ID   W5PW55_SHEEP            Unreviewed;       595 AA.
AC   W5PW55;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 55.
DE   RecName: Full=RRM domain-containing protein {ECO:0000259|PROSITE:PS50102};
GN   Name=A1CF {ECO:0000313|Ensembl:ENSOARP00000014688.1};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000014688.1, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000014688.1, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000014688.1,
RC   ECO:0000313|Proteomes:UP000002356};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA   Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000014688.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   EMBL; AMGL01063129; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_004020057.1; XM_004020008.3.
DR   RefSeq; XP_011957848.1; XM_012102458.2.
DR   AlphaFoldDB; W5PW55; -.
DR   SMR; W5PW55; -.
DR   STRING; 9940.ENSOARP00000014688; -.
DR   PaxDb; 9940-ENSOARP00000014688; -.
DR   Ensembl; ENSOART00000014905.1; ENSOARP00000014688.1; ENSOARG00000013695.1.
DR   GeneID; 101118147; -.
DR   CTD; 29974; -.
DR   eggNOG; KOG0117; Eukaryota.
DR   HOGENOM; CLU_022960_5_1_1; -.
DR   OMA; YATYEVY; -.
DR   OrthoDB; 3184171at2759; -.
DR   Proteomes; UP000002356; Chromosome 22.
DR   Bgee; ENSOARG00000013695; Expressed in liver and 17 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   CDD; cd19900; DSRM_A1CF; 1.
DR   CDD; cd12486; RRM1_ACF; 1.
DR   CDD; cd12490; RRM2_ACF; 1.
DR   CDD; cd12498; RRM3_ACF; 1.
DR   Gene3D; 3.30.160.20; -; 1.
DR   Gene3D; 3.30.70.330; -; 3.
DR   InterPro; IPR044461; A1CF_DSRM.
DR   InterPro; IPR034538; ACF_RRM1.
DR   InterPro; IPR006535; HnRNP_R/Q_splicing_fac.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   NCBIfam; TIGR01648; hnRNP-R-Q; 1.
DR   PANTHER; PTHR21245:SF8; APOBEC1 COMPLEMENTATION FACTOR; 1.
DR   PANTHER; PTHR21245; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; 1.
DR   Pfam; PF14709; DND1_DSRM; 1.
DR   Pfam; PF00076; RRM_1; 3.
DR   SMART; SM00360; RRM; 3.
DR   SUPFAM; SSF54768; dsRNA-binding domain-like; 1.
DR   SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR   PROSITE; PS50102; RRM; 3.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176}.
FT   DOMAIN          56..134
FT                   /note="RRM"
FT                   /evidence="ECO:0000259|PROSITE:PS50102"
FT   DOMAIN          136..218
FT                   /note="RRM"
FT                   /evidence="ECO:0000259|PROSITE:PS50102"
FT   DOMAIN          231..303
FT                   /note="RRM"
FT                   /evidence="ECO:0000259|PROSITE:PS50102"
SQ   SEQUENCE   595 AA;  65199 MW;  FEBD7E0F2364872F CRC64;
     MESNHKSGDG LSGTQKEAAL RALVQRTGYS LVQENGQRKY GGPPPGWDAA PPERGCEIFI
     GKLPRDLFED ELIPLCEKIG KIYEMRMMMD FNGNNRGYAF VTFSNKQEAK NAIKQLNNYE
     IRNGRLLGVC ASVDNCRLFV GGIPKTKKRE EILSEMKKVT EGVVDVIVYP SAADKTKNRG
     FAFVEYENHR AAAMARRKLL PGRIQLWGHP IAVDWAEPEV EVDEDTMSSV KILYVRNLML
     STSEEMIEKE FNNIKPGAVE RVKKIRDYAF VHFTNREDAV EAMKALNGKV LDGSPIEVTL
     AKPVDKDSYV RYTRGTGGRG AMLQGEYTYS LGHIYDPTTT YLGAPVFYAP QAYTAIPSLH
     FPATKGHLGS RAIIRAPSVR EIYMNVPVGA AGVRGLGGRG YLAYTGLGRG YQVKGDKRED
     RLYDLLPGME LTPMNPATLK PQGIKLAPQI LEEICQKNNW GQPVYQLHSA IGQDQRQLFL
     YKITIPALAS QNPAIHPFTP PKLSAYVDEA KTYAAEYTLQ ALGIPTDGAD AQTAAAAAAA
     AAAFPGYAVP SPTASVSAAQ LKQAVTLGQD LAAYAAYEVY PTFAVTARGD GYGTF
//