ID W5PLS9_SHEEP Unreviewed; 476 AA.
AC W5PLS9;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Centrosomal protein 57kDa-like protein 1 {ECO:0000256|ARBA:ARBA00041218};
DE AltName: Full=Cep57-related protein {ECO:0000256|ARBA:ARBA00042578};
GN Name=CEP57L1 {ECO:0000313|Ensembl:ENSOARP00000011402.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000011402.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000011402.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000011402.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000011402.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
CC -!- SIMILARITY: Belongs to the translokin family.
CC {ECO:0000256|ARBA:ARBA00008179}.
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DR EMBL; AMGL01106490; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01106491; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01106492; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01106493; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01106494; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01106495; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01106496; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01106497; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012038040.1; XM_012182650.1.
DR AlphaFoldDB; W5PLS9; -.
DR SMR; W5PLS9; -.
DR PaxDb; 9940-ENSOARP00000011402; -.
DR Ensembl; ENSOART00000011562.1; ENSOARP00000011402.1; ENSOARG00000010624.1.
DR eggNOG; ENOG502QTVF; Eukaryota.
DR HOGENOM; CLU_034321_0_0_1; -.
DR OMA; LQTMQHY; -.
DR OrthoDB; 5324077at2759; -.
DR Proteomes; UP000002356; Chromosome 8.
DR Bgee; ENSOARG00000010624; Expressed in gastric lymph node and 55 other cell types or tissues.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0043015; F:gamma-tubulin binding; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR Gene3D; 1.20.58.90; -; 1.
DR InterPro; IPR025913; Cep57_CLD.
DR InterPro; IPR024957; Cep57_MT-bd_dom.
DR PANTHER; PTHR19336:SF10; CENTROSOMAL PROTEIN CEP57L1; 1.
DR PANTHER; PTHR19336; UNCHARACTERIZED DUF1167; 1.
DR Pfam; PF14073; Cep57_CLD; 1.
DR Pfam; PF06657; Cep57_MT_bd; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 55..232
FT /note="Cep57 centrosome localisation"
FT /evidence="ECO:0000259|Pfam:PF14073"
FT DOMAIN 329..401
FT /note="Cep57 centrosome microtubule-binding"
FT /evidence="ECO:0000259|Pfam:PF06657"
FT REGION 238..257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 412..431
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 53..108
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 190..217
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 337..394
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 476 AA; 54950 MW; 0EC4ECDCAE4582C2 CRC64;
MDSELMHSIV GSYLKPPERV CVPSVTQSDE SSQTHYSVNL EVTSSKMLHS PNSQALILAL
KTLQEKIHRL ELERTQAEDN LNILSREAAQ YKKALENETS ERNLAHEELI KQKKDISMQL
SSAQSRCILL EKQLEYTKRM VLNVEREKNM ILEQQAQLQR EKEQDHMKLH AKLEKLDVLE
KECFKLTTTQ KTAEDKIKHL EEKLKEEEHQ RKLFQDKASQ LQTGLEISRI LMSSVTNPRH
FKEKKKSSKK TKCLKRGPPQ QICSKFGTLP IIAEKSASAS HSANASTQNL QTVQHSGPRI
LQKPAEVTEL RCLYKTSRTT SQCKAVPSDS EKSISIYNNL SELLMAMQDE LDQMTMEYQD
LLNQMKETES QSVCEDIECE LERLVKKMEI KGEQISKLMQ HQDSVRRLQQ KVQNSKMSKT
SAIQQEDSNC KGTKNIKNSS RKCLLTNSLQ KNSNCRPIRV HNLQMKLRRD DIMWEQ
//
