ID W6AUW7_KLEPN Unreviewed; 185 AA.
AC W6AUW7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Mobile element protein {ECO:0000313|EMBL:QIM11227.1};
DE SubName: Full=Recombinase family protein {ECO:0000313|EMBL:QOS10038.1};
DE SubName: Full=Resolvase {ECO:0000313|EMBL:AHH27803.1};
DE SubName: Full=TnR of Tn3 {ECO:0000313|EMBL:AHI61882.1};
GN Name=tnpR {ECO:0000313|EMBL:AHI61882.1};
GN ORFNames=GLO21_027825 {ECO:0000313|EMBL:QOS10038.1}, GLO21_028380
GN {ECO:0000313|EMBL:QOS10143.1};
OS Klebsiella pneumoniae subsp. pneumoniae.
OG Plasmid pColE-1825 {ECO:0000313|EMBL:QOS10143.1,
OG ECO:0000313|Proteomes:UP000437398},
OG Plasmid pHS092839 {ECO:0000313|EMBL:AHH27803.1},
OG Plasmid pHS10505 {ECO:0000313|EMBL:AHI61882.1},
OG Plasmid pIT-1825-FIIK1 {ECO:0000313|EMBL:QOS10038.1,
OG ECO:0000313|Proteomes:UP000437398},
OG Plasmid pKPC2_sg1 {ECO:0000313|EMBL:QIM11227.1}, and
OG Plasmid pKPC2_sg2 {ECO:0000313|EMBL:QIM11331.1}.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX NCBI_TaxID=72407 {ECO:0000313|EMBL:AHI61882.1};
RN [1] {ECO:0000313|EMBL:AHI61882.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HS10505 {ECO:0000313|EMBL:AHI61882.1};
RC PLASMID=pHS10505 {ECO:0000313|EMBL:AHI61882.1};
RA Zhang Y., Li G., Jiang X.;
RT "Evidence showing Tn3 was inserted in Tn1721 during the dissemination of
RT blaKPC-2 around clinical Enterobacteriaceae isolates.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AHH27803.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HS092839 {ECO:0000313|EMBL:AHH27803.1};
RC PLASMID=pHS092839 {ECO:0000313|EMBL:AHH27803.1};
RX PubMed=25367902; DOI=10.1128/AAC.03061-14;
RA Li G., Zhang Y., Bi D., Shen P., Ai F., Liu H., Tian Y., Ma Y., Wang B.,
RA Rajakumar K., Ou H.Y., Jiang X.;
RT "First Report of a Clinical, Multidrug-Resistant Enterobacteriaceae Isolate
RT Coharboring Fosfomycin Resistance Gene fosA3 and Carbapenemase Gene blaKPC-
RT 2 on the Same Transposon, Tn1721.";
RL Antimicrob. Agents Chemother. 59:338-343(2015).
RN [3] {ECO:0000313|EMBL:QIM11227.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=494 {ECO:0000313|EMBL:QIM11227.1}, and 607
RC {ECO:0000313|EMBL:QIM11331.1};
RC PLASMID=pKPC2_sg1 {ECO:0000313|EMBL:QIM11227.1}, and pKPC2_sg2
RC {ECO:0000313|EMBL:QIM11331.1};
RA Chen Y., Marimuthu K., Ng O.T., Gan Y.-H.;
RT "Emergence of carbapenem-resistant hypervirulent Klebsiella pneumoniae
RT carrying blaKPC-2 gene in Singapore.";
RL Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:QOS10038.1, ECO:0000313|Proteomes:UP000437398}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LC-1825/18 {ECO:0000313|EMBL:QOS10038.1,
RC ECO:0000313|Proteomes:UP000437398};
RC PLASMID=pColE-1825 {ECO:0000313|EMBL:QOS10143.1,
RC ECO:0000313|Proteomes:UP000437398}, and pIT-1825-FIIK1
RC {ECO:0000313|EMBL:QOS10038.1, ECO:0000313|Proteomes:UP000437398};
RA Di Pilato V., Aiezza N., Viaggi V., Antonelli A., Principe L., Giani T.,
RA Luzzaro F., Rossolini G.M.;
RT "KPC-53, a KPC-3 variant of clinical origin associated with reduced
RT susceptibility to ceftazidime-avibactam.";
RL Antimicrob. Agents Chemother. 65:0-0(2020).
CC -!- SIMILARITY: Belongs to the site-specific recombinase resolvase family.
CC {ECO:0000256|ARBA:ARBA00009913}.
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DR EMBL; KF724506; AHH27803.1; -; Genomic_DNA.
DR EMBL; KF826292; AHI61882.1; -; Genomic_DNA.
DR EMBL; MN542377; QIM11227.1; -; Genomic_DNA.
DR EMBL; MN542378; QIM11331.1; -; Genomic_DNA.
DR EMBL; CP058327; QOS10038.1; -; Genomic_DNA.
DR EMBL; CP058329; QOS10143.1; -; Genomic_DNA.
DR RefSeq; WP_001217881.1; NZ_VRSA01000005.1.
DR AlphaFoldDB; W6AUW7; -.
DR SMR; W6AUW7; -.
DR KEGG; kpg:KPNIH32_24365; -.
DR KEGG; kpg:KPNIH32_27920; -.
DR KEGG; kpg:KPNIH32_29455; -.
DR KEGG; kpv:KPNIH29_26620; -.
DR KEGG; kpw:KPNIH30_26815; -.
DR KEGG; kpy:KPNIH31_06355; -.
DR KEGG; kpy:KPNIH31_25935; -.
DR PATRIC; fig|72407.105.peg.446; -.
DR OMA; EQIRFAY; -.
DR Proteomes; UP000437398; Plasmid pColE-1825.
DR Proteomes; UP000437398; Plasmid pIT-1825-FIIK1.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000150; F:DNA strand exchange activity; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR CDD; cd03768; SR_ResInv; 1.
DR Gene3D; 6.10.250.10; -; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 3.40.50.1390; Resolvase, N-terminal catalytic domain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR006118; Recombinase_CS.
DR InterPro; IPR006119; Resolv_N.
DR InterPro; IPR036162; Resolvase-like_N_sf.
DR InterPro; IPR006120; Resolvase_HTH_dom.
DR PANTHER; PTHR30461; DNA-INVERTASE FROM LAMBDOID PROPHAGE; 1.
DR PANTHER; PTHR30461:SF22; SERINE RECOMBINASE PINE-RELATED; 1.
DR Pfam; PF02796; HTH_7; 1.
DR Pfam; PF00239; Resolvase; 1.
DR SMART; SM00857; Resolvase; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF53041; Resolvase-like; 1.
DR PROSITE; PS00397; RECOMBINASES_1; 1.
DR PROSITE; PS00398; RECOMBINASES_2; 1.
DR PROSITE; PS51736; RECOMBINASES_3; 1.
PE 3: Inferred from homology;
KW DNA integration {ECO:0000256|ARBA:ARBA00022908};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Plasmid {ECO:0000313|EMBL:AHI61882.1}.
FT DOMAIN 2..137
FT /note="Resolvase/invertase-type recombinase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS51736"
FT ACT_SITE 10
FT /note="O-(5'-phospho-DNA)-serine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR606118-50,
FT ECO:0000256|PROSITE-ProRule:PRU10137"
SQ SEQUENCE 185 AA; 20618 MW; A160E3DBFAF59C00 CRC64;
MRIFGYARVS TSQQSLDIQI RALKDAGVKA NRIFTDKASG SSTDREGLDL LRMKVEEGDV
ILVKKLDRLG RDTADMIQLI KEFDAQGVAV RFIDDGISTD GDMGQMVVTI LSAVAQAERR
RILERTNEGR QEAKLKGIKF GRRRTVDRNV VLTLHQKGTG ATEIAHQLSI ARSTVYKILE
DERAS
//
