ID W5QAJ6_SHEEP Unreviewed; 217 AA.
AC W5QAJ6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=GRB2-related adapter protein {ECO:0008006|Google:ProtNLM};
GN Name=GRAP {ECO:0000313|Ensembl:ENSOARP00000019741.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000019741.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000019741.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000019741.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000019741.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AMGL01018279; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01018280; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01018281; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSOART00000020014.1; ENSOARP00000019741.1; ENSOARG00000018391.1.
DR HOGENOM; CLU_073617_1_0_1; -.
DR Proteomes; UP000002356; Chromosome 11.
DR Bgee; ENSOARG00000018391; Expressed in submandibular lymph node and 52 other cell types or tissues.
DR ExpressionAtlas; W5QAJ6; baseline.
DR CDD; cd09941; SH2_Grb2_like; 1.
DR CDD; cd11948; SH3_GRAP_N; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR035645; GRAP_N_SH3.
DR InterPro; IPR043539; Grb2-like.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46037:SF2; GRB2-RELATED ADAPTER PROTEIN; 1.
DR PANTHER; PTHR46037; PROTEIN ENHANCER OF SEVENLESS 2B; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF00018; SH3_1; 2.
DR PRINTS; PR00499; P67PHOX.
DR PRINTS; PR00401; SH2DOMAIN.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50002; SH3; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..58
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 60..158
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 158..217
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
SQ SEQUENCE 217 AA; 25292 MW; BF7834DEEA56B696 CRC64;
MESVALYSFQ ATESDELGFN KGDTLKILNM EDDQNWYKAE LRGAEGFVPK NYIRVKPHPW
YSGRISRQLA EEILRKRNHP GAFLIRESES SPGEFSVSVN YGDQVQHFKV LREPSGKYYL
WEEKFNSLNE LVAFYRTTTI AKKRQVFLQD EEPLPKPPRA CFAQAQFDYS AQDPSQLSFR
HGDIIEVLER LDPCWWRGRL SGRIGFFPRG FVPPXHQ
//
