ID W5QFW5_SHEEP Unreviewed; 295 AA.
AC W5QFW5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=TGF-beta family profile domain-containing protein {ECO:0000259|PROSITE:PS51362};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000021613.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000021613.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000021613.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000021613.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; AMGL01000928; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01000929; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01000930; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5QFW5; -.
DR SMR; W5QFW5; -.
DR STRING; 9940.ENSOARP00000021613; -.
DR PaxDb; 9940-ENSOARP00000021613; -.
DR Ensembl; ENSOART00000021915.1; ENSOARP00000021613.1; ENSOARG00000020129.1.
DR eggNOG; KOG3900; Eukaryota.
DR HOGENOM; CLU_020515_2_1_1; -.
DR OMA; QPFMVGF; -.
DR Proteomes; UP000002356; Chromosome 1.
DR Bgee; ENSOARG00000020129; Expressed in jejunum and 42 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd19398; TGF_beta_BMP8; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF119; BONE MORPHOGENETIC PROTEIN 8A-RELATED; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 165..295
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 149..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 295 AA; 33171 MW; B9397943E6DD8185 CRC64;
LAVERDPALG HQEPHWKEFH FDLTQIPAGE AVTAAEFRIY KLPSTHPLNQ TLHISMFEVV
LEQSNRESDL FFLDLQTLRS GDEGWLVLDV TAASDRWLLN RNKDLGLRLY VETDDGRSVD
PGLAGLLGRQ APRSKQPFVV TFFRASPCPG PARAPRAARP LKRRPPKRTN ELPPPNRLPG
IFDNVHGSHG RQVCRRHELY VSFQDLGWLD WVIAPQGYSA YYCEGECSFP LDSCMNATNH
AILQSLVHLL KPDAVPKACC APTKLSATSV LYYDSSNNVI LRKHRNMVVR ACGCH
//
