ID   W6KSX1_9TRYP            Unreviewed;      1005 AA.
AC   W6KSX1;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal domain-containing protein {ECO:0000259|SMART:SM00839};
GN   ORFNames=GSEM1_T00006011001 {ECO:0000313|EMBL:CCW65295.1};
OS   Phytomonas sp. EM1.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Phytomonas.
OX   NCBI_TaxID=479712 {ECO:0000313|EMBL:CCW65295.1, ECO:0000313|Proteomes:UP000027080};
RN   [1] {ECO:0000313|EMBL:CCW65295.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=EM1 {ECO:0000313|EMBL:CCW65295.1};
RA   Genoscope - CEA;
RL   Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CCW65295.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EM1 {ECO:0000313|EMBL:CCW65295.1};
RX   PubMed=24516393; DOI=10.1371/journal.pgen.1004007;
RA   Porcel B.M., Denoeud F., Opperdoes F., Noel B., Madoui M.A.,
RA   Hammarton T.C., Field M.C., Da Silva C., Couloux A., Poulain J.,
RA   Katinka M., Jabbari K., Aury J.M., Campbell D.A., Cintron R., Dickens N.J.,
RA   Docampo R., Sturm N.R., Koumandou V.L., Fabre S., Flegontov P., Lukes J.,
RA   Michaeli S., Mottram J.C., Szoor B., Zilberstein D., Bringaud F.,
RA   Wincker P., Dollet M.;
RT   "The Streamlined Genome of Phytomonas spp. Relative to Human Pathogenic
RT   Kinetoplastids Reveals a Parasite Tailored for Plants.";
RL   PLoS Genet. 10:e1004007-e1004007(2014).
CC   -!- SIMILARITY: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
CC       {ECO:0000256|ARBA:ARBA00006382}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; HF955104; CCW65295.1; -; Genomic_DNA.
DR   AlphaFoldDB; W6KSX1; -.
DR   EnsemblProtists; CCW65295; CCW65295; GSEM1_T00006011001.
DR   OrthoDB; 89313at2759; -.
DR   Proteomes; UP000027080; Unassembled WGS sequence.
DR   GO; GO:0004352; F:glutamate dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR   InterPro; IPR006096; Glu/Leu/Phe/Val/Trp_DH_C.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR11606; GLUTAMATE DEHYDROGENASE; 1.
DR   PANTHER; PTHR11606:SF42; NAD-SPECIFIC GLUTAMATE DEHYDROGENASE; 1.
DR   Pfam; PF00208; ELFV_dehydrog; 1.
DR   SMART; SM00839; ELFV_dehydrog; 1.
DR   SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000027080}.
FT   DOMAIN          619..900
FT                   /note="Glutamate/phenylalanine/leucine/valine/L-tryptophan
FT                   dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00839"
SQ   SEQUENCE   1005 AA;  113207 MW;  4BB8717A5EB9CF2E CRC64;
     MMRRIAFRVA AVSRPVTVSA SVLPSMYRGV STTPTLEMDK IMSKIKSEGI FDTPMIKDTL
     SRFVNSLSST TYLKHVTPEE VSNHVLGVLN AEASQKMGNA YEFAREDNHS AFYICKNEPE
     SIIRNVRRMA KYTSRPDIPE NHSVVVRSFH AENPSMVIYT VSFVPFDVPK PDESETKAEK
     LIPKQLLKNL SEEKLKRLQR LLDRRPNSVF PVIDTVEDSR SKDTILFTMA TCADKTNYIV
     SLLNVFQEIK GSEVIRVSTC TLVSGDRVYS MIIKGATLEQ VKEQASMVGL LSSKAAKPIV
     RMYESGMLTC EQAVYIDAAF IFSFYFTQIP VDDTYRHLRT VLENVPHGIN WLNSMRNSLA
     QETMSEHYMG SLIENYPQFV QLIYEDFQKG STAERRASIA EQIVQKLADD GRLPHDVAIF
     MSLLKFNEVV LKHNFFKTEK AALAFRLDPS FLKDLEYPLV PHGVFLFAGG HWRGFHIRFT
     DIARGGVRLI VSKPNTYSKN KRTVFQENYN LAFTQLLKNK DIPEGGSKGT ILVSSRFLTA
     FDEAACKRIF LQYVDAMLDL MIPGEPGIVN RLGQDEIIFL GPDEYTAGSF PSAGALHSKK
     RGYVNWKSFT TGKDPDMGGI PHDVYGMTTR SVRTFVNAIY RELGLDGSKM RKFQTGGPDG
     DLGSNEILMS NEVLIGVVDG SASLHDPNGL NREELLRLAC GRMPLAKFDR SKLSKDGFLV
     LVDDVNVTLP DGTLVKKGVQ LRDEFHFLKY SDADVFVPCG GRPRSITLEN VARLLKMKGV
     DGEDMLQGRV NPTPSQLKYK IIVEGANLFI SQDARLALER CGVVLIKDAS SNKGGVTSSS
     LEVFAGLCLS DEEHAKYMCV RDELNPPLFY KRLVEEIVAR IEKNAENEFN AIWSEWKKDP
     SKPKTLIADA LSSKSVKIRA DILKSDIFAD KKLVRHVMME YAPKTLLEVV PIDKMLQRVP
     EVYQHAICAM WLSSNYVFSG RANSNEFDFF KFLTEEIKRM NAKYE
//