ID W5TIS9_9NOCA Unreviewed; 567 AA.
AC W5TIS9;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Putative 3-ketosteroid-delta-1-dehydrogenase KstD {ECO:0000313|EMBL:AHH19255.1};
GN ORFNames=NONO_c44710 {ECO:0000313|EMBL:AHH19255.1};
OS Nocardia nova SH22a.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=1415166 {ECO:0000313|EMBL:AHH19255.1, ECO:0000313|Proteomes:UP000019150};
RN [1] {ECO:0000313|EMBL:AHH19255.1, ECO:0000313|Proteomes:UP000019150}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SH22a {ECO:0000313|EMBL:AHH19255.1};
RX PubMed=24747905;
RA Luo Q., Hiessl S., Poehlein A., Daniel R., Steinbuchel A.;
RT "Insights into the Microbial Degradation of Rubber and Gutta-Percha by
RT Analysis of the Complete Genome of Nocardia nova SH22a.";
RL Appl. Environ. Microbiol. 80:3895-3907(2014).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
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DR EMBL; CP006850; AHH19255.1; -; Genomic_DNA.
DR RefSeq; WP_025350661.1; NZ_CP006850.1.
DR AlphaFoldDB; W5TIS9; -.
DR STRING; 1415166.NONO_c44710; -.
DR KEGG; nno:NONO_c44710; -.
DR PATRIC; fig|1415166.3.peg.4593; -.
DR eggNOG; COG1053; Bacteria.
DR HOGENOM; CLU_011398_4_2_11; -.
DR OrthoDB; 9813348at2; -.
DR Proteomes; UP000019150; Chromosome.
DR GO; GO:0033765; F:steroid dehydrogenase activity, acting on the CH-CH group of donors; IEA:UniProt.
DR GO; GO:0008202; P:steroid metabolic process; IEA:UniProt.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR InterPro; IPR003953; FAD-binding_2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR027477; Succ_DH/fumarate_Rdtase_cat_sf.
DR PANTHER; PTHR43400:SF7; FAD_BINDING_2 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR43400; FUMARATE REDUCTASE; 1.
DR Pfam; PF00890; FAD_binding_2; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF56425; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
PE 4: Predicted;
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000019150}.
FT DOMAIN 16..547
FT /note="FAD-dependent oxidoreductase 2 FAD binding"
FT /evidence="ECO:0000259|Pfam:PF00890"
SQ SEQUENCE 567 AA; 59170 MW; 1F3D009326F2C5EA CRC64;
MNSTEDNTPV AQHEVDLLIV GSGTGLAAAL AATEAGLSTL VVEKSGYVGG STARSGGAFW
VPGNFVLADR QPADNAAAAS AYVEAVVGDS APPERGAAFL EHGPAAVEML ARTTPMTFMW
ADGYSDYHPE LPGGSAVGRT CECKPFDAAR LGTQRSRLRP GVMEASGLPM PVTGADYKWL
NLIAKTPRKA LWRGMKAMAT GVGGLALKRE YIAGGQALAA GLFAGAIRAG IPIWTDTALV
RLIESDGVVT GAVVDHEGTL TTVTARRGVV LAAGGFDHDT RMRRKFQSDK LVEHASLGCE
ANTGDAIELA QEVGAAIGLM DQAWWFPAVA ALPGAAPAVL LAERALPGSF IVDHTGQRFV
NEATDYMSFG QRVLERERAG DPVQDMWLVF DQRYRNSYIF AAGLFPRQPL PQAWYDNGIA
VTAADPAGLA RAMGVPAPAF ATTFDTFNTA AQLGVDHEFS RGASAYDRYY GDPTIAPNPN
LRPLGGKGSL YAVKLVLSDL GTCGGLRADG SARVLREDGS VIEGLYAIGN TAANAFGNTY
PGAGATIGQG LVFGYIAAKT AAALGRA
//
