ID W5TG39_9NOCA Unreviewed; 403 AA.
AC W5TG39;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Probable acetyl-CoA acetyltransferase {ECO:0000256|ARBA:ARBA00040529};
DE EC=2.3.1.9 {ECO:0000256|ARBA:ARBA00012705};
GN ORFNames=NONO_c33470 {ECO:0000313|EMBL:AHH18134.1};
OS Nocardia nova SH22a.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=1415166 {ECO:0000313|EMBL:AHH18134.1, ECO:0000313|Proteomes:UP000019150};
RN [1] {ECO:0000313|EMBL:AHH18134.1, ECO:0000313|Proteomes:UP000019150}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SH22a {ECO:0000313|EMBL:AHH18134.1};
RX PubMed=24747905;
RA Luo Q., Hiessl S., Poehlein A., Daniel R., Steinbuchel A.;
RT "Insights into the Microbial Degradation of Rubber and Gutta-Percha by
RT Analysis of the Complete Genome of Nocardia nova SH22a.";
RL Appl. Environ. Microbiol. 80:3895-3907(2014).
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
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DR EMBL; CP006850; AHH18134.1; -; Genomic_DNA.
DR RefSeq; WP_025349576.1; NZ_CP006850.1.
DR AlphaFoldDB; W5TG39; -.
DR STRING; 1415166.NONO_c33470; -.
DR KEGG; nno:NONO_c33470; -.
DR PATRIC; fig|1415166.3.peg.3435; -.
DR eggNOG; COG0183; Bacteria.
DR HOGENOM; CLU_031026_2_2_11; -.
DR OrthoDB; 4440515at2; -.
DR Proteomes; UP000019150; Chromosome.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR18919; ACETYL-COA C-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR18919:SF153; TRIFUNCTIONAL ENZYME SUBUNIT BETA, MITOCHONDRIAL; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557};
KW Reference proteome {ECO:0000313|Proteomes:UP000019150};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:AHH18134.1}.
FT DOMAIN 4..268
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 276..401
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 88
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 358
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 388
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 403 AA; 42251 MW; B296AC89CDE74155 CRC64;
MRDVVICEPV RTPIGRYGGV LAALTAAELG VVALRGLLER TGISPDLIED VILGNCNPNS
EAPALGRVVA LDAGLPVTVG GMQLDRRCGS GLQSVIQAVL QVGSGANEIV VAGGAESMSN
VPFYSTDIRW GAARTGVTMH DGLVRARETA GGKFHPVPGG MLETAENLRR EYDIPREEQD
RLALRSHRRA IAAIEDGAAA QQIVPTPVRT RRAEQIVDTD EHPRADTTLE SLAALTPVRA
AIDPESTVTA GNSSGQNDAA ALCLVTTRDT AADLGLTPLV RLRSWAVAGV DPALMGIGPV
PATAAALARA GLDLADIDLI ELNEAFAAQA LAVLREWKFG ESDLDRVNVH GSGISLGHPV
GATGTRMLAT LARELHRRDL RYGLETMCIG GGQGLAAVFE KVD
//
