ID W5PCP8_SHEEP Unreviewed; 369 AA.
AC W5PCP8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Biglycan {ECO:0000256|ARBA:ARBA00017012, ECO:0000256|RuleBase:RU364096};
GN Name=BGN {ECO:0000313|Ensembl:ENSOARP00000008210.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000008210.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000008210.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000008210.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000008210.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May be involved in collagen fiber assembly.
CC {ECO:0000256|ARBA:ARBA00002214, ECO:0000256|RuleBase:RU364096}.
CC -!- SUBUNIT: Homodimer. Forms a ternary complex with MFAP2 and ELN.
CC {ECO:0000256|ARBA:ARBA00025976}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|PIRNR:PIRNR002490,
CC ECO:0000256|RuleBase:RU364096}.
CC -!- SIMILARITY: Belongs to the small leucine-rich proteoglycan (SLRP)
CC family. SLRP class I subfamily. {ECO:0000256|ARBA:ARBA00009811,
CC ECO:0000256|PIRNR:PIRNR002490, ECO:0000256|RuleBase:RU364096}.
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DR EMBL; AMGL01116869; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01116870; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5PCP8; -.
DR SMR; W5PCP8; -.
DR Ensembl; ENSOART00000008332.1; ENSOARP00000008210.1; ENSOARG00000007656.1.
DR HOGENOM; CLU_000288_186_0_1; -.
DR OMA; GHNNIRM; -.
DR OrthoDB; 3953748at2759; -.
DR Proteomes; UP000002356; Chromosome X.
DR Bgee; ENSOARG00000007656; Expressed in aortic valve and 51 other cell types or tissues.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0031012; C:extracellular matrix; IEA:Ensembl.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0042383; C:sarcolemma; IEA:Ensembl.
DR GO; GO:0030133; C:transport vesicle; IEA:Ensembl.
DR GO; GO:0019955; F:cytokine binding; IEA:Ensembl.
DR GO; GO:0050840; F:extracellular matrix binding; IEA:Ensembl.
DR GO; GO:0005539; F:glycosaminoglycan binding; IEA:Ensembl.
DR GO; GO:0061975; P:articular cartilage development; IEA:Ensembl.
DR GO; GO:0060348; P:bone development; IEA:Ensembl.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR InterPro; IPR016352; SLRP_I_decor/aspor/byglycan.
DR PANTHER; PTHR45712; AGAP008170-PA; 1.
DR PANTHER; PTHR45712:SF11; BIGLYCAN; 1.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF01462; LRRNT; 1.
DR PIRSF; PIRSF002490; SLRP_I; 1.
DR SMART; SM00364; LRR_BAC; 3.
DR SMART; SM00369; LRR_TYP; 8.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR002490-1};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530,
KW ECO:0000256|PIRNR:PIRNR002490};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|PIRNR:PIRNR002490, ECO:0000256|RuleBase:RU364096}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|PIRNR:PIRNR002490,
FT ECO:0000256|RuleBase:RU364096"
FT CHAIN 17..369
FT /note="Biglycan"
FT /evidence="ECO:0000256|PIRNR:PIRNR002490,
FT ECO:0000256|RuleBase:RU364096"
FT /id="PRO_5011022800"
FT DOMAIN 63..95
FT /note="LRRNT"
FT /evidence="ECO:0000259|SMART:SM00013"
FT DISULFID 64..70
FT /evidence="ECO:0000256|PIRSR:PIRSR002490-1"
FT DISULFID 68..77
FT /evidence="ECO:0000256|PIRSR:PIRSR002490-1"
FT DISULFID 322..355
FT /evidence="ECO:0000256|PIRSR:PIRSR002490-1"
SQ SEQUENCE 369 AA; 41590 MW; B86C2149723AD0DA CRC64;
MWPLWPLAAL LALSQALPFE QKAFWDFTLD DGLPMLNDEE ASGAETTSGI PDLDSLPPTY
SAMCPFGCHC HLRVVQCSDL GLKAVPKEIS PDTTLLDLQN NDISELRKDD FKGLQHLYAL
VLVNNKISKI HEKAFSPLRK LQKLYISKNH LVEIPPNLPS SLVELRIHDN RIRKVPKGVF
SGLRNMNCIE MGGNPLENSG FEPGAFDGLK LNYLRISEAK LTGIPKDLPE TLNELHLDHN
KIQAIELEDL LRYSKLYRLG LGHNQIRMIE NGSLSFLPTL RELHLDNNKL SRVPAGLPDL
KLLQVVYLHT NNITKVGVND FCPVGFGVKR AYYNGISLFN NPVPYWEVQP ATFRCVTDRL
AIQFGNYKK
//
