ID W5PH85_SHEEP Unreviewed; 1161 AA.
AC W5PH85;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=VWFA domain-containing protein {ECO:0000259|PROSITE:PS50234};
GN Name=ITGAX {ECO:0000313|Ensembl:ENSOARP00000009802.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000009802.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000009802.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000009802.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000009802.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR EMBL; AMGL01069102; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01069103; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5PH85; -.
DR SMR; W5PH85; -.
DR STRING; 9940.ENSOARP00000009802; -.
DR PaxDb; 9940-ENSOARP00000009802; -.
DR Ensembl; ENSOART00000009944.1; ENSOARP00000009802.1; ENSOARG00000009130.1.
DR eggNOG; KOG3637; Eukaryota.
DR HOGENOM; CLU_004111_3_0_1; -.
DR OMA; KGEAVWT; -.
DR Proteomes; UP000002356; Chromosome 24.
DR Bgee; ENSOARG00000009130; Expressed in leukocyte and 50 other cell types or tissues.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 2.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR048633; ITGAX-like_Ig_3.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF118; INTEGRIN ALPHA-X; 1.
DR Pfam; PF01839; FG-GAP; 3.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF00357; Integrin_alpha; 1.
DR Pfam; PF21520; ITGAX-like_Ig_3; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 4.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51470; FG_GAP; 5.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 18..1161
FT /note="VWFA domain-containing protein"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5001426622"
FT TRANSMEM 1106..1128
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 23..77
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 188..328
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REPEAT 339..390
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 442..502
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 505..563
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 568..628
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ SEQUENCE 1161 AA; 127749 MW; 18FE262D6B947432 CRC64;
MTVTQVFLFL LMAPVSSLCF NLDMEQPTTF RVDSPGFGHS VVQYAQWLVV GAPQEVKAAN
QTGGLYWCDY SMGRCEAIPL KVPPEAVNMS LGLSMAATTD PFQLLACGPT VHHACRENMH
LTGICFLLAS PFQQVKRIPA ALQVCPVSAQ ELSLVVAGGG GLKIYRSQSW APLAHLTLYT
AWRPSPAFSL VQFSDRFQEH FTFKDFATSS DPLNLLNSVW QLGGWTFTAS AIRFVTDRLL
SAAYGARKDA SKILIVITDG EKTEKVDYKE VIPRAEAAGI IRYAIGVGSA FRYRNSLQEL
IDIASTPSKE HVFQVENFDA LRDIQKQLKE KIFAIEGTQT ISSSSFELEM SQEGFSGVFM
PDGPVLGAVG SFSWSGGAFL YPQNKNPTFI NMSQEHVDMR DSYLGETRLW LGAGQEMGCL
GRRGARGWGM SVFSYPASSG STLKQGLTMK QIGSYFGASL CSVDVNRDGS PDLVLIGAPH
FYEQMRGGQV SVCPFPRGRA KWKCDAVLQG ELGHPWGRFG AALTALGDVN GDRLADVAVG
APGEQENRGA VYLFHGTSEL GISPSHSQRV TGAQLSPSLQ YFGQSLSGGQ DLTQDGLADL
AVGAQGHALL LRTRPVLRMW ANIHITPAEI ARSVYECEPL ATFPHDLGKA TVCLHVSQSP
KNQLVNLQSI VTFDLTLDPG RLSPRAIFQE TRTRNLTRVQ ELGLKQHCEA VRLLLPDCVE
DSVTPIILRL NFSLVGKPIS SLRNLQPMLA VDAQRYFTTS LPFEKNCGAD HVCQDDLSIS
FGVSDLKTLM VGSNLELNLK VRVWNDGEDS YGTAVTFFYP PGLSYRRVTG GQNHRATRSQ
RVTFPLPCDS APAGTQGTRS TRCSVSHFIF REGAQITFTV TFHVSPTATL GDKLLLVANV
SSENNSPKTS KTTFQLELPV KYAVYTVISS HEQSTKYLNF SASQEEGSRE AQHRYQVNNL
GQRELPVSID ISVPMELNQV AVWKDIEVLS PQNPSIQCSS ERTAPTESDF LTHFKKKPVL
DCSIADCLRF RCDIPSFGIQ EELDFILKGN LSFRWVSQTQ QKKVLVVSVA EITFNRLVYS
QLPGQEIFLR AQTELVLEKY EIYNPIPLIV GSSVGGLLLL ALITALLYKV GFFKRQYREM
MEGANKQTVP ENETGDPQVA Q
//
