPTL VRTSEDNMTH MVTHMPDQYK
IVETLIQHHD WFFTEEGAEE PLTTVQEENT VDSQPVPNID HLLTNIGRTG VSPGDVSDSA
TSDSTKSKGS WGSGKDQYSR DLLVSSIFAA ASRKRKKPKE KAQPSSSEDE LDNVFFKKEN
SEQGHHDIKE ESKKESETQG RKQRTVAPKE NNTKKDSSGG GRAEQRAPRG ESLEPPAPQS
TKQSRSPTLS CRLAVLRESP RALAAQKTSH LEDTGSDSGT PLSTRAPAPL ASFPTRKPPS
PEPKHSELLV SVGSITSDYA GAPSAPYLAC IVYHRHCPFK VEPGRRS
//
