ID W5UGG2_9ENTR Unreviewed; 292 AA.
AC W5UGG2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=Aminoglycoside (3'') (9) adenylyltransferase {ECO:0000256|ARBA:ARBA00035252};
DE EC=2.7.7.47 {ECO:0000256|ARBA:ARBA00035126};
DE Flags: Fragment;
OS uncultured Salmonella sp.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella; environmental samples.
OX NCBI_TaxID=263771 {ECO:0000313|EMBL:AHH40990.1};
RN [1] {ECO:0000313|EMBL:AHH40990.1}
RP NUCLEOTIDE SEQUENCE.
RA Li M.;
RT "Occurrence of microbial antibiotic resistance in the water environment in
RT association with swine wastewater.";
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + spectinomycin = 9-O-adenylylspectinomycin + diphosphate;
CC Xref=Rhea:RHEA:63228, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:146260, ChEBI:CHEBI:146261;
CC Evidence={ECO:0000256|ARBA:ARBA00001672};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + streptomycin = 3''-O-adenylylstreptomycin + diphosphate;
CC Xref=Rhea:RHEA:20245, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:58007, ChEBI:CHEBI:58605; EC=2.7.7.47;
CC Evidence={ECO:0000256|ARBA:ARBA00035070};
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DR EMBL; KF849268; AHH40990.1; -; Genomic_DNA.
DR AlphaFoldDB; W5UGG2; -.
DR GO; GO:0070566; F:adenylyltransferase activity; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR CDD; cd05403; NT_KNTase_like; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR InterPro; IPR024172; AadA/Aad9.
DR InterPro; IPR025184; AadA_C.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR002934; Polymerase_NTP_transf_dom.
DR Pfam; PF13427; AadA_C; 1.
DR Pfam; PF01909; NTP_transf_2; 1.
DR PIRSF; PIRSF000819; Streptomycin_3-adenylyltransf; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251}.
FT DOMAIN 57..104
FT /note="Polymerase nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF01909"
FT DOMAIN 181..283
FT /note="Adenylyltransferase AadA C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13427"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AHH40990.1"
SQ SEQUENCE 292 AA; 32577 MW; 9C70E10670D0D7B4 CRC64;
RYAVGRCLML WSSNDVTQQG SRPKTKLNIM REAVIAEVST QLSEVVGVIE RHLEPTLLAV
HLYGSAVDGG LKPHSDIDLL VTVTVRLDET TRRALINDLL ETSASPGESE ILRAVEVTIV
VHDDIIPWRY PAKRELQFGE WQRNDILAGI FEPATIDIDL AILLTKAREH SVALVGPAAE
ELFDPVPEQD LFEALNETLT LWNSPPDWAG DERNVVLTLS RIWYGAVTGK IAPKDVAADW
AMERPPAQYQ PVILEARQAY LGQEEDRLGS RADQLEEFVH YVKGEITKVV GK
//
