ID W6JJH3_9MYRI Unreviewed; 1022 AA.
AC W6JJH3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
DE Flags: Fragment;
GN Name=DPD1 {ECO:0000313|EMBL:BAO48686.1};
OS Thereuonema tuberculata.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC Notostigmophora; Scutigeromorpha; Scutigeridae; Thereuonema.
OX NCBI_TaxID=353554 {ECO:0000313|EMBL:BAO48686.1};
RN [1] {ECO:0000313|EMBL:BAO48686.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Th1 {ECO:0000313|EMBL:BAO48686.1};
RX PubMed=24535281; DOI=10.1038/srep04127;
RA Miyazawa H., Ueda C., Yahata K., Su Z.-H.;
RT "Molecular phylogeny of Myriapoda provides insights into evolutionary
RT patterns of the mode in post-embryonic development.";
RL Sci. Rep. 4:4127-4127(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632,
CC ECO:0000256|RuleBase:RU000442};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966,
CC ECO:0000256|RuleBase:RU000442};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755, ECO:0000256|RuleBase:RU000442}.
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DR EMBL; AB831769; BAO48686.1; -; mRNA.
DR AlphaFoldDB; W6JJH3; -.
DR GO; GO:0043625; C:delta DNA polymerase complex; IEA:UniProt.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd05777; DNA_polB_delta_exo; 1.
DR CDD; cd05533; POLBc_delta; 1.
DR Gene3D; 2.40.50.730; -; 2.
DR Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR042087; DNA_pol_B_thumb.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR025687; Znf-C4pol.
DR NCBIfam; TIGR00592; pol2; 1.
DR PANTHER; PTHR10322; DNA POLYMERASE CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR10322:SF23; DNA POLYMERASE DELTA CATALYTIC SUBUNIT; 1.
DR Pfam; PF00136; DNA_pol_B; 1.
DR Pfam; PF03104; DNA_pol_B_exo1; 1.
DR Pfam; PF14260; zf-C4pol; 1.
DR PRINTS; PR00106; DNAPOLB.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE 2: Evidence at transcript level;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485, ECO:0000256|RuleBase:RU000442};
KW DNA replication {ECO:0000256|RuleBase:RU000442};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU000442};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW ECO:0000256|RuleBase:RU000442};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU000442};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014, ECO:0000256|RuleBase:RU000442};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000442}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU000442};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU000442};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000442};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU000442};
KW Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT DOMAIN 91..397
FT /note="DNA-directed DNA polymerase family B exonuclease"
FT /evidence="ECO:0000259|Pfam:PF03104"
FT DOMAIN 461..890
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
FT DOMAIN 929..1000
FT /note="C4-type zinc-finger of DNA polymerase delta"
FT /evidence="ECO:0000259|Pfam:PF14260"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:BAO48686.1"
SQ SEQUENCE 1022 AA; 116487 MW; EE84BB115988653D CRC64;
VPTINSKTDT LEFQQIEIDY YVGKPLQGMP GNQSASVVPI MRMYGVTMNG NSVMCHVHGF
APYFFVPAPP GFTDNHCRGF KDALNKTVLN DMRSNKDNIT ETVLAVEITL KENMYGYHGN
RKVPFLKVTM ALPRLIAPAR RLLNDGINIP GLGQHAMASF ESNIDYEIRF MVDTNVVGCC
WIKLPAGKYR IRQSNSGPPL MSRCQLEVDV AWDEFIAHSP EGEWSKLAPF RILSFDIECA
GRKGIFPEPD KDPVIQIANM VVRQGDPTHF IRNVFTLKSC ASIVGAQVLS YDKESELLEK
WSDFIREVDP DIITGYNIQN FDLYYLLSRA NHLKVPKFPY LGRVKDIRTI IKTQMLQSKQ
MGRRENKNIN IEGRTQFDLL LILLRDYKLR SYTLNAVSFH FLQEQKEDVQ HSIITDLQNG
NEQTRRRLAV YCLKDAYLPL RLLDKLMCLF NYIEMARVTG VPLSYLLTRG QQIKVISQLL
RKSKEHDFVI PTVKAEVGED YTGATVIEPS VGYYNEPIAT LDFASLYPSI MIAHNLCYTT
VLKKQSDREN LNPEDFIKTP SNDYFMKSHV RRGLLPEIVE NLLAARKKAK ADLKNETDPL
RRKVLDGRQL ALKISANSVY GFTGAQVGKL PCLEISQSVT AFGRCMIEKT KSTVEAKYTK
ANGYKQNAQV IYGDTDSVMV KFGVETVADA MELGREAAEY VTQEFVKPIR LEFEKVYFPY
LLINKKRYAG LYFTRPETYD KMDCKGIETV RRDNCPLVAN LMNTCLQKIL IERDPDGAVE
YAKQIISDLL CNRIDISQLV ITKELTKTDD EYKGKQAHVE LSHRMRKRDA GSAPNLGDRV
PFVIIKAAKG TAAYMKSEDP IYVLENNIPI DTEYYLENQL SKPLLRIFNP VLKEKAESVL
LKGDHTRTKI VVTSKVGALS AFTKKRAACI GCKAVLENND AAVCKHCKVK ESEIFQREVA
QLGVLEEKFS RLWTQCQRCQ ESLHEDILCT SRDCPIFYMR KKVQKDLSDQ DKLMRRFGNL
DW
//
