ID W5NZ49_SHEEP Unreviewed; 690 AA.
AC W5NZ49;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=DHX33 {ECO:0000313|Ensembl:ENSOARP00000003447.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000003447.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000003447.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000003447.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000003447.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR EMBL; AMGL01017977; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5NZ49; -.
DR SMR; W5NZ49; -.
DR STRING; 9940.ENSOARP00000003447; -.
DR PaxDb; 9940-ENSOARP00000003447; -.
DR Ensembl; ENSOART00000003511.1; ENSOARP00000003447.1; ENSOARG00000003235.1.
DR eggNOG; KOG0922; Eukaryota.
DR HOGENOM; CLU_001832_5_11_1; -.
DR OMA; KVKVWRH; -.
DR Proteomes; UP000002356; Chromosome 11.
DR Bgee; ENSOARG00000003235; Expressed in adrenal cortex and 53 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd17978; DEXHc_DHX33; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF118; ATP-DEPENDENT RNA HELICASE DHX33; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 65..233
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 258..431
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..47
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 690 AA; 77196 MW; C3B43AD409D4FABD CRC64;
PDSRRSVPPP PLAPRRLLLA AGGGGGGGGR RQQPSLAQPS ASPYPEAVEQ QRRNLPIFQA
RGQLLAQLRN LDSAVLIGET GSGKTTQIPQ YLYEGGIGRQ AIIAVTQPRR VAAISLATRV
SDEKRTELGK LVGYTVRFDD VTSDDTKIKF LTDGMLLREA ILDSLLRKYS CIILDEAHER
TVHTDVLFGV VKAAQKRRKE LGKLPLKVIV MSATMDVDLF SQYFNGAPVL YLEGRQHPIQ
IFYTKQPQHD YLHAALVSVF QIHQEAPSSH DILVFLTGQE EIEAMSKTCR DIAKHLPDGC
PSMLVLPLYA SLPYAQQLRV FQGAPKGYRK VIISTNIAET SITITGIKYV VDTGMVKAKK
YNPDSGLEVL AVQRVSKTQA WQRTGRAGRE DSGICYRLYT EDEFEKFEKM TVPEIQRCNL
ASVMLQLLAM KVPNVLTFDF MSKPSPDHIQ AAIAQLELLG ALEHRDGQLT LTPMGRKMAA
FPLEPKFAKT ILLSPKFHCT EEILTIVALL SVDSILYNPP SRRDEVQSVR KKFVSSEGDH
LTLLNVYRTF KNTGGNKEWC KENFVNSKNM MLVAEVRAQL RDICIKNQMS MPILSSRGDT
ENIRRCLAHS LFMSTAELQP DGSYATTDTH QPVAIHPSSV LFHCKPACVV YTELLFTNKC
YMRDLCVVDA EWLYEAAPDF FRKKLRNARN
//
