ID W5Q705_SHEEP Unreviewed; 360 AA.
AC W5Q705;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Hcy-binding domain-containing protein {ECO:0000259|PROSITE:PS50970};
GN Name=BHMT2 {ECO:0000313|Ensembl:ENSOARP00000018497.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000018497.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000018497.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000018497.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000018497.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Involved in the regulation of homocysteine metabolism.
CC {ECO:0000256|PIRNR:PIRNR037505}.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|PIRNR:PIRNR037505,
CC ECO:0000256|PIRSR:PIRSR037505-2};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRNR:PIRNR037505,
CC ECO:0000256|PIRSR:PIRSR037505-2};
CC -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo
CC pathway; L-methionine from L-homocysteine (BhmT route): step 1/1.
CC {ECO:0000256|ARBA:ARBA00005137, ECO:0000256|PIRNR:PIRNR037505}.
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|PIRNR:PIRNR037505}.
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DR EMBL; AMGL01101749; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5Q705; -.
DR SMR; W5Q705; -.
DR STRING; 9940.ENSOARP00000018497; -.
DR PaxDb; 9940-ENSOARP00000018497; -.
DR Ensembl; ENSOART00000018759.1; ENSOARP00000018497.1; ENSOARG00000017231.1.
DR eggNOG; KOG1579; Eukaryota.
DR HOGENOM; CLU_047457_0_0_1; -.
DR OMA; ENMESKW; -.
DR UniPathway; UPA00051; UER00083.
DR Proteomes; UP000002356; Chromosome 7.
DR Bgee; ENSOARG00000017231; Expressed in metanephros cortex and 15 other cell types or tissues.
DR GO; GO:0008172; F:S-methyltransferase activity; IEA:UniProt.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009086; P:methionine biosynthetic process; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.20.20.330; Homocysteine-binding-like domain; 1.
DR InterPro; IPR017226; Betaine-hCys_S-MeTrfase_BHMT.
DR InterPro; IPR003726; HCY_dom.
DR InterPro; IPR036589; HCY_dom_sf.
DR PANTHER; PTHR46120; BETAINE--HOMOCYSTEINE S-METHYLTRANSFERASE 1; 1.
DR PANTHER; PTHR46120:SF3; S-METHYLMETHIONINE--HOMOCYSTEINE S-METHYLTRANSFERASE BHMT2; 1.
DR Pfam; PF02574; S-methyl_trans; 1.
DR PIRSF; PIRSF037505; Betaine_HMT; 1.
DR SUPFAM; SSF82282; Homocysteine S-methyltransferase; 1.
DR PROSITE; PS50970; HCY; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PIRNR:PIRNR037505,
KW ECO:0000256|PIRSR:PIRSR037505-2};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000256|PIRNR:PIRNR037505};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR037505};
KW Zinc {ECO:0000256|PIRNR:PIRNR037505, ECO:0000256|PIRSR:PIRSR037505-2}.
FT DOMAIN 11..305
FT /note="Hcy-binding"
FT /evidence="ECO:0000259|PROSITE:PS50970"
FT BINDING 208
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR037505-2,
FT ECO:0000256|PROSITE-ProRule:PRU00333"
FT BINDING 290
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR037505-2,
FT ECO:0000256|PROSITE-ProRule:PRU00333"
FT BINDING 291
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR037505-2,
FT ECO:0000256|PROSITE-ProRule:PRU00333"
SQ SEQUENCE 360 AA; 39975 MW; CCCFDE21E8F1063D CRC64;
MAPIEGPRVK KGLLKRLDSG EVVVGDGSYL LTLEKRGYVK AGLWTPEAVV EHPNAVCQLH
MEFLRAGSDV MQTFTFSASE DNMESQWEAV NTAACDLARE VADKGDALVV GGICQTSLYA
HHKDEVRIKK LFQLQLEIFA RKNVDFLIAQ YFENAVEAVW AVEVLKESGK PVAATVCVGP
EGDMPGVTPG ECDVKLRKAV CASTKLHCTF GPWTSLETMS LMKEALQAAG LKEHLMVQSL
GFHMPDCGNR GFLDIPEYPF ALEPRVATRW DIQKYTREAY SPGVRYIGGC CGFEPYHIRA
IAERGFLPPA SEKYGSWGSG LNTHTKPWIR ARHRARREYW ENLWPASGRP LCPSLSKPDA
//
