ID W5QAK5_SHEEP Unreviewed; 654 AA.
AC W5QAK5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Protein inhibitor of activated STAT 1 {ECO:0008006|Google:ProtNLM};
GN Name=PIAS1 {ECO:0000313|Ensembl:ENSOARP00000019750.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000019750.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000019750.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000019750.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000019750.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein sumoylation.
CC {ECO:0000256|ARBA:ARBA00004718}.
CC -!- SIMILARITY: Belongs to the PIAS family.
CC {ECO:0000256|ARBA:ARBA00005383}.
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DR EMBL; AMGL01101937; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01101938; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01101939; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5QAK5; -.
DR SMR; W5QAK5; -.
DR STRING; 9940.ENSOARP00000019750; -.
DR PaxDb; 9940-ENSOARP00000019750; -.
DR Ensembl; ENSOART00000020023.1; ENSOARP00000019750.1; ENSOARG00000018393.1.
DR eggNOG; KOG2169; Eukaryota.
DR HOGENOM; CLU_020768_3_0_1; -.
DR OMA; LRIVTPC; -.
DR UniPathway; UPA00886; -.
DR Proteomes; UP000002356; Chromosome 7.
DR Bgee; ENSOARG00000018393; Expressed in gastric lymph node and 54 other cell types or tissues.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0016925; P:protein sumoylation; IEA:UniProtKB-UniPathway.
DR GO; GO:0060255; P:regulation of macromolecule metabolic process; IEA:UniProt.
DR CDD; cd16818; SP-RING_PIAS1; 1.
DR Gene3D; 2.60.120.780; PINIT domain; 1.
DR Gene3D; 1.10.720.30; SAP domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR023321; PINIT.
DR InterPro; IPR038654; PINIT_sf.
DR InterPro; IPR003034; SAP_dom.
DR InterPro; IPR036361; SAP_dom_sf.
DR InterPro; IPR004181; Znf_MIZ.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR10782:SF11; E3 SUMO-PROTEIN LIGASE PIAS1; 1.
DR PANTHER; PTHR10782; ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF14324; PINIT; 1.
DR Pfam; PF02891; zf-MIZ; 1.
DR SMART; SM00513; SAP; 1.
DR SUPFAM; SSF68906; SAP domain; 1.
DR PROSITE; PS51466; PINIT; 1.
DR PROSITE; PS50800; SAP; 1.
DR PROSITE; PS51044; ZF_SP_RING; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00452}.
FT DOMAIN 14..48
FT /note="SAP"
FT /evidence="ECO:0000259|PROSITE:PS50800"
FT DOMAIN 127..291
FT /note="PINIT"
FT /evidence="ECO:0000259|PROSITE:PS51466"
FT DOMAIN 323..408
FT /note="SP-RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51044"
FT REGION 468..514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 602..633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 483..514
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 654 AA; 72095 MW; 91AEAACE59E4DA72 CRC64;
LLTLNVCFVS KQMVMSLRVS ELQVLLGYAG RNKHGRKHEL LTKALHLLKA GCSPAVQMKI
KELYRRRFPQ KIMTPADLSI PNVHSSPMPA TLSPSTIPQL TYDGHPASSP LLPVSLLGPK
HELELPHLTS ALHPVHPDIK LQKLPFYDLL DELIKPTSLA SDNSQRFRET CFAFALTPQQ
VQQISSSMDI SGTKCDFTVQ VQFRFCLSET SCPQEDHFPP NLCVKVNTKP CSLPGYLPPT
KNGVEPKRPS RPINITSLVR LSTTVPNTIV VSWTAEIGRN YSMAVYLVKQ LSSTVLLQRL
RAKGIRNPDH SRALIKEKLT ADPDSEIATT SLRVSLLCPL GKMRLTIPCR ALTCSHLQCF
DATLYIQMNE KKPTWVCPVC DKKAPYEHLI IDGLFMEILK YCTDCDEIQF KEDGSWAPMR
SKKEVQEVSA SYNGVDGCLS STLEHQVASH HQSSNKSKKV EVIDLTIDSS SDEEEEEPSA
KRTCPSLSPT SPLNNKGILS LPHQASPVSR TPSLPAVDTS YINTSLIQDY RHPFHMTPMP
YDLQGLDFFP FLSGDNQHYN TSLLAAAAAA VSDDQDLLHS SRFFPYASSQ MFLDQLSAGG
STSLPTTNGS SSGSNSSLVS SNSLRESHGH TVANRSSTDT AAIFGIIPDI ISLD
//