ID W5PJL1_SHEEP Unreviewed; 879 AA.
AC W5PJL1;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Prominin-1 {ECO:0008006|Google:ProtNLM};
GN Name=PROM1 {ECO:0000313|Ensembl:ENSOARP00000010632.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000010632.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000010632.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000010632.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000010632.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, microvillus membrane
CC {ECO:0000256|ARBA:ARBA00004475}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004475}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the prominin family.
CC {ECO:0000256|ARBA:ARBA00006058}.
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DR EMBL; AMGL01100377; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01100378; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01100379; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01100380; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01100381; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01100382; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01100383; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5PJL1; -.
DR STRING; 9940.ENSOARP00000010632; -.
DR PaxDb; 9940-ENSOARP00000010632; -.
DR Ensembl; ENSOART00000010789.1; ENSOARP00000010632.1; ENSOARG00000009911.1.
DR eggNOG; KOG4331; Eukaryota.
DR OMA; VYHLMMY; -.
DR Proteomes; UP000002356; Chromosome 6.
DR Bgee; ENSOARG00000009911; Expressed in fallopian tube and 50 other cell types or tissues.
DR ExpressionAtlas; W5PJL1; baseline and differential.
DR GO; GO:0031528; C:microvillus membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR008795; Prominin.
DR PANTHER; PTHR22730; PROMININ PROM PROTEIN; 1.
DR PANTHER; PTHR22730:SF3; PROMININ-1; 1.
DR Pfam; PF05478; Prominin; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..879
FT /note="Prominin-1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004869207"
FT TRANSMEM 103..136
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 157..178
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 433..459
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 480..506
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 794..814
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 879 AA; 99429 MW; 580EAB2D0C392935 CRC64;
MALLLGFLLL LGLCEDTMSE EPSSSQYRPG GLEFQLPPTS YQTSDSYDPG PAGLFFHIVR
LFVHIVQPNA FPEDILRKTI QKKFDPSKEY DKPENVVLTL KIIYYEIGII ICAALGLLFV
VLMPLVGFFF CLCRCCNKCG GEMHQRQKRS GPFLKKCYTI SLLVICVFIS IGIIYGFAAN
QYMRTRVEET RKLSDSNFND LRTLLNVVPG QIDYILDQFT HPKEKAFDDL DNINSLVGDG
IYEHLKPKVL PVLKDIKDLA KDMKANRDTL VQANTVLTDV KHSSAFLRTS LRDVKTSMEQ
TLTDPQCSFP AVAPTCNSIR KSLSVLDDSA NFDHLPSLDG HITQLDGLLQ TDLSSLVQKA
NESLSNIPEE VQNQTRDFIT EFKKTLNSIQ SDVKNISTKI PIQKTLSSFV RYINNSEDYI
LHYLPTIEEC DSYRWLVCLV VCCLLTLILT FYLLGLLCGT LGYDQNATPT RRGCVSNTGG
LLLMVGAGFS FFFSWIVMTI VVLTFVAGGN MEKLVCEPYR NKKLFQVLDT PYLLNEDWKY
YLSGLVLNKP DVNLTFEQVY SDCKENKGLY ATLKLDHIYN VSEQLNITKH TGDINSNLEN
MNIRIEDIEL LDKTGMKTLM DLRSSGIDDI DYAAYLNATE RSPTRVNLIS FANDIQRKAN
QLPSGRLKTS LKSHADTLIN IHQNQVIPLQ NSMSTTNKQM KTLHYRTSGL KVRVSTTIFF
LNSTQDFLTS QLSKIVVEES KQFGSKIISY FEWYLQWVEM TITQQFAACK PAATAVDSAV
NVFLCSYIVD PLNLFWFGMG KATMLLLPAV IFAVKLAKYF RRMYSEDVYE DDPVNKVQSK
PRVQTVPGVQ TVPMVQTVPM KNMRHANSRA RAEQGTRTI
//
