ID W5PZG8_SHEEP Unreviewed; 741 AA.
AC W5PZG8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Ig-like domain-containing protein {ECO:0000259|PROSITE:PS50835};
GN Name=PECAM1 {ECO:0000313|Ensembl:ENSOARP00000015854.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000015854.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000015854.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000015854.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000015854.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; AMGL01018954; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01018955; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5PZG8; -.
DR Ensembl; ENSOART00000016087.1; ENSOARP00000015854.1; ENSOARG00000014779.1.
DR Proteomes; UP000002356; Chromosome 11.
DR Bgee; ENSOARG00000014779; Expressed in mitral valve and 54 other cell types or tissues.
DR ExpressionAtlas; W5PZG8; baseline.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR040878; IL-40-like_Ig.
DR PANTHER; PTHR11481:SF60; IG-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR11481; IMMUNOGLOBULIN FC RECEPTOR; 1.
DR Pfam; PF13895; Ig_2; 3.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF17736; Ig_C17orf99; 1.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 4.
DR PROSITE; PS50835; IG_LIKE; 4.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..741
FT /note="Ig-like domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004869645"
FT TRANSMEM 602..624
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 35..120
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 236..315
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 328..403
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 499..591
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 719..741
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 741 AA; 82890 MW; 3E4FC1F47EF0F006 CRC64;
MQLRWTQRGM MWLGALLTLL LCSSLKGQEN SFTINSIHMQ ILPQNTVQNG ENLTLQCLVD
VSTTSPVQPL HQVLFYKDDV LLRNISSRTN RESYLIPHVR VCDSGRYKCT VKLNNKEKAT
PEYEVWVKGV SDPRVTLDKK EVIEGGVVVV NCSVPEEKAP VHFTIEKFEL NIRSAKKKRE
KTSQNQNFVT LEFTVEEQDR AIFFQCQAKI FSGSNVESSR PMRSELVTVR ESFSNPKFHI
IPEGKITEGD DLQVKCTVQV THQAQSFPEI IIQKDREIVA HNSLSSEAVY SVMATTEHNG
NYTCKVEASR ISKVSSIVVN ITELFSKPKL ESSATHLDQG ENLNLWCSIP GAPPANFTIQ
KGGMTVSQTQ NFSKRVAEWD SGLYTCVAGV GRVVKRSNTV QITVCEMLSK PSIFHDSRSE
VIKGQTIEVS CQSINGTAPI FYQLSNTSKP VANQSMGSNE PAIFRDKPTK DVEYWCSADN
CHSHSKMFSE VLRVKVIAPV DEAKLSILLK EEVESGMPIV LRCSVSEGSS PITYKFYKGK
ESKPFHQETL NATLAIWHED TASKEHEGQY YCTASNRANL SKHVIQSNTL TIRVYLAPWK
KGLIAVVVIG VIIATLVFGA RCYFLKKAKA KQMPVEMSRP AVPLLNSNNE KTLSDASTEA
DRHYGFNEDV GNHAMKPLNE NKAEPLTLDV EYTEVEVTSP EPHRGLGTKG TETVYSEIRK
ADPVDSLKRN YSNRQGNFSK T
//
