ID W5PQZ6_SHEEP Unreviewed; 998 AA.
AC W5PQZ6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Ubiquitin-activating enzyme E1 C-terminal domain-containing protein {ECO:0000259|SMART:SM00985};
GN Name=CDHR4 {ECO:0000313|Ensembl:ENSOARP00000012874.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000012874.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000012874.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000012874.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000012874.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the ubiquitin-activating E1 family.
CC {ECO:0000256|ARBA:ARBA00005673}.
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DR EMBL; AMGL01045637; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01045638; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01045639; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01045640; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5PQZ6; -.
DR SMR; W5PQZ6; -.
DR STRING; 9940.ENSOARP00000012874; -.
DR PaxDb; 9940-ENSOARP00000012874; -.
DR Ensembl; ENSOART00000013061.1; ENSOARP00000012874.1; ENSOARG00000011997.1.
DR eggNOG; KOG2012; Eukaryota.
DR HOGENOM; CLU_002556_0_0_1; -.
DR OMA; FWSGHRK; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000002356; Chromosome 19.
DR Bgee; ENSOARG00000011997; Expressed in fallopian tube and 53 other cell types or tissues.
DR ExpressionAtlas; W5PQZ6; baseline.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008641; F:ubiquitin-like modifier activating enzyme activity; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd01491; Ube1_repeat1; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 2.40.30.180; Ubiquitin-activating enzyme E1, FCCH domain; 1.
DR Gene3D; 3.50.50.80; Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1; 1.
DR Gene3D; 3.40.50.12550; Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2; 1.
DR Gene3D; 1.10.10.2660; Ubiquitin-activating enzyme E1, SCCH domain; 1.
DR Gene3D; 3.10.290.60; Ubiquitin-activating enzyme E1, UFD domain; 1.
DR InterPro; IPR032420; E1_4HB.
DR InterPro; IPR032418; E1_FCCH.
DR InterPro; IPR042302; E1_FCCH_sf.
DR InterPro; IPR045886; ThiF/MoeB/HesA.
DR InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR InterPro; IPR018965; Ub-activating_enz_E1_C.
DR InterPro; IPR042449; Ub-E1_IAD_1.
DR InterPro; IPR038252; UBA_E1_C_sf.
DR InterPro; IPR019572; UBA_E1_SCCH.
DR InterPro; IPR042063; Ubi_acti_E1_SCCH.
DR InterPro; IPR035985; Ubiquitin-activating_enz.
DR InterPro; IPR018075; UBQ-activ_enz_E1.
DR InterPro; IPR000011; UBQ/SUMO-activ_enz_E1-like.
DR NCBIfam; TIGR01408; Ube1; 1.
DR PANTHER; PTHR10953; UBIQUITIN-ACTIVATING ENZYME E1; 1.
DR PANTHER; PTHR10953:SF143; UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 7; 1.
DR Pfam; PF16191; E1_4HB; 1.
DR Pfam; PF16190; E1_FCCH; 1.
DR Pfam; PF09358; E1_UFD; 1.
DR Pfam; PF00899; ThiF; 2.
DR Pfam; PF10585; UBA_E1_SCCH; 1.
DR PRINTS; PR01849; UBIQUITINACT.
DR SMART; SM00985; UBA_e1_C; 1.
DR SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 2.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 873..994
FT /note="Ubiquitin-activating enzyme E1 C-terminal"
FT /evidence="ECO:0000259|SMART:SM00985"
SQ SEQUENCE 998 AA; 110204 MW; 26C35F801F405480 CRC64;
MDTLETSKSL DKELYSRQLY VLGLPAMRRI QGAKVLLSGL QGLGAEVAKN LVLMGVGSLT
LHDPHPTCWS DLAAQFLLSE QDLGRSRAEA SQKLLAELNG AVQVSVYTGD ITEDLLLDFQ
VVVLTASRLE EQLRVGTLCH EHGVCFLVAD TRGLVGQLFC DFGKNFTVQD PTEAEPLMAT
IQHISQGSPG ILTLREEADA HHFHTGDWVT FSGIEGMVEL NGCDPRPLHV REDGTLEIGD
TTAFSRYLRG GAVTEVKRAK TVSHEPLDTA LLQPRVVAQS PQEVHRARCL HQSFRSLHKF
QQLHGRPPKP WDPVDAEMVV DLAQAMGPLK GTEGEPLEEQ LDESLVRTVA LSSAGGLSPM
AVLGAVAAQE VLKAISGKFM PLDQWLYFDA LDCLPEDGDP FPNPEDCAPR RCRYDGQTAV
FGADFQEKLS HQHYLLVGAG AVGCELLKGF ALMGLGAGGS GGVTVADMDH VELSNLSRQF
LFRSQDIHRQ KAEVAAEATR RLNADLQVTP LNLQLDPTTE HIFGDDFFSG VDGVAAAVDT
FEARDYVAAR CTHFLKPLLE AGTTGTRGSA GVFIPHVTEN YKAPSDAASE DAPDPVCTVR
YIPATTEHTV QWAKGEFDDL FCESAKTINS HPHALSSPEG LVKSQKQPLL QTMRGVLTER
PQTWRDCVLW ALGHWQLRFH YGITQLLRTY PPDKVQEDGT PFWSGPKQCP QPLEFDASQD
THLLYVLAAA NLYAQMHRLP GSQDQTALRG LLNLLPLPDP QNLDRIFASE LELDSPSGCK
QLHEDLKTWS KGPSLEPLTF EKDNDSNFHV DFVVAAASLR AQNYAIPVAS HAETKRIVGR
IIPAVVTTTA AVAGLVGLEL YKVVGGPRPR HAFRHSYLHL AENYFSRWVP KAPDIQKFHH
LKWTCWDRLE VPAGQPERTL ESLLAHIQEL QGLRVTMLLH GSAQLYSAGW SEEKQARHLS
RRVTELVKKE PGQRVLVLEL GYEGEEYDTN FPRLHYKL
//
