ID W5UGA1_ICTPU Unreviewed; 581 AA.
AC W5UGA1; A0A2D0Q895;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Mucolipin-1 {ECO:0000313|EMBL:AHH38702.1, ECO:0000313|RefSeq:XP_017313585.2};
GN Name=Mcoln1 {ECO:0000313|EMBL:AHH38702.1};
GN Synonyms=mcoln1a {ECO:0000313|RefSeq:XP_017313585.2};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|EMBL:AHH38702.1};
RN [1] {ECO:0000313|EMBL:AHH38702.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Mixed {ECO:0000313|EMBL:AHH38702.1};
RX PubMed=23127152; DOI=10.1186/1471-2164-13-595;
RA Liu S., Zhang Y., Zhou Z., Waldbieser G., Sun F., Lu J., Zhang J.,
RA Jiang Y., Zhang H., Wang X., Rajendran K.V., Khoo L., Kucuktas H.,
RA Peatman E., Liu Z.;
RT "Efficient assembly and annotation of the transcriptome of catfish by RNA-
RT Seq analysis of a doubled haploid homozygote.";
RL BMC Genomics 13:595-595(2012).
RN [2] {ECO:0000313|RefSeq:XP_017313585.2}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017313585.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004337}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; JT409492; AHH38702.1; -; mRNA.
DR RefSeq; XP_017313585.1; XM_017458096.1.
DR RefSeq; XP_017313585.2; XM_017458096.3.
DR STRING; 7998.ENSIPUP00000031624; -.
DR Ensembl; ENSIPUT00000032857; ENSIPUP00000031596; ENSIPUG00000021228.
DR GeneID; 108258996; -.
DR KEGG; ipu:108258996; -.
DR CTD; 406689; -.
DR OrthoDB; 2877219at2759; -.
DR Proteomes; UP000221080; Chromosome 26.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR CDD; cd21070; ELD_TRPML1; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR049134; MCLN_ECD.
DR InterPro; IPR047316; ML1_ELD.
DR InterPro; IPR039031; Mucolipin.
DR InterPro; IPR013122; PKD1_2_channel.
DR PANTHER; PTHR12127; MUCOLIPIN; 1.
DR PANTHER; PTHR12127:SF6; MUCOLIPIN-1; 1.
DR Pfam; PF21381; MCLN_ECD; 1.
DR Pfam; PF08016; PKD_channel; 1.
PE 2: Evidence at transcript level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 303..325
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 358..377
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 389..409
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 429..451
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 497..518
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 106..289
FT /note="Mucolipin extracytosolic"
FT /evidence="ECO:0000259|Pfam:PF21381"
FT DOMAIN 389..525
FT /note="Polycystin cation channel PKD1/PKD2"
FT /evidence="ECO:0000259|Pfam:PF08016"
SQ SEQUENCE 581 AA; 66028 MW; 4811D74B6A434928 CRC64;
MALVDQNNAV HDSTEKDRLL SPVNCYGSHD HCIDHNNSRL YPATGIWVTM DQEEEALRRK
MKYFFMSPCD KYHAKGRKPF KLVLQILKIF IVTVQLVLFG LSNQMVVTFK EENTASFKHL
FLKDYVDGAD DTLAVYTQSD VYEQIYYAIE QYLILPDTTV GRYAYVYGVG VNGSALSLCQ
QYYKKGRIDP ANDTFSIDPH IITDCVGVSP LSIPDGFVKN EFKNFTLKFH KLINVTIQFQ
LKAINLQTII NNEIPDCYTF VITIVLDNKA HSGKVKISLE NQVSIKECRD PSVSGHAESY
TRVAFDVVVA IMCGLSLVLC GRSIFRGILL QHEFVQYFKN KLKRSVCWGD RMEFINGWYI
LLIISDLLTI AGSFIKIGIE SKNISSYDVC GILLGTSTLL VWVGVIRYLS FFQKYNILIV
TLRAAFPNVI RFCCCVAVIY LGYCFCGWIV LGPYHVKFRS LSMVSECLFS LINGDDMFVT
FSGMQESSTL VWVFSQVYLY TFIALFIYMV LSLFIALITG AYETIKHQTQ EPIHITDLHA
FIAECKDTPS SGKFRGLETS PCSFFCCCDR TTTYEDVLLV N
//
