ID W5PQ35_SHEEP Unreviewed; 852 AA.
AC W5PQ35;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=VWFA domain-containing protein {ECO:0000259|PROSITE:PS50234};
GN Name=INTS6L {ECO:0000313|Ensembl:ENSOARP00000012562.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000012562.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000012562.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000012562.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000012562.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AMGL01117748; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01117749; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01117750; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_014960499.1; XM_015105013.1.
DR AlphaFoldDB; W5PQ35; -.
DR Ensembl; ENSOART00000012747.1; ENSOARP00000012562.1; ENSOARG00000011718.1.
DR GeneID; 101105554; -.
DR CTD; 203522; -.
DR HOGENOM; CLU_006789_0_0_1; -.
DR OrthoDB; 50779at2759; -.
DR Proteomes; UP000002356; Chromosome X.
DR Bgee; ENSOARG00000011718; Expressed in pituitary gland and 54 other cell types or tissues.
DR ExpressionAtlas; W5PQ35; baseline and differential.
DR CDD; cd00198; vWFA; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR029307; INT_SG_DDX_CT_C.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR12957; DEAD/H BOX POLYPEPTIDE 26/DICE1-RELATED; 1.
DR PANTHER; PTHR12957:SF22; INTEGRATOR COMPLEX SUBUNIT 6-LIKE; 1.
DR Pfam; PF15300; INT_SG_DDX_CT_C; 1.
DR Pfam; PF13519; VWA_2; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 3..227
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 644..684
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 662..678
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 852 AA; 95737 MW; EC1CC5DDC4D0FA77 CRC64;
MPILLFLIDT SASMNQRTDL GTSYLDIAKG AVELFLKLRA RDPASRGDRY ILVTYDEPPY
CIKAGWKENH ATFMSELKNL QASGLTTLGQ ALRSSFDLLN LNRLISGIDN YGQGRNPFFL
EPSILITITD GNKLTSTSGV QEELHLPLNS PLPGSELTKE PFRWDQRLFA LVLRLPGLAS
TEPEQIGSVP TDESAITQMC EVTGGRSYCV RTQRMLNQCL ESLVQKVQSG VVINFEKTGP
DPLPIGEDGL MDSSRPSNSF AAQPWHSCHK LIYVRPNSKT GVPVGHWPIP ESFWPDQNLP
SLPPRTSHPI VRFSCIDCEP MVIDKLPFDK YELEPSPLTQ YILERKSPHT CWQVFVTSSG
KYNELGYPFG YLKASTTLTC VNLFVMPYNY PVLLPLLDDL FKVHKLKPNL KWRQAFDSYL
KTLPPYYLLP LKKALRMMGA PNLISDNLDC GLSYSVISYL KKLSQQTKLE SERILASVGK
KPPQEIGIKV KNHSGGGVSL THNKNFRKLL KEIIGDTAPR LTELNTKEFA GFQVGLLNKD
LKPQTYRNAY DIPRRDLLDQ LTRMRSNLLK THKFIVGQDE DTLHSVPVAQ MGNYQEYLKT
LASPLREIDP DQPKRLHTFG NPFKQDKKGM MIDEADEFVA GPQNKVKRPG EVNSALSSKR
RRSVTVTHDA HEEKMENGQI SPDGFLSKSA SPELMNMAGD GIPPDQVDSL SDDFTSLRED
GPIHKPGSNA LIGETKNCSV SVDDQKVSVT SALEIVPSTL QITPAMAQGI NADIKHQLMK
EVRKFGRKYE RIFTLLEGVQ GPLAVKKQFV EFTIKEAARF KRRVLIQYLE KVLEKIESYH
LLNNVNHINS RS
//
