ID W5QBJ4_SHEEP Unreviewed; 1135 AA.
AC W5QBJ4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Small G protein signaling modulator 1 {ECO:0008006|Google:ProtNLM};
GN Name=SGSM1 {ECO:0000313|Ensembl:ENSOARP00000020091.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000020091.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000020091.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000020091.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000020091.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RUTBC family.
CC {ECO:0000256|ARBA:ARBA00034124}.
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DR EMBL; AMGL01039672; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01039673; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01039674; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01039675; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5QBJ4; -.
DR SMR; W5QBJ4; -.
DR STRING; 9940.ENSOARP00000020091; -.
DR PaxDb; 9940-ENSOARP00000020091; -.
DR Ensembl; ENSOART00000020369.1; ENSOARP00000020091.1; ENSOARG00000018712.1.
DR eggNOG; KOG1648; Eukaryota.
DR HOGENOM; CLU_006235_0_0_1; -.
DR OMA; EKWLAMH; -.
DR Proteomes; UP000002356; Chromosome 17.
DR Bgee; ENSOARG00000018712; Expressed in cerebellum and 46 other cell types or tissues.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProt.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR CDD; cd15784; PH_RUTBC; 1.
DR CDD; cd17703; RUN_SGSM1; 1.
DR Gene3D; 1.20.58.900; -; 1.
DR Gene3D; 2.30.29.230; -; 1.
DR Gene3D; 1.10.8.270; putative rabgap domain of human tbc1 domain family member 14 like domains; 1.
DR Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR InterPro; IPR000195; Rab-GAP-TBC_dom.
DR InterPro; IPR035969; Rab-GAP_TBC_sf.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR047344; RUN_SGSM1.
DR InterPro; IPR037745; SGSM1/2.
DR InterPro; IPR021935; SGSM1/2_RBD.
DR PANTHER; PTHR22957:SF187; SMALL G PROTEIN SIGNALING MODULATOR 1; 1.
DR PANTHER; PTHR22957; TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF12068; PH_RBD; 1.
DR Pfam; PF00566; RabGAP-TBC; 1.
DR Pfam; PF02759; RUN; 1.
DR SMART; SM00593; RUN; 1.
DR SMART; SM00164; TBC; 1.
DR SUPFAM; SSF140741; RUN domain-like; 1.
DR SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 2.
DR PROSITE; PS50826; RUN; 1.
DR PROSITE; PS50086; TBC_RABGAP; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 16..169
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT DOMAIN 603..1068
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000259|PROSITE:PS50086"
FT REGION 189..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 361..397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 417..470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 686..822
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 843..879
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 64..98
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 455..470
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 688..720
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 741..779
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 804..821
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 855..872
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1135 AA; 127603 MW; 0B85EFC1E682F014 CRC64;
QVKQIMEEAV TRKFVHEDSS HIISFCAAVE ACVLHGLRRR AAGFLRSNKI AALFMKVGKS
FPPAEELSRK VQDLEQLIES ARNQIQGLQE NVRKLPKLPN LSPLAIKHLW IRTALFEKVL
DKIVHYLVEN SSKYYEKEAL LMDPVDGPIL ASLLAVGPCA LEYTKMKTSD HFWTDPSADE
LVQRHRIHSS HLRQDSPTPR CQIQKRHSSG SMDDRPSLSA RDYVESLHQN SRATLLYGKN
NVLVQPRDDM EAVPGYLSLH QTADVMTLKW TPNQLMNGSV GDLDYEKSVY WDYAMTIRLE
EIVYLHCHQQ GWVAAAVDSG GTVVLVSQDG IQRPPFRFPK GGHLLQLLSC LENGLLPHGQ
LDPPLWSQRG KGKVFPKLRK RSPQGSSEST SSDKEDDEAT DYVFRIIYPG MQSELVASSP
LGGTPPISAG PARLAGPAGR PVVAEARGRA SRWAQTRRDT TLPTSRLKPQ STVPQDLMDV
SVSNLPSLWQ PSPRQPCSSC SQSGSADGGT TNGCNHERAP LKLLCDNMKY QILSRAFYGW
LAYCRHLSTV RTHLSALVNH MIVSPDLPCD AGQGLTARIW EQYLQDSTSY EEQELLRLIY
YGGIQPEIRK AVWPFLLGHY QFGMTETERK EVDEQIHACY AQTMSEWLGC EAIVRQRERE
SHAAALAKCS SGASLDSHLH RMMHRDSTIS NESSQSCSSG RQNIRLQSDS SSSTQVFESV
DEAEQVEAEG RLEEKPTKIP NGNLVNGTCS PDSGHPSSHN FSSGLSEHSE PSLSTEDSVM
DAQRAAPLVL RPRDSSMDDG QSSEATTSRD EATREELAVQ DSLESDLLAN ESMDEFMSIT
GSLDVALPEK EGPTMEGWRG SEAEKQSQVD SEDNLSEEPE MESLFPALAS LAVTTSANSE
ASPVSSSGVT YSPELLDLYT VNLHRIEKDV QRCDRNYWYF TPANLEKLRN IMCSYIWQHI
EVGYVQGMCD LLAPLLVILD DEALAFSCFT ELMKRMNQNF PHGGAMDTHF ANMRSLIQIL
DSELFELMHQ NGDYTHFYFC YRWFLLDFKR ELIYDDVFSV WETIWAAKHV SSAHYVLFIA
LALVEVYRDI ILENNMDFTD IIKFFNEMAE RHNTKQVLKL ARDLVYKVQT LIENK
//
