ID   W6KM48_9TRYP            Unreviewed;       742 AA.
AC   W6KM48;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   RecName: Full=Cullin family profile domain-containing protein {ECO:0000259|PROSITE:PS50069};
GN   ORFNames=GSEM1_T00008290001 {ECO:0000313|EMBL:CCW62664.1};
OS   Phytomonas sp. EM1.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Phytomonas.
OX   NCBI_TaxID=479712 {ECO:0000313|EMBL:CCW62664.1, ECO:0000313|Proteomes:UP000027080};
RN   [1] {ECO:0000313|EMBL:CCW62664.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=EM1 {ECO:0000313|EMBL:CCW62664.1};
RA   Genoscope - CEA;
RL   Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CCW62664.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EM1 {ECO:0000313|EMBL:CCW62664.1};
RX   PubMed=24516393; DOI=10.1371/journal.pgen.1004007;
RA   Porcel B.M., Denoeud F., Opperdoes F., Noel B., Madoui M.A.,
RA   Hammarton T.C., Field M.C., Da Silva C., Couloux A., Poulain J.,
RA   Katinka M., Jabbari K., Aury J.M., Campbell D.A., Cintron R., Dickens N.J.,
RA   Docampo R., Sturm N.R., Koumandou V.L., Fabre S., Flegontov P., Lukes J.,
RA   Michaeli S., Mottram J.C., Szoor B., Zilberstein D., Bringaud F.,
RA   Wincker P., Dollet M.;
RT   "The Streamlined Genome of Phytomonas spp. Relative to Human Pathogenic
RT   Kinetoplastids Reveals a Parasite Tailored for Plants.";
RL   PLoS Genet. 10:e1004007-e1004007(2014).
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
CC   -!- SIMILARITY: Belongs to the cullin family.
CC       {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC       ECO:0000256|RuleBase:RU003829}.
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DR   EMBL; HF955069; CCW62664.1; -; Genomic_DNA.
DR   AlphaFoldDB; W6KM48; -.
DR   EnsemblProtists; CCW62664; CCW62664; GSEM1_T00008290001.
DR   OrthoDB; 21270at2759; -.
DR   Proteomes; UP000027080; Unassembled WGS sequence.
DR   GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR045093; Cullin.
DR   InterPro; IPR016157; Cullin_CS.
DR   InterPro; IPR016158; Cullin_homology.
DR   InterPro; IPR036317; Cullin_homology_sf.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR019559; Cullin_neddylation_domain.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11932; CULLIN; 1.
DR   PANTHER; PTHR11932:SF168; CULLIN-3; 1.
DR   Pfam; PF00888; Cullin; 1.
DR   Pfam; PF10557; Cullin_Nedd8; 1.
DR   SMART; SM00182; CULLIN; 1.
DR   SMART; SM00884; Cullin_Nedd8; 1.
DR   SUPFAM; SSF75632; Cullin homology domain; 1.
DR   SUPFAM; SSF74788; Cullin repeat-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS01256; CULLIN_1; 1.
DR   PROSITE; PS50069; CULLIN_2; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000027080};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   DOMAIN          393..614
FT                   /note="Cullin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50069"
SQ   SEQUENCE   742 AA;  85976 MW;  2D2C32A798B5E816 CRC64;
     MLEEDREAIR RLKADLVRLA DLPDKEFKCH LDPASRMKYY YIVYTAATQN TSKGSEYSGS
     DLGEVLYMDY HEIFTSYLRQ FCDLTAPSEI DLFRKILDVW GRYKVLMNWS MWAFSYLSRY
     YIVNHSKPTL RQVALGIFFE RIFKLHADVL SRVTQDLLIK DTFEHSTNRT LITSAVDLFS
     SLDTCDAQLI YFDRLLHPYI ERLTGEYNKL LQTWCTDTDG IEYLEKIHEA LSNERSRCRE
     YFSKDEEQMI MPSIESTVIS SPIVHSKLIF SDNGFFLALH TRDEIALKKY YDLFSRDKSG
     IKLLSSSVRE EIEIEANKLS HLLQGDEAIV DIVKYLTSMI QLQEGFQRLV VDCFRSDFVI
     SRAVQEGLVR IFNGRVQIKT HHAEQECRIL FCELLANYID VVLQKENGTV KEEIENVVSV
     LMYVIERDYF LLCLKERLLE RIIFPNKAFN EGNEWMFIEN IKQRWGSTST AHLEGMLNDY
     HTSKSFHAAE LLQSLGKTPS LNVSVIFARK GIWPDCLSLK SSLILPYFIE EALNHLQDAY
     LRDMKGRALV WPHEVSNAEL QATYEQGTYI FNVSGIQALI LLSFNTISEQ SIHNIMTVNG
     ISNNQLHQSL PPLTKGKVLL RSNQLSQVED TSERLIVNDN YTACNSKISF PPTLAWTNIV
     NNGQSTPESG NDRKSAIDIC LVRILKSFCT IDHEDLVDEC RKRLKPHFSP DLRLVKHRIE
     ELIQKGYIER DQGNHSKYRY IA
//