ID W5PS49_SHEEP Unreviewed; 301 AA.
AC W5PS49;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Guanine nucleotide-binding protein G(q) subunit alpha {ECO:0000256|ARBA:ARBA00040847};
DE AltName: Full=Guanine nucleotide-binding protein alpha-q {ECO:0000256|ARBA:ARBA00042116};
GN Name=GNAQ {ECO:0000313|Ensembl:ENSOARP00000013278.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000013278.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000013278.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000013278.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000013278.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004193};
CC Lipid-anchor {ECO:0000256|ARBA:ARBA00004193}. Golgi apparatus
CC {ECO:0000256|ARBA:ARBA00004555}. Nucleus membrane
CC {ECO:0000256|ARBA:ARBA00004126}.
CC -!- SIMILARITY: Belongs to the G-alpha family. G(q) subfamily.
CC {ECO:0000256|ARBA:ARBA00007976}.
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DR EMBL; AMGL01049237; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01049238; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01049239; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01049240; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01049241; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01049242; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01049243; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01049244; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01049245; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01049246; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5PS49; -.
DR SMR; W5PS49; -.
DR STRING; 9940.ENSOARP00000013278; -.
DR PaxDb; 9940-ENSOARP00000013278; -.
DR Ensembl; ENSOART00000013473.1; ENSOARP00000013278.1; ENSOARG00000012393.1.
DR eggNOG; KOG0085; Eukaryota.
DR HOGENOM; CLU_014184_6_0_1; -.
DR OMA; EHQSEFY; -.
DR Proteomes; UP000002356; Chromosome 2.
DR Bgee; ENSOARG00000012393; Expressed in hippocampal formation and 53 other cell types or tissues.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IEA:InterPro.
DR GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR CDD; cd00066; G-alpha; 1.
DR Gene3D; 1.10.400.10; GI Alpha 1, domain 2-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR000654; Gprotein_alpha_Q.
DR InterPro; IPR001019; Gprotein_alpha_su.
DR InterPro; IPR011025; GproteinA_insert.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10218; GTP-BINDING PROTEIN ALPHA SUBUNIT; 1.
DR PANTHER; PTHR10218:SF316; GUANINE NUCLEOTIDE-BINDING PROTEIN G(Q) SUBUNIT ALPHA; 1.
DR Pfam; PF00503; G-alpha; 1.
DR PRINTS; PR00318; GPROTEINA.
DR PRINTS; PR00442; GPROTEINAQ.
DR SMART; SM00275; G_alpha; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47895; Transducin (alpha subunit), insertion domain; 1.
DR PROSITE; PS51882; G_ALPHA; 1.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Transducer {ECO:0000256|ARBA:ARBA00023224}.
SQ SEQUENCE 301 AA; 35422 MW; 0CB22D4CC93DBBD3 CRC64;
MRIIHGSGYS DEDKRGFTKL VYQNIFTAMQ AMIRAMDTLK IPYKYEHNKA HAQLVREVDV
EKVSAFENPY VDAIKSLWND PGIQECYDRR REYQLSDSTK YYLNDLDRVA DPAYLPTQQD
VLRVRVPTTG IIEYPFDLQS VIFRMVDVGG QRSERRKWIH CFENVTSIMF LVALSEYDQV
LVESDNENRM EESKALFRTI ITYPWFQNSS VILFLNKKDL LEEKIMYSHL VDYFPEYDGP
QRDAQAAREF ILKMFVDLNP DSDKIIYSHF TCATDTENIR FVFAAVKDTI LQLNLKEYNL
V
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