ID W5PXC5_SHEEP Unreviewed; 1990 AA.
AC W5PXC5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=PH domain-containing protein {ECO:0000259|PROSITE:PS50003};
GN Name=TRIOBP {ECO:0000313|Ensembl:ENSOARP00000015109.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000015109.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000015109.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000015109.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000015109.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AMGL01083894; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01083895; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR SMR; W5PXC5; -.
DR STRING; 9940.ENSOARP00000015109; -.
DR PaxDb; 9940-ENSOARP00000015109; -.
DR Ensembl; ENSOART00000015329.1; ENSOARP00000015109.1; ENSOARG00000014071.1.
DR eggNOG; KOG4807; Eukaryota.
DR HOGENOM; CLU_231134_0_0_1; -.
DR OMA; YIPPAVC; -.
DR Proteomes; UP000002356; Chromosome 3.
DR Bgee; ENSOARG00000014071; Expressed in placental caruncle and 51 other cell types or tissues.
DR CDD; cd13275; PH_M-RIP; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR039597; M-RIP_PH.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR17271; PLECKSTRIN HOMOLOGY PH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR17271:SF10; TRIO AND F-ACTIN-BINDING PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 1405..1501
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..1175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1230..1376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1504..1640
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1705..1724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1735..1835
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1911..1984
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 83..106
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 187..201
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..237
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 261..289
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 295..323
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 333..357
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..524
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 540..558
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 568..633
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 811..829
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 926..941
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 947..1019
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1271..1320
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1327..1365
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1505..1525
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1559..1573
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1578..1623
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1990 AA; 218378 MW; 986503D67166C5E1 CRC64;
CSQEPGRPSS AEVPYCDLPR RRPAPEDPLS TPTSSCQSVV GPGRGPEPER GPPAGLLAEG
FTAASRSREP EAAPYFEGLA SSPCGSFNES PDSGTSEAPD DTSDSSLVDW DTVERREEAP
SGDNFTVMIP RKSQEVPRAD GARKAPPLLT QAPVGGGDTA GRKKEGSGGG NRSAGQHWAK
LRAFPWARPR PAPPPASPAT PQSGPRSATS QASSLHRSAP RNTVQAVSPQ RGASRASSPL
RIIQRDKQRD TPRATSPSRV APRDNLRTSS SQQDTPKTSS TQRDTPRATS PSRVAPRDNL
RTSSSQQDTP KTSSTQRDTP RATSPSRVAP RDDLRTLSTQ QDTPKTSSTQ RDTPRATSPS
RAAPRDKLRT SSTQQDTPKT SSTQRNTPRA TSPSRVVPQV SPRTSSTQRN NPWVSSPPRA
TQQDTSRASY TQQDNPQTPV PTCTPQRGNP RPSCAPQNTP RSSSAQRDNP KTSCTQRDNP
KSSSSRRENP GSTSCQGCTQ QDNPRASSPD RSSQRNNPRN ASPHRTNKDI PWASFPLRPT
QSDGPRTSSP SRSKQSEVPW ASIALRPTQG DRPQTSSPAR PAQRDSPQSS SAQLTIPATA
TSHNPGHHGA SRTSSPLHPT PRGAPQTSSE LPQPPCAVCI GHRDAPRASS PPRYLQHDPF
PFFPDPHTSE SESPHHDPPY MPPAVCIGHR DAPRASPPPR HTQFDPFPFL PDTSDAENQS
LQHDPPQFPP PVCIGYRDAP RASSPPRQAP EPSLLFLDLP RASTESLVPS MDSLREPPAI
PTPVCIGHRD APSFSSPPRQ PPEPSLFFQD PPGTSMESLA PSSDSLRGSP MLPPQVCIGH
RDAPRASSPP RHPPSDLALL APSPPPGSSG GSWGSAPPGE IRHNLEREEY SVLADLPPPR
RLAQREPGPQ GSNGGPTLSP GAEVERLFGQ ERRKSEAPGA FQARDEGRSQ WPSQGQSQLL
RRQSSPALGR EASTKLGSFQ TDPTQPGAWS PTHPLTSSSG NQPPSEWLQG SSPPPRTSAR
TPEREQRTQR PLECGRVGPR QPLGGWRSQE EPPGSRGPHG CLERGWRSRE EGPGLRGWQG
LGESSRGPAR VPEGVWRGPP RESESWSRGG PPPAGPAGRG GGSLQELSSP RQPVSPPENS
RAGPGEFSKS QRPETLPAVG RGAEEACPHL CGPKRQAEFD WRDLVSLLGV PREGMWSRPE
EPTLTSHLPR LDWEGLLELL QAQLLHKDPA GHWVGPGQAS PGTKDTLELE QDRHSQPEGG
AGAALVNGYD PGQWPQSSAQ PSSPTSISTQ WPKTKVTSGP ESSATTGLEE TGQLGSRSPA
EGPSSPRREF QSKEPEESER SRGQDSLTDQ KQADSADKRP AEGKAGSPLK GRLVTSWRMP
GDRPTLFNPF LLSLGVLRWQ RPDLLNFKKG WMSILDEPGE WKKHWFVLTD SSLKYYRDST
AEEADELDGE IDLRSCTDVT EYAVQRNYGF QIHTKDAVYT LSAMTSGIRR NWIEALRKTV
RPTSAPDVTK LSDCNKENTL HSYGTPKGSL KAGEQRVGSE VISRGGPRKA DGQRQSLDYV
ELSPLTQGSP QRARTLARAL DRPAKQEELE RDLAQRSEER RKWFEATDSR AAEKHRAPEP
RAGEGPRRVL GAPLTEDQQS RLSEEIEKKW QELEKLPLRE NKRVPLTALL NQGRGERRGA
PSDSHEALEK EVQSLRAQLE AWRLQGEAPQ GAPKSQEDGH IPPGYISQEA CERSLAEMES
SHQQVMQELQ RHHERELQRL QQEKEWLLAE ETAATASAIE AMKKAYQEEL SRELNKTRTL
QQGPDGLRKQ HQSDVEALKR ELQVLSEQYS QKCLEIGALT RQAEEREHTL RRCQQEGQEL
LRHNQELHTR LSEEIDRLRS FIASPGLLAG AWGLGLGRSQ DHPRLWLCVL LRVKENELLY
LKKEVQCLRD ELQMMQKDKR FTSGKYQDVY VELNHIKTRS EREIEQLKEH LRLAMAALQE
KEAVRNSLAE
//
