ID W6JHY5_BOMMO Unreviewed; 426 AA.
AC W6JHY5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Homothorax {ECO:0000313|EMBL:BAO48186.1};
GN Name=Hth {ECO:0000313|EMBL:BAO48186.1};
GN Synonyms=101737806 {ECO:0000313|EnsemblMetazoa:NP_001296493.1};
OS Bombyx mori (Silk moth).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC Bombycidae; Bombycinae; Bombyx.
OX NCBI_TaxID=7091 {ECO:0000313|EMBL:BAO48186.1};
RN [1] {ECO:0000313|Proteomes:UP000005204}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=p50T {ECO:0000313|Proteomes:UP000005204};
RX PubMed=19121390; DOI=10.1016/j.ibmb.2008.11.004;
RG International Silkworm Genome Consortium;
RT "The genome of a lepidopteran model insect, the silkworm Bombyx mori.";
RL Insect Biochem. Mol. Biol. 38:1036-1045(2008).
RN [2] {ECO:0000313|EMBL:BAO48186.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24333180;
RA Kimoto M., Tsubota T., Uchino K., Sezutsu H., Takiya S.;
RT "Hox transcription factor Antp regulates sericin-1 gene expression in the
RT terminal differentiated silk gland of Bombyx mori.";
RL Dev. Biol. 386:64-71(2014).
RN [3] {ECO:0000313|EnsemblMetazoa:NP_001296493.1}
RP IDENTIFICATION.
RC STRAIN=p50T (Dazao) {ECO:0000313|EnsemblMetazoa:NP_001296493.1};
RG EnsemblMetazoa;
RL Submitted (JUN-2022) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the TALE/MEIS homeobox family.
CC {ECO:0000256|ARBA:ARBA00009661}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB841083; BAO48186.1; -; mRNA.
DR RefSeq; NP_001296493.1; NM_001309564.1.
DR RefSeq; XP_004923406.2; XM_004923349.2.
DR AlphaFoldDB; W6JHY5; -.
DR SMR; W6JHY5; -.
DR EnsemblMetazoa; NM_001309564.1; NP_001296493.1; LOC101737806.
DR GeneID; 101737806; -.
DR KEGG; bmor:101737806; -.
DR OrthoDB; 3180467at2759; -.
DR Proteomes; UP000005204; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IEA:UniProt.
DR GO; GO:0048646; P:anatomical structure formation involved in morphogenesis; IEA:UniProt.
DR GO; GO:0001654; P:eye development; IEA:UniProt.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:UniProt.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR InterPro; IPR032453; PKNOX/Meis_N.
DR PANTHER; PTHR11850:SF102; HOMEOBOX PROTEIN HOMOTHORAX; 1.
DR PANTHER; PTHR11850; HOMEOBOX PROTEIN TRANSCRIPTION FACTORS; 1.
DR Pfam; PF05920; Homeobox_KN; 1.
DR Pfam; PF16493; Meis_PKNOX_N; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000005204}.
FT DOMAIN 303..366
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 305..367
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 176..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 274..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 191..213
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 426 AA; 46913 MW; F17E2F11F118E78E CRC64;
MAQPRYDESL HGGGYMEGGA MYHEHRLTHP HLAPVHYPPP AAPAHALPGE PLVHKRDKDA
IYGHPLFPLL ALIFEKCELA TCTPRDPGVA GGDVCSSESF NEDIAVFSKQ IRQEKPYYIA
DPEVDSLMVQ AIQVLRFHLL ELEKVHELCD NFCHRYISCL KGKMPIDLVI DERETARPPD
ANGEPRSAPD SSHDGASTPD VRPPSSSLSY GGAVNDDVRS PGSGGTPGPL SQPPPQTLDA
TDPDAMGKWC PSRREWSSPP DVARRVYSSV FLGSPGEYPG DASNASIGSG EGTGEEDDDT
NGKKNQKKRG IFPKVATNIL RAWLFQHLTH PYPSEDQKKQ LAQDTGLTIL QVNNWFINAR
RRIVQPMIDQ SNRAVFPHAG PSGAYSPEAT MGYMMDGQQM MHRPPTDPAF HQGYAHYPAE
YYGHHL
//
