ID W5U9P1_ICTPU Unreviewed; 1350 AA.
AC W5U9P1;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Sushi, nidogen and EGF-like domain-containing protein 1 {ECO:0000313|EMBL:AHH38678.1, ECO:0000313|RefSeq:XP_017335839.1};
GN Name=SNED1 {ECO:0000313|EMBL:AHH38678.1};
GN Synonyms=sned1 {ECO:0000313|RefSeq:XP_017335839.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|EMBL:AHH38678.1};
RN [1] {ECO:0000313|EMBL:AHH38678.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Mixed {ECO:0000313|EMBL:AHH38678.1};
RX PubMed=23127152; DOI=10.1186/1471-2164-13-595;
RA Liu S., Zhang Y., Zhou Z., Waldbieser G., Sun F., Lu J., Zhang J.,
RA Jiang Y., Zhang H., Wang X., Rajendran K.V., Khoo L., Kucuktas H.,
RA Peatman E., Liu Z.;
RT "Efficient assembly and annotation of the transcriptome of catfish by RNA-
RT Seq analysis of a doubled haploid homozygote.";
RL BMC Genomics 13:595-595(2012).
RN [2] {ECO:0000313|RefSeq:XP_017335839.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017335839.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; JT409439; AHH38678.1; -; mRNA.
DR RefSeq; XP_017335839.1; XM_017480350.3.
DR STRING; 7998.ENSIPUP00000021929; -.
DR Ensembl; ENSIPUT00000022732; ENSIPUP00000021794; ENSIPUG00000014673.
DR GeneID; 108272139; -.
DR KEGG; ipu:108272139; -.
DR CTD; 25992; -.
DR OMA; KAIRHRT; -.
DR OrthoDB; 5475408at2759; -.
DR Proteomes; UP000221080; Chromosome 11.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0007160; P:cell-matrix adhesion; IEA:InterPro.
DR CDD; cd00033; CCP; 1.
DR CDD; cd00054; EGF_CA; 11.
DR CDD; cd00063; FN3; 3.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 2.10.25.10; Laminin; 12.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003886; NIDO_dom.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR PANTHER; PTHR12916; CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2; 1.
DR PANTHER; PTHR12916:SF4; NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1-RELATED; 1.
DR Pfam; PF00008; EGF; 8.
DR Pfam; PF07974; EGF_2; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF12661; hEGF; 2.
DR Pfam; PF06119; NIDO; 1.
DR PRINTS; PR00010; EGFBLOOD.
DR SMART; SM00032; CCP; 1.
DR SMART; SM00181; EGF; 14.
DR SMART; SM00179; EGF_CA; 12.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00539; NIDO; 1.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 9.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS00022; EGF_1; 12.
DR PROSITE; PS01186; EGF_2; 7.
DR PROSITE; PS50026; EGF_3; 12.
DR PROSITE; PS01187; EGF_CA; 3.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS51220; NIDO; 1.
DR PROSITE; PS50923; SUSHI; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1350
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013540250"
FT DOMAIN 104..259
FT /note="NIDO"
FT /evidence="ECO:0000259|PROSITE:PS51220"
FT DOMAIN 269..310
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 312..348
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 350..386
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 388..424
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 470..505
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 555..591
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 594..630
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 633..669
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 681..738
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 738..774
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 776..812
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 814..851
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 856..951
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 952..1050
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1051..1145
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1249..1285
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 1149..1184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1156..1184
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 300..309
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 338..347
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 376..385
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 414..423
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 495..504
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 581..590
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 620..629
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 659..668
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 709..736
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 764..773
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 802..811
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 841..850
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1275..1284
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1350 AA; 148895 MW; E924544985DE1D79 CRC64;
MGRLRQLLLC LCTLLWLGIP IGVMPAVPLE DFYSFGQEQG DSQTITQDDG GSGLVEISVA
FPFFGDRHTG LYVNNNGLVS FLREVSQFTP VAFPIAGDRR VVAPFWADVD NRQAGIVFYR
ESKDPAILKR ATEDIHYYFP EFPTFTATWV LVATWHNVTF FGGSPATPVN TFQVVLITDG
ELSFTIFQYH NVTWTTGMHA SSGGDHSGLG GIAAQAGFNA GDGRRYFNIP GSRTDDVVEV
ETTTNVGYPG RWVFRIDDAQ VEVGSCNDSA SVCPHLRPCL NGGRCIDDCI TGNPSFTCSC
LAGFTGRTCQ IDIDECSSYP CQNGGTCTDG VNSFTCHCPP GFTGTLCETD IDECQENPCL
NGARCMEGEG SFTCQCHAGY TGSVCETDIN ECESNPCVNG GVCEDKVNNY TCTCTANFTG
SQCETELVIV TNSSSIEIAN QTASCEQDGC NICEYISSGN YNCTCKPGYY GDHCEEECLC
QNGGVCIDAN GTCECPTGFT GLYCQFEVTQ TPCSNSRPCP DGGPCLEYGG TYLCTCQTGI
DFEHDHRDFY PYVQPQSACD SSPCQNGGYC YEHEGGYTCE CEHGYKGENC EKVRLSMCAS
SPCRNGGSCK EETGSYYCVC PYRFTGKHCE VGKPDPCASG PCMNGGTCFH YIGKYKCECP
GSFMGRHCEI SKGASPALDG NDCGPPPKLK HAEVQYSSTS PGSLALYTCH PGYTPNPRST
QSICSSHGSW TQPPVCDEIN ECLSQPCMNG GTCRDRVASF LCECESGFTG QRCQTEQDGC
ESNPCQNGGV CRGYRRRHLC VCKEGYIGDR CQTLENPCVL QPCGNRGFCR SDRRGNYSCA
CRVGHTGRDC ERDLLPPSGL HVLRVEESEV ELRWDQADTN QNLISGFAIT YAPIGRSPRK
TDFLERQHST YVLQGLSPGQ LYNISTYSIK RNSNSNDISQ PATALIRTRP RKVDQLQVVN
VSSSQVWLQW LVQAGWHAAV NLVRVSLVPS DGSGTRTSVL NASVMEYSFS SLLPGQMYTV
DVLTQSGLRP EDLPSTSHSS GPLHFWTKPF PPQNLSLSHV SSSTARVTWD RHPRSIPDGF
VVNVTRGLTT RSRYLPDGTL SMYTIRELSP GQHYRLALTA VRNTGHEQIH SVAQHLAFTT
LTLEEPQGIA ERTQGGRDTS SRRTLTRTKV KHQGSDKDRE HSEELPRYTE LIDGRGRITA
KFTNSQRKVI RHRTKPEPPI KLERMEETTN KISLALEIPE EVTKIKSESQ RDCRTQPCQN
GGTCIQSGDI FSCECLTSFK GRQCELYCQR VKHPCTRLYS ETKSVPVWED GVCHYLYKRT
YKVQQDICFR EICEPVLNNK NPNRRTQRQQ
//
