ID   W5PPB6_SHEEP            Unreviewed;       690 AA.
AC   W5PPB6;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   RecName: Full=SEL1L2 adaptor subunit of ERAD E3 ligase {ECO:0008006|Google:ProtNLM};
GN   Name=SEL1L2 {ECO:0000313|Ensembl:ENSOARP00000012292.1};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000012292.1, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000012292.1, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000012292.1,
RC   ECO:0000313|Proteomes:UP000002356};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA   Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000012292.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the sel-1 family.
CC       {ECO:0000256|ARBA:ARBA00038101}.
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DR   EMBL; AMGL01023739; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01023740; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01023741; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; W5PPB6; -.
DR   SMR; W5PPB6; -.
DR   STRING; 9940.ENSOARP00000012292; -.
DR   PaxDb; 9940-ENSOARP00000012292; -.
DR   Ensembl; ENSOART00000012468.1; ENSOARP00000012292.1; ENSOARG00000011461.1.
DR   eggNOG; KOG1550; Eukaryota.
DR   HOGENOM; CLU_007931_2_1_1; -.
DR   OMA; IAANKYH; -.
DR   Proteomes; UP000002356; Chromosome 13.
DR   Bgee; ENSOARG00000011461; Expressed in testis and 1 other cell type or tissue.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR   InterPro; IPR006597; Sel1-like.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR11102:SF53; PROTEIN SEL-1 HOMOLOG 2; 1.
DR   PANTHER; PTHR11102; SEL-1-LIKE PROTEIN; 1.
DR   Pfam; PF08238; Sel1; 11.
DR   SMART; SM00671; SEL1; 11.
DR   SUPFAM; SSF81901; HCP-like; 3.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        669..685
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   690 AA;  78179 MW;  07F2B253BA6E6E8D CRC64;
     LTPLFVELFQ VISVSGYLIK KSIEAEKHSK KQKGRNVTTQ ASVNNVKRYL SNVLEQRKPI
     NVISKKENLL ENKKNHHKLR RKGIQNKDLW KRNKDHLENQ AKNNFTDEGD QLFKMGIKIL
     QQSKSQKQKA EAYIFFAKAA DLGNLKAMEK MADALLFGNF GMQNITAAIQ LYESLAKEGS
     YKAQNALGFL SSYGIGMEYN QAKALIYYTF GSAGGSMMSQ MILGYRYLSG INVLQNCEVA
     LSHYKKVADY IADKLEKSEG IPVEKVRLTE RPENLSSNSE ILDWDIYQYY KFLAERGDVQ
     IQVSLGQLHL IGRKGLDQDY YKALYYFLKA AKAGSANAMA FIGKMYLEGN AAAPQNNATA
     FKYFSMAASK GNAIGLHGLG LLYFYGKGVP VNYAEALKYF QKAAEKGWPN AQFQLGFMYY
     SGSGVWKDYK LAFKYFYLAS QSGQPLAVYY LAEMYATGTG VLRSCRTAVE LYKGVCELGH
     WAEKFLTAYF AYKNGDIDSS LVQYALLAEM GYEVAQSNSA FILESKKAKI LEKEKMYPMA
     LLLWNRAAIQ GNAFARVKIG DYHYYGYGTK RDYQTAATHY SIAADKYHSA QAMFNLGYMY
     EHGLGITKDI HLARRLYDMA AQTSPDAHIP VFLALMKLET VHLLQDILFF NFTMRWKWTV
     LDNTIGPCWD LFVIGLIVAV LIFLLRNRYG
//