ID W6KSJ4_9TRYP Unreviewed; 4145 AA.
AC W6KSJ4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=B30.2/SPRY domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=GSEM1_T00002723001 {ECO:0000313|EMBL:CCW60271.1};
OS Phytomonas sp. EM1.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Phytomonas.
OX NCBI_TaxID=479712 {ECO:0000313|EMBL:CCW60271.1, ECO:0000313|Proteomes:UP000027080};
RN [1] {ECO:0000313|EMBL:CCW60271.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=EM1 {ECO:0000313|EMBL:CCW60271.1};
RA Genoscope - CEA;
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CCW60271.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EM1 {ECO:0000313|EMBL:CCW60271.1};
RX PubMed=24516393; DOI=10.1371/journal.pgen.1004007;
RA Porcel B.M., Denoeud F., Opperdoes F., Noel B., Madoui M.A.,
RA Hammarton T.C., Field M.C., Da Silva C., Couloux A., Poulain J.,
RA Katinka M., Jabbari K., Aury J.M., Campbell D.A., Cintron R., Dickens N.J.,
RA Docampo R., Sturm N.R., Koumandou V.L., Fabre S., Flegontov P., Lukes J.,
RA Michaeli S., Mottram J.C., Szoor B., Zilberstein D., Bringaud F.,
RA Wincker P., Dollet M.;
RT "The Streamlined Genome of Phytomonas spp. Relative to Human Pathogenic
RT Kinetoplastids Reveals a Parasite Tailored for Plants.";
RL PLoS Genet. 10:e1004007-e1004007(2014).
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DR EMBL; HF955062; CCW60271.1; -; Genomic_DNA.
DR EnsemblProtists; CCW60271; CCW60271; GSEM1_T00002723001.
DR OrthoDB; 159333at2759; -.
DR Proteomes; UP000027080; Unassembled WGS sequence.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR CDD; cd11709; SPRY; 1.
DR CDD; cd12885; SPRY_RanBP_like; 1.
DR Gene3D; 2.60.120.920; -; 3.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR042469; HECTD3.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR044736; Vid30/RanBPM/SPLA_SPRY.
DR PANTHER; PTHR46654; E3 UBIQUITIN-PROTEIN LIGASE HECTD3; 1.
DR PANTHER; PTHR46654:SF1; E3 UBIQUITIN-PROTEIN LIGASE HECTD3; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF00622; SPRY; 1.
DR SMART; SM00119; HECTc; 1.
DR SMART; SM00449; SPRY; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF69322; Tricorn protease domain 2; 1.
DR PROSITE; PS50188; B302_SPRY; 2.
DR PROSITE; PS50237; HECT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000027080};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 1919..2121
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 3434..3624
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 3822..4145
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 177..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 4113
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 4145 AA; 464897 MW; 90E81C35129AE14D CRC64;
MHEENSGCLR PMPGPQPELV FNINLLPTEP YANLNNEGLP LHSTTYSAKR CPPARFQDGS
VYIQDSCDAS SNGGGAAKIR SFDMSDFTLS QVYTMGYRSY LHKKKQTDES TFHFPAAPPD
FDGSAPTNLE AVAQYVDRLA IAYKSVRGLP TPFDMYDHII LEAVDNLSNT FMNQIQQANS
TNSPPPRSNA SSHTPPGSSP KEESSSIVLV DQKLSMESFI VSLSLSNLQR MSCREMKILF
DRFQAAPYVA SAVDADVVAS VLTDFHAILM REETPHDTQS HLISLVGMLV SSRSNINEVL
QYLNILEEFH TTYANILPMY VPFASRIIDT FTFHSKSLCP ILSPIDCFQE EDQRLKVNLS
EGTTMQCFCV SSDGKLLAAA TLRGLEVYEV ASGLPVANRE SGAPEGAKSY WSITFSEDLS
SLICSDIAGL NHTVYTIHLN VIEEIHTTEV SIPLDYKSGV MVMQTSPLLP SGSNQSLYFF
ELGSSLAEIE CATSDPKESF TMFAHVHQDF VGTLAHFFTD SGEIVVSVTR CCFKLSQNGA
SCYGIASNNS PWLYVHVRWL KGTWSLDVNA AIVELSGARN DQQKSLVIHK VLCFEGLGHV
GSFALWLDSD DASVVAMYRR ERRLESGTAL VNFPLDEGMG LWVKETVSCT AFTIPEAHCA
WDENVLVPCI SSPEEDVPGK KSNVCMDPKL LLESKTLSSS FKIYMILPSR VKGGDDIVIV
VDRATRKITR VSHCPRSCSE NIYALLSDES KLFVYQQRFS AFSSVRLHSM QCKLSELASS
GLLDATLPVN SIRWFRHEWY KKIYMEVFEL HRIPLANTPL SFTNLFALAD SFKNIKASTD
KLYVVAILSL TLVHFQMLIS ADEKHISRIA TLLKSSCKQI MEMFPEKIIN EAAHELLNAA
TCKSLTLSDK VQALLDPDMQ RSAATLKLYV TKESLFTLIH HIVTHSPAVL TDVARRLISM
ARAEAASSSS TAVAKPITRL MTSFVLLCVK ELMAYDGFDE ISQLVELFVE FVEQELPKAG
TGVQMQNTTL HTGCIPLFIV VAHFCPWVLT PKIEEGLLNI MHALKGKFGD KEVVSFTTRE
ACYVFPPNRE REAMWRFAID LSDASSVAVQ KESHMPSLSI IRSDSTALHR NKIEMSRERT
FLKLEGGQLI FFGSGENNFT INAQFDFCVP TSWESTLSDC IHNLLVSHAR HLIHKPKTND
VFVPPMLRHG LNADALCRHG IKLDIREPQK TTFAFDILNN VGGGKAFVDQ VYQSMRGSIV
PSMRPAIQAL LAILIHAGVN AQQAEDELKL RWFSGEWGVK LQGPNRDVTR TFLSDFANWF
ISSVYYQMEG TVVTFRRGSF DRRLENSLNN SRSISERHRS TSSRRSIFKH SQQSDTLDQL
KTLFAREVTP AVLEAVLVER TQAALKIVHS ISLLRKLLRL EDLEQTSEAS TLSVLDVLSS
FVNVESGTHY IESLSGAGFD LQMQVRMSLH SVLVRCQELL LGRCPKNIAP QAVLTERATN
GTATMQLLSI LCHPFDALDA EIFNANFGNE NDVLKQLENH ICILTTNLMQ MNPWDLHKDN
GSDSSALEDR EFRFEPMGEV DLNSISCIYP NDFTIVIPQL QASRSEEGVL IENNNINSVE
LSADEGWPLA WKDGLPRVFY YEVKIKSLVC KLDVGLTVSR LSFGMVRLDS LYFYSSSGET
HSVSFPMFGE DDTVGCGFIS TNRRIFFTLN GVLLGLMDTV PDKQDILFPT LRFSERSGAK
VLVNFGTSTF AYDYQQLHPA LNLRRGPTWY RVASTAATTL HHIAARACLM QEARKSSASV
FLTHCFEVVC RNVSKVTTFL MNTGIGSADH SDSHTRIKQS VIFAVAEYSI MLLIATIRHI
VNTGALYNPL PEVVGEMIFD AVSVLMLLPL RSTQVAVISV LPEIIPHVRH QPDGNALANL
VRTLFRHAND PAAESPHIIP FTPTWCECDP RFMSIVNVQS ACMSPESQRS IVLGNVLPRT
GVVSFSVKIN RRNMSKGHSL KGGYFIGVSV TRLSPLSPTS NSQSWKTVKP PIVWAMHDTS
PQLPHATNPI VKANNFQRTF GNDDMIRVVV DRDNRTVDFY RDDELLRTLF SNLPADIDLV
PFVQLYNDDA SVTIYPGEMT SPISTSTLLS AASVDVLRAM LMLEPFQFLV AKGLCNELDM
HAYPKVTLAL FNSLPDRRML QLRSRTGEEF FITVSRVGDM RCKFSIGNEA NYEHLYNLHT
PANPKITCSL DTQNLSGSSG GLALCIGRLV AAVRRIVLPF ITTQALSALE HEQRLKIIDE
EKERWDFLFH GLRVGTFINI QRSSQMKAIF PTPNTPIDYT FSAAMSHPSF SMPRTYCGRL
ATIPSGSENI TTPFITIADP AVPLQGTFSI RCQLIRGHNG QILGGGYYFG LCTSSFNWKR
KDLNSGVPEV WAIHDMDDAP WRLRHFSPTC TLPIAADPRC VIVSGDIIRL EINRDEGTMR
AFRKPFDGDE ISFGIIFDNL PKGNLHPFVH LFNMDSVAVL LPSKNMDSAL RFTVQQPLFS
TYSFNERRYC DGCAAQHVES RLGKQWYKCV ECADYALCKD CFDLCVHSHH TFTDMGAYSL
VHTKTPPKKI IKGMQVVIPS TSCMYLRSSG CRMDEECINC VAESIEDNSF AIWGLVCKGR
AHFTASIETL DNRPLRADRL VFIGVGLTNE IMQLSREKLL NRCFTPSSSI LTYCNYYSMR
RRVNGENRHS HGFDNGSTIT IDIDVIKRTA TFIRDWIVVD TCPIEFLTSG SNHYVALCFF
VVFEKKGVKI MIRPDSGMTM TARVEEANGS IVKVSAPDSR IRYVTTENCR LPLRQCEVAP
AIGRLGYTYI DKRLVQCRVV ALEKGEVKLR LVKDDCIHKV SLYHFLVDEH DAIADEHLIQ
KESDENGATL LDGFVVSRLL LILSCLCEKE ELSPLVIQHG TELINLIKGL ASVQISNYTP
LNFLSEIRTL IAETASAVQW FNPTQRLGSF VPTLGIDDRK RRFKPGMLVQ CTTTGGSQEV
YRVVSRKGEM LTLVHLMTLE SMEIPHKNCI PVKQSNGKPW YKVNNGLPCS FREHTIRLTQ
PNSGSRSVSI EGVWQGEFAF PKSKAILFDM TLDNSGTGTA LLNIHGHKVG YRAIYGHIEY
QRIVYLCLTR DDPPGKNTPY QIVNTENVVS YVRKMHQVMS ALTLSDATDC YMAELSVDAE
GLCMSGVCCH SNGKTGSLVC YCPDRPLLIS SHTDMAHIEP LPDCVDTITM TKPLRSLSET
IHRLVILLAR HLYLVICSKK NIISRELVEN VFLFNTHPLT DRLITRFVDI HQLFLMISDA
SQRITNPDVK PWDAATLSTL ITKTLLLRPE SLTKAPQSLI WDSLHAVVVA MHRCGCQFRH
DILRKVTAFV RSHRDTEQRL YWQLFGALVT YFDRNTFSST ARLDDIHKDV AAGVDLILSF
RPQEPWHLRN IPTQPLHCLV DLWRSLVEDR PLPHVVDETN DPHGDSDLNV DVVCAFGDYS
DEELKVGKVM SSISAVRSGQ YYYEVILPDR LISPFAVGWG TQAHCEVPSQ HVGSDRTSFS
FNGSEVSTKD TKEDYKVAQE ITPGCVLGCL LRMEEQVVAW SINGTLGPFI SIPITPSDKG
LYAFVSTGIC SGLRVRLRAS EFEFVPDGYT DLAGHYTRVL IATYDESVRS SLPVQSLSFY
SQVASYYSDV TEYKKEDKKS LMEASMSATF MLRVAVNNLF LPKYPALVGL SEDTLKAHER
VIETVESCMA TASRFVDLDS DVISGTLSMA FLYLKPLVRR SFRQKLLINI PGVEKATSPP
TISIRITELF STLPRTPDVA LHHTVLSQLY RQIGGFTEEQ WSQSPLFKVN LYISGSGHAP
IDMGGPYRQV WTFLAEELVR HPDKCYPHSD FHRNPLFCFV DNSQRVSLVP DNLANSSLEL
TLFNFFGKIM GHAARAHLPL NIDFSPFLWK FLVDDALSVK DYYKYVDGVV ENSMEDDNFL
LSGVAEEIIP NFAENVMWLD EEELKGQRIV EHRRRIAENC LVHSMDEQLN AIRCGLWSIL
PRRVVRCLSW CDLERLVCGE SNPTIKELRR YIHTQLNPVR EKYFWKILEE FTAEEKAALL
CFSSGQRRLP LIRQIIIQEN NESVEHLPRA QSCSSLVTIP PYTSLEMFRE KLLLALQHQD
EMELA
//
