ID W5QH19_SHEEP Unreviewed; 1230 AA.
AC W5QH19;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=PH domain-containing protein {ECO:0000259|PROSITE:PS50003};
GN Name=PLEKHA5 {ECO:0000313|Ensembl:ENSOARP00000022019.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000022019.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000022019.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000022019.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000022019.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AMGL01082984; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01082985; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01082986; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01082987; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012030661.1; XM_012175271.1.
DR AlphaFoldDB; W5QH19; -.
DR SMR; W5QH19; -.
DR STRING; 9940.ENSOARP00000022019; -.
DR PaxDb; 9940-ENSOARP00000022019; -.
DR Ensembl; ENSOART00000022324.1; ENSOARP00000022019.1; ENSOARG00000020496.1.
DR eggNOG; KOG0940; Eukaryota.
DR OMA; AXTESAG; -.
DR Proteomes; UP000002356; Chromosome 3.
DR Bgee; ENSOARG00000020496; Expressed in heart right ventricle and 55 other cell types or tissues.
DR ExpressionAtlas; W5QH19; baseline.
DR CDD; cd13248; PH_PEPP1_2_3; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR040392; PKHA4-7_PH.
DR PANTHER; PTHR12752; PHOSPHOINOSITOL 3-PHOSPHATE-BINDING PROTEIN; 1.
DR PANTHER; PTHR12752:SF3; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 5; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 198..297
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 172..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 488..523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 886..907
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 931..973
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1042..1230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 493..507
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1044..1058
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1059..1086
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1087..1101
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1131..1149
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1165..1180
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1188..1223
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1230 AA; 140099 MW; E1F05B189AF93658 CRC64;
MLRANLKGTE IIFYTSGWKA YRITTNCSSE AASICGCSDM LGRDVSPVSD WQGGRRSDGL
SAFPEGSVPR ALIWEPLKTK QQSQSLLFLP ASPLPVVECN FDGGCHNERK VTCKHPVTGQ
PSQDNCIFVV NEQTVAAMTS EEKKERPLSM INEASNYNMT ADYAVHPMSP VGRTSRASKK
VHNFGKRSNS IKRNPNAPVV RRGWLYKQDS TGMKLWKKRW FVLSDLCLFY YRDEKEEGIL
GSILLPSFQI ALLTSEDHIN RKYAFKAAHP NMRTYYFCTD TGKEMELWMK AMLDAALVQT
EPVKRVDKIT SENAPAKEIN NFPNHRVLIK PEAQNNQKNK EMSRNEEKKA LEAEKYGFQK
DGQDRPLTKI NSVKLNSLSS EYESRSTCPG QTGHYRPVNL SSSENKTVNV SLADLRGGSH
HSTGPLHTEA DRVIQRTNSM QQLEQWIKIQ KGRGHEEETR GVISYQTLPR NMPSHRAPVM
ARYPEGYRTL PRNSKTRPES ICSVTPSAHD KTAGPGAEEK RRSMRDDTMW QLYEWQQRQF
YSRQGTLPRH STLTSPKTMA SISDQTMHSI PTSPSHGSIT AYQGFSPQRT YRSEVSSPIQ
RGDVTIDRRD VTIDRRDVTI DRRDITIDRR DVTIDRRDVT IDRRDVTIDR RDVTIDRRDV
TIDRRDVTID RRDVTIDRRD VTIDRRDVTI DRRHRAHHPK HMYVPDRRSM PAGLTLQSVS
PQSLQGKTLS QDECRGTLYK YRPEEVDIDA KLSRLCEQDK VVHALEEKLQ QLHKEKYTLE
QALLSASQEI EMNADNPAAI QTVVLQRDDL QNGLLSTCRE LSRATAELER AWREYDKLEY
DVTVTRNQMQ EQLDRLGEVQ TESAGIQRAQ IQKELWRIQD VMEGLSKHKQ QRGTSETGMI
GSKPFSTVKY KNEGPDYRLY KSEPELTTVA EVDESNGEEK SEPASEIETS VKGSHFPVGV
VPPRTKSPTP ESSTIASYVT LRKTKKMMDS RTERPRSAVE QLCLAESTRP RMTVEEQMER
IRRHQQACLR EKKKGLNLIG ALDQSPLPSP SNLRDNPFRI TQARRKDDNS KELDTVIREN
DMKPNHDTPS TDTVQLKEAE PQNTDFSEEF KKTENVFSET LFTPEPNGVN SEEVMDKEGD
KKEMPEHVPY SPQEESQIPN HKPEGPPAED TKDNIHEQEE NVLSYELTPE ASRGNQTMAA
QSLPPSPDSS ASPVPSAQPQ LTEGSHFMCV
//
