ID W5PUF6_SHEEP Unreviewed; 1165 AA.
AC W5PUF6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Laminin subunit beta-3 {ECO:0008006|Google:ProtNLM};
GN Name=LAMB3 {ECO:0000313|Ensembl:ENSOARP00000014087.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000014087.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000014087.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000014087.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000014087.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMGL01022786; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01022787; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01022788; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01022789; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9940.ENSOARP00000014087; -.
DR PaxDb; 9940-ENSOARP00000014087; -.
DR Ensembl; ENSOART00000014294.1; ENSOARP00000014087.1; ENSOARG00000013143.1.
DR eggNOG; KOG0994; Eukaryota.
DR HOGENOM; CLU_001560_0_0_1; -.
DR OMA; EITHPEA; -.
DR Proteomes; UP000002356; Chromosome 12.
DR Bgee; ENSOARG00000013143; Expressed in lung and 52 other cell types or tissues.
DR CDD; cd00055; EGF_Lam; 3.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR10574:SF268; LAMININ SUBUNIT BETA-3; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00053; Laminin_EGF; 3.
DR Pfam; PF00055; Laminin_N; 1.
DR SMART; SM00180; EGF_Lam; 3.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01248; EGF_LAM_1; 1.
DR PROSITE; PS50027; EGF_LAM_2; 2.
DR PROSITE; PS51117; LAMININ_NTER; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..1165
FT /note="Laminin subunit beta-3"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004869497"
FT DOMAIN 22..249
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 318..380
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 525..571
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT REGION 481..513
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 719..756
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 942..972
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1036..1063
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 730..744
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 348..357
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 525..537
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 527..544
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 546..555
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 1165 AA; 127911 MW; 1592B67A482F9A5A CRC64;
MRPLLLLYFG LPSLLCAQQA CSRGACYPPV GDLLIGRTRF LRASSTCGLT KPETYCAQYG
EWQMKCCKCD SRLAHNYNGH RVENVVSSSG PMRWWQSQND VSPVFLQLDL DRKFQLQDIM
MDFKGPVPAG MLIERSSDFG KTWQVYQYLA SDCGSTFPWV RQGQPQGWQD ARCQTLPQRP
NGRPNGAKVQ LNLMDLASGI PATQSQKIQE LGEITNLRVN FTKLAPVPQR GYHPPSAYYA
VSQLRLQGSC LCHGHADRCT PSSRTPARGT LKSHLEVHEV CVCQHNTAGP NCERCAPFYN
NRPWRPAEDQ DPHECQRCDC NGHSETCHFD PAVFAASQGA HGGVCDNCRD HTEGRNCERC
QLHYFRNRRP GAPIQETCIL CSGLNRAHVP GDSHALLVSW SLCRTFRYSS RCQISPPGVT
KHIHNGQYRK HSDSAMKGAQ VLGPTETFVL HNMCXPRVLA PLTAGGSEAR ACARGAELGP
RLHEGAADPK TPRPDVLSRA LPGRLSPSLA PGPQPLTIFS PAPACDCDFR GTEGPGCDKA
SGRCLCRPGL TGPRCDQCQR GYCDRAPVCV ACHPCFQTYD GGLRERALRL AGLRNASAGL
WPRPGPEDHG LASRMQDAKS KMEQIQATLG DALVTEQEVA QVANAIFSIR RTLQALKLDL
PLEEETLNLP GDLGSLDRSF NHLLVTYQSK REQFEKMSSA DPSGAFRVLT AAHQRSSQAA
QQVLDSSRRL LPLRDSRREA ERLEQQVAGG SGAGGPQLAA LRLEMASVPD LTPAINQLCG
GSREMPCTPG ACPGELCPRD NGTACGSRCC GGAPPRAGGA LRMAGQVAEQ LRAFGAQLQQ
TKQMVGVARD TIPEVSADLP TWPHSQVSAS RSQMEEDVRR TRLLIRQVRD FLSDPDTDTA
TIQEVSEAVL ALWLPTDSAT VLRKMNEIQA IAARLPNVDL VLSQTKQDVA RARRLQAEAE
QARSRAHAVE GQVEEVLGAL QQGTLALQEA QDTMRGTGRS LRLIQDRVAE VQQVLGPAER
LVTSMTEQLG GFRARMEELG HRARQQQAQA AQARQLAEEA SEAALSAQEG FGRVKQKYAE
LKDRLDQSSR LGEQGSRILS VKTEAEELFG ETMAMMDRMR DMESELLRGS QAIVLRSADL
TGLEQRVEQI RNYINGRVLY YATCK
//
