ID W5P0F7_SHEEP Unreviewed; 551 AA.
AC W5P0F7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=E3 ubiquitin-protein ligase {ECO:0000256|RuleBase:RU369081};
DE EC=2.3.2.27 {ECO:0000256|RuleBase:RU369081};
DE AltName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|RuleBase:RU369081};
GN Name=MGRN1 {ECO:0000313|Ensembl:ENSOARP00000003905.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000003905.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000003905.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000003905.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000003905.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: E3 ubiquitin ligase. {ECO:0000256|RuleBase:RU369081}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900,
CC ECO:0000256|RuleBase:RU369081};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU369081}.
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DR EMBL; AMGL01068159; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01068160; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01068161; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01068162; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5P0F7; -.
DR STRING; 9940.ENSOARP00000003905; -.
DR PaxDb; 9940-ENSOARP00000003905; -.
DR Ensembl; ENSOART00000003974.1; ENSOARP00000003905.1; ENSOARG00000003653.1.
DR eggNOG; KOG4265; Eukaryota.
DR HOGENOM; CLU_016631_1_1_1; -.
DR Proteomes; UP000002356; Chromosome 24.
DR Bgee; ENSOARG00000003653; Expressed in pituitary gland and 51 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR045194; MGRN1/RNF157-like.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR22996:SF2; E3 UBIQUITIN-PROTEIN LIGASE MGRN1; 1.
DR PANTHER; PTHR22996; MAHOGUNIN; 1.
DR Pfam; PF13920; zf-C3HC4_3; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|RuleBase:RU369081};
KW Metal-binding {ECO:0000256|RuleBase:RU369081};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Transferase {ECO:0000256|RuleBase:RU369081};
KW Ubl conjugation pathway {ECO:0000256|RuleBase:RU369081};
KW Zinc {ECO:0000256|RuleBase:RU369081};
KW Zinc-finger {ECO:0000256|RuleBase:RU369081}.
FT REGION 345..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 433..551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 482..509
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 551 AA; 59882 MW; 8A8D549D867A4EC9 CRC64;
MFLVGRAGPR RLQPRLLSSP GNYFASHFFM GGEKFDTPHP EGYLFGENMD LNFLGNRPVQ
FPYVTPAPHE PVKTLRSLVN IRKDSLRLVR YKDGTDSPTE DGEKPRVLYS LEFTFDADAR
VAITVYCQAV EEFLNGTAAY SPKSPALQSE TVHYKRGVSQ QFSLPSFKID FSEWKDDELN
FDLDRGVFPV VIQAVVDEGD VVEVTGHAHV LLAAFEKHMD GSFSVKPLKQ KQIVDRVSYL
LQEIYGIENK NNQETKPSDE ENSDNSSECV VCLSDLRDTL ILPCRHLCLC NSCADTLRYQ
SSDSFLYSIP TFRALLQIRA VRKKPGALSP ISFSPVLAQS MDHDEHSCPF KKSKSHPASL
ASKKPKGETT HYPQSRRARP GSSPCHLLQT LTGFLAETPT APAPSVCHRT APKTGEATGL
SFGRGSLPLC AGPGGLLPRT PQPGAPVLAP RLTLRSPSSP IHEEDDSEAL PAPGGAGLAL
SSSPESFMTE TVDETSSLKQ GSRVPSIENV LQDGSPEPCG RSQPSAPADS APADVYLPAL
GPGSCSAGLE E
//
