ID W6A2J7_CHIKV Unreviewed; 1248 AA.
AC W6A2J7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 22-FEB-2023, entry version 43.
DE RecName: Full=Structural polyprotein {ECO:0000256|ARBA:ARBA00014555};
DE AltName: Full=p130 {ECO:0000256|ARBA:ARBA00033029};
GN Name=gp2 {ECO:0000313|EMBL:AIZ47355.1};
OS Chikungunya virus (CHIKV).
OC Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
OC Martellivirales; Togaviridae; Alphavirus.
OX NCBI_TaxID=37124 {ECO:0000313|EMBL:AHI50299.1, ECO:0000313|Proteomes:UP000171412};
OH NCBI_TaxID=7159; Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OH NCBI_TaxID=7160; Aedes albopictus (Asian tiger mosquito) (Stegomyia albopicta).
OH NCBI_TaxID=299627; Aedes furcifer (Mosquito).
OH NCBI_TaxID=188700; Aedes polynesiensis (Polynesian tiger mosquito).
OH NCBI_TaxID=9533; Cercopithecus.
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9539; Macaca (macaques).
OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
OH NCBI_TaxID=9554; Papio (baboons).
OH NCBI_TaxID=9573; Presbytis.
RN [1] {ECO:0000313|EMBL:AHI50299.1, ECO:0000313|Proteomes:UP000171412}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LEIV-CHIKV/Moscow/1/2013 {ECO:0000313|EMBL:AHI50299.1};
RA Shchelkanov M.Y., Lvov D.K., Alkhovsky S.V., Shchetinin A.M.;
RT "Isolation of Chikungunya virus from the blood of a tourist who came from
RT Indonesia. Moscow, Russia, 2013.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AIZ47355.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DH130003 {ECO:0000313|EMBL:AIZ47355.1};
RA Woelfel S., Vollmar P., Poluda D., Zange S., Antwerpen M.H., Loescher T.,
RA Dobler G.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AIZ47355.1, ECO:0000313|Proteomes:UP000151115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DH130003 {ECO:0000313|EMBL:AIZ47355.1};
RX PubMed=25814598;
RA Wolfel S., Vollmar P., Poluda D., Zange S., Antwerpen M.H., Loscher T.,
RA Dobler G.;
RT "Complete genome sequence of a chikungunya virus imported from bali to
RT Germany.";
RL Genome Announc. 3:0-0(2015).
RN [4] {ECO:0000313|EMBL:ANY27000.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=1207aTw {ECO:0000313|EMBL:ANY27000.1}, 1303aTw
RC {ECO:0000313|EMBL:ANY27003.1}, 1307aTw {ECO:0000313|EMBL:ANY27005.1},
RC 1308bTw {ECO:0000313|EMBL:ANY27006.1}, 1312cTw
RC {ECO:0000313|EMBL:ANY27009.1}, 1403bTw {ECO:0000313|EMBL:ANY27011.1},
RC 1404aTw {ECO:0000313|EMBL:ANY27012.1}, and 1408aTw
RC {ECO:0000313|EMBL:ANY27014.1};
RX PubMed=27767908; DOI=10.3201/eid2211.160404;
RA Yang C.F., Su C.L., Hsu T.C., Chang S.F., Lin C.C., Huang J.C., Shu P.Y.;
RT "Imported Chikungunya Virus Strains, Taiwan, 2006-2014.";
RL Emerg. Infect. Dis. 22:1981-1984(2016).
RN [5] {ECO:0000313|EMBL:ANY27000.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=1207aTw {ECO:0000313|EMBL:ANY27000.1}, 1303aTw
RC {ECO:0000313|EMBL:ANY27003.1}, 1307aTw {ECO:0000313|EMBL:ANY27005.1},
RC 1308bTw {ECO:0000313|EMBL:ANY27006.1}, 1312cTw
RC {ECO:0000313|EMBL:ANY27009.1}, 1403bTw {ECO:0000313|EMBL:ANY27011.1},
RC 1404aTw {ECO:0000313|EMBL:ANY27012.1}, and 1408aTw
RC {ECO:0000313|EMBL:ANY27014.1};
RA Oliw E.H.;
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:BBC18124.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CHIKV/Hu/Indonesia/NIID181/2012 {ECO:0000313|EMBL:BBC18124.1};
RA Nakayama E., Tajima S., Kotaki A., Tomohiko T.;
RT "A summary of the imported cases of Chikungunya fever in Japan from 2006 to
RT June 2016.";
RL J Travel Med 25 0:tax072-tax072(2018).
RN [7] {ECO:0000313|EMBL:QPF47967.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=201610127 {ECO:0000313|EMBL:QPF47967.1}, 201610133
RC {ECO:0000313|EMBL:QPF47969.1}, 201610136
RC {ECO:0000313|EMBL:QPF47971.1}, and JMB-172
RC {ECO:0000313|EMBL:QPF47979.1};
RX PubMed=33347450;
RA Stubbs S.C.B., Johar E., Yudhaputri F.A., Yohan B., Santoso M.S.,
RA Hayati R.F., Denis D., Blacklaws B.A., Powers A.M., Sasmono R.T.,
RA Myint K.S.A., Frost S.D.W.;
RT "An investig-ation into the epidemiology of chikungunya virus across
RT neglected regions of Indonesia.";
RL PLoS Negl. Trop. Dis. 14:0-0(0).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Autocatalytic release of the core protein from the N-terminus
CC of the togavirus structural polyprotein by hydrolysis of a -Trp-|-
CC Ser- bond.; EC=3.4.21.90; Evidence={ECO:0000256|ARBA:ARBA00000840};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Cytoplasm
CC {ECO:0000256|ARBA:ARBA00004496}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004598}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004598}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Host cytoplasm
CC {ECO:0000256|ARBA:ARBA00004192}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004385}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004385}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
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DR EMBL; KF872195; AHI50299.1; -; Genomic_RNA.
DR EMBL; KM673291; AIZ47355.1; -; Genomic_RNA.
DR EMBL; KU561444; ANY27000.1; -; Genomic_RNA.
DR EMBL; KU561447; ANY27003.1; -; Genomic_RNA.
DR EMBL; KU561449; ANY27005.1; -; Genomic_RNA.
DR EMBL; KU561450; ANY27006.1; -; Genomic_RNA.
DR EMBL; KU561453; ANY27009.1; -; Genomic_RNA.
DR EMBL; KU561455; ANY27011.1; -; Genomic_RNA.
DR EMBL; KU561456; ANY27012.1; -; Genomic_RNA.
DR EMBL; KU561458; ANY27014.1; -; Genomic_RNA.
DR EMBL; LC259085; BBC18124.1; -; Genomic_RNA.
DR EMBL; MT591086; QPF47967.1; -; Genomic_RNA.
DR EMBL; MT591087; QPF47969.1; -; Genomic_RNA.
DR EMBL; MT591088; QPF47971.1; -; Genomic_RNA.
DR EMBL; MT591092; QPF47979.1; -; Genomic_RNA.
DR Proteomes; UP000151115; Genome.
DR Proteomes; UP000171412; Genome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0039619; C:T=4 icosahedral viral capsid; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0039654; P:fusion of virus membrane with host endosome membrane; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR Gene3D; 1.10.287.2230; -; 1.
DR Gene3D; 2.60.40.350; -; 1.
DR Gene3D; 2.60.40.3200; Alphavirus E2 glycoprotein, A domain; 1.
DR Gene3D; 2.60.40.4310; Alphavirus E2 glycoprotein, domain B; 1.
DR Gene3D; 2.60.40.2400; Alphavirus E2 glycoprotein, domain C; 1.
DR Gene3D; 2.60.98.10; Tick-borne Encephalitis virus Glycoprotein, domain 1; 3.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR InterPro; IPR002548; Alpha_E1_glycop.
DR InterPro; IPR000936; Alpha_E2_glycop.
DR InterPro; IPR002533; Alpha_E3_glycop.
DR InterPro; IPR042304; Alphavir_E2_A.
DR InterPro; IPR042305; Alphavir_E2_B.
DR InterPro; IPR042306; Alphavir_E2_C.
DR InterPro; IPR000336; Flavivir/Alphavir_Ig-like_sf.
DR InterPro; IPR036253; Glycoprot_cen/dimer_sf.
DR InterPro; IPR038055; Glycoprot_E_dimer_dom.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR000930; Peptidase_S3.
DR Pfam; PF01589; Alpha_E1_glycop; 1.
DR Pfam; PF00943; Alpha_E2_glycop; 1.
DR Pfam; PF01563; Alpha_E3_glycop; 1.
DR Pfam; PF00944; Peptidase_S3; 1.
DR PRINTS; PR00798; TOGAVIRIN.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR SUPFAM; SSF56983; Viral glycoprotein, central and dimerisation domains; 1.
DR PROSITE; PS51690; ALPHAVIRUS_CP; 1.
PE 4: Predicted;
KW Capsid protein {ECO:0000256|ARBA:ARBA00022561};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Fusion of virus membrane with host endosomal membrane
KW {ECO:0000256|ARBA:ARBA00022510};
KW Fusion of virus membrane with host membrane
KW {ECO:0000256|ARBA:ARBA00022506};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host cytoplasm {ECO:0000256|ARBA:ARBA00023200};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825};
KW T=4 icosahedral capsid protein {ECO:0000256|ARBA:ARBA00022973};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804};
KW Viral penetration into host cytoplasm {ECO:0000256|ARBA:ARBA00022595};
KW Virion {ECO:0000256|ARBA:ARBA00022844};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT TRANSMEM 687..715
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 766..787
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1226..1246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 113..261
FT /note="Peptidase S3"
FT /evidence="ECO:0000259|PROSITE:PS51690"
FT REGION 1..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..73
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..102
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 139
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR600936-1"
FT ACT_SITE 161
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR600936-1"
FT ACT_SITE 213
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR600936-1"
SQ SEQUENCE 1248 AA; 138432 MW; 52B8BB74DD75FAD2 CRC64;
MEFIPTQTFY NRRYQPRPWT PRPTIQVIRP RPRPQRKAGQ LAQLISAVNK LTMRVVPQQK
PRKNRKNKKQ KQKQQAPRNN MNQKKQPPKK KPVQKKKKPG RRERMCMKIE NDCIFEVKHE
GKVTGYACLV GDKVMKPAHV KGTIDNADLA KLAFKRSSKY DLECAQIPVH MKSDASKFTH
EKPEGYYNWH HGAVQYSGGR FTIPTGAGKP GDSGRPIFDN KGRVVAIVLG GANEGARTAL
SVVTWNKDIV TKITPEGAEE WSLAIPVMCL LANTTFPCSQ PPCTPCCYEK EPEKTLRMLE
DNVMSPGYYQ LLQASLTCSP RRQRRSIKDH FNVYKATRPY LAHCPDCGEG HSCHSPVALE
RIRNEATDGT LKIQVSLQIG IKTDDSHDWT KLRYMDNHMP ADAERAGLFV RTSAPCTITG
TMGHFILARC PKGETLTVGF TDGRKISHSC THPFHHDPPV IGREKFHSRP QHGRELPCST
YAQSTAATAE EIEVHMPPDT PDRTLMSQQS GNVKITVNSQ TVRYKCNCGD SSEGLTTTDK
VINNCKVDQC HAAVTNHKKW QYNSPLVPRN AESGDRKGKV HIPFPLANVT CRVPKARNPT
VTYGKNQVIM LLYPDHPTLL SYRNMGEEPN YREEWVTHKK EIRLTVPTEG LEVTWGNNEP
YKYWPQLSTN GTAHGHPHEI ILYYYELYPT MTVVVVSVAS FILLSMVGVA VGMCMCARRR
CITPYELTPG ATVPFLLSLI CCIRTAKAAT YQEAAVYLWN EQQPLFWLQA LIPLAALIVL
CNCLRLLPCC CKMLTFLAVL SVGAHTVSAY EHVTVIPNTV GVPYKTLVNR PGYSPMVLEM
ELLSVTLEPT LSLDYITCEY KTVIPSPYVK CCGTAECKDK SLPDYSCKVF TGVYPFMWGG
AYCFCDTENT QLSEAHVEKS ESCKTEFASA YRAHTASASA KLRVLYQGNN ITVAAYANGD
HAVTVKDAKF IVGPMSSAWT PFDNKIVVYK GDVYNMDYPP FGAGRPGQFG DIQSRTPESE
DVYANTQLVL QRPSAGTVHV PYSQAPSGFK YWLKERGASL QHTAPFGCQI ATNPVRAMNC
AVGNMPISID IPDAAFTRVV DAPSLTDMSC EVSACTHSSD FGGVAIIKYT ASKKGKCAVH
SMTNAVTIRE AEIEVEGNSQ LQISFSTALA SAEFRVQVCS TQVHCAAECH PPKDHIVNYP
ASHTTPGVQD ISATAMSWVQ KITGGVGLVV AVAALILIVV LCVSFSRH
//
