ID W5PYQ1_SHEEP Unreviewed; 838 AA.
AC W5PYQ1;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Phospholipase A-2-activating protein {ECO:0008006|Google:ProtNLM};
GN Name=PLAA {ECO:0000313|Ensembl:ENSOARP00000015586.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000015586.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000015586.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000015586.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000015586.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the WD repeat PLAP family.
CC {ECO:0000256|ARBA:ARBA00008495}.
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DR EMBL; AMGL01050795; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5PYQ1; -.
DR SMR; W5PYQ1; -.
DR STRING; 9940.ENSOARP00000015586; -.
DR PaxDb; 9940-ENSOARP00000015586; -.
DR Ensembl; ENSOART00000015817.1; ENSOARP00000015586.1; ENSOARG00000014522.1.
DR eggNOG; KOG0301; Eukaryota.
DR HOGENOM; CLU_011791_2_0_1; -.
DR OMA; RTFDTCD; -.
DR Proteomes; UP000002356; Chromosome 2.
DR Bgee; ENSOARG00000014522; Expressed in longissimus thoracis muscle and 56 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 3.10.20.870; PFU (PLAA family ubiquitin binding), C-terminal domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR015155; PFU.
DR InterPro; IPR038122; PFU_sf.
DR InterPro; IPR013535; PUL_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19849; PHOSPHOLIPASE A-2-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR19849:SF0; PHOSPHOLIPASE A-2-ACTIVATING PROTEIN; 1.
DR Pfam; PF09070; PFU; 1.
DR Pfam; PF08324; PUL; 1.
DR Pfam; PF00400; WD40; 7.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS51394; PFU; 1.
DR PROSITE; PS51396; PUL; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 143..173
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 182..214
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 266..298
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 405..504
FT /note="PFU"
FT /evidence="ECO:0000259|PROSITE:PS51394"
FT DOMAIN 576..837
FT /note="PUL"
FT /evidence="ECO:0000259|PROSITE:PS51396"
SQ SEQUENCE 838 AA; 91076 MW; ECF1D3E753AC68DD CRC64;
MNSGVLVRVA VSLGPLGAPL PCRPSAPAVS GPTGAMASGS CRYRLSCSLS GHELDVRGLV
CCLYPPGAFV SVSRDRTTRL WVPDSPNRGF TEMHCMSGHS NFVSCVCIIP SSDVYPHGLI
ATGGNDHNIC IFSLESPAPL YVLKGHKNTV CSLSSGKFGT LLSGSWDTTA KVWLNDKCMM
TLQGHTAAVW AVKILPEQGL MLTGSADKTI KLWKAGRCER TFSDFNTGHE DCVRGLAILS
ETEFLSCAND ASIRRWQITG ECLEVFYGHT NYIYSISVFP NCKDFVTTAE DRSLRIWKHG
ECAQTIRLPA QSIWCCCVLD NGDIVVGASD GIIRVFTESE DRTASAEEIK AFERELSQAT
IDSKTGDLGD INAEQLPGRE HLNEPGTREG QTRLIRDGEK VEAYQWSVNE RRWIKIGDVV
GSSGASQQTS GKVLYEGKEF DYVFSIDVNE GGPSYKLPYN ITDDPWLAAY NFLQKNDLNP
MFLDQVAKFI IDNTKGQMLG LGNTSFSDPF TGTGGGRYVP GSSSGSSNTL PAADPFTGGG
RYVPGSASMG TTMAGVDPFT AGNSAYQSAA SKTVNIYFPK KEAVTFDQAN PTQILGKLKE
LNGTASEEKK LTEDDLVLLE KILSLICNNS SEKPTAQQLQ ILWKAVNWPE DIVFPALDIL
RLSIKHPSVN ENFCNEKEGA RFSSHLVSLL NPRGKPANQL LALRTFCNCF VGQAGQKLMI
SQRESLLSHA IELKSGSNKN IHIALATLTL NYSVCFHKDH NIEGKAQCLS VISTVLEVVQ
DLEATFRLLV ALGTLISDDS NAVQLAKSLG VDSQIKKYAS VSEPAKVSEC CRLILNLL
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