ID W6LEQ9_9TRYP Unreviewed; 987 AA.
AC W6LEQ9;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=GSHART1_T00004870001 {ECO:0000313|EMBL:CCW68171.1};
OS Phytomonas sp. Hart1.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Phytomonas.
OX NCBI_TaxID=223615 {ECO:0000313|EMBL:CCW68171.1, ECO:0000313|Proteomes:UP000053358};
RN [1] {ECO:0000313|EMBL:CCW68171.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Hart1 {ECO:0000313|EMBL:CCW68171.1};
RA Genoscope - CEA;
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CCW68171.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hart1 {ECO:0000313|EMBL:CCW68171.1};
RX PubMed=24516393; DOI=10.1371/journal.pgen.1004007;
RA Porcel B.M., Denoeud F., Opperdoes F., Noel B., Madoui M.A.,
RA Hammarton T.C., Field M.C., Da Silva C., Couloux A., Poulain J.,
RA Katinka M., Jabbari K., Aury J.M., Campbell D.A., Cintron R., Dickens N.J.,
RA Docampo R., Sturm N.R., Koumandou V.L., Fabre S., Flegontov P., Lukes J.,
RA Michaeli S., Mottram J.C., Szoor B., Zilberstein D., Bringaud F.,
RA Wincker P., Dollet M.;
RT "The Streamlined Genome of Phytomonas spp. Relative to Human Pathogenic
RT Kinetoplastids Reveals a Parasite Tailored for Plants.";
RL PLoS Genet. 10:e1004007-e1004007(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC {ECO:0000256|ARBA:ARBA00008792}.
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DR EMBL; HF955201; CCW68171.1; -; Genomic_DNA.
DR AlphaFoldDB; W6LEQ9; -.
DR EnsemblProtists; CCW68171; CCW68171; GSHART1_T00004870001.
DR OrthoDB; 5490433at2759; -.
DR Proteomes; UP000053358; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd17982; DEXHc_DHX37; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF99; ATP-DEPENDENT RNA HELICASE DHX37-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000053358}.
FT DOMAIN 177..368
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 398..679
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 71..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 460..485
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 501..530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 987 AA; 111397 MW; CDBE5FE5187CF3F0 CRC64;
MQRKKSISFN DLGLTTPLPI TLAKSREQRH LEKLEGKKQK KLLVKEATAC VSSLRTDVEK
HKAFISTEFK NEKDEKEKRK KKLQAEHIKA RNERETKKER DALSIEAQHK YISEIMEMQR
EDNTRMRQVQ LLLEKAQEKS IKEAIANVHI PVIRSKIIEE QRARLPVLRE EQPIIEAINN
ATRTCVLICG ETGSGKTTQI PQFLWETGYG HAESQAFGRE GCILVTEPRR VAAVSMAQRV
AEELNQPFGQ EVCYHVRYNN NLSDTCRLKF ATEGIVLKEI QSDFLLTQYS VIVVDEAHER
SISCDILVGL LSRIVPLRND LFHEELEANG RDASKTKIKP LRLVIMSATM RVQDFRDNRV
LFPIVPPLIN VEARLFPVTN HFARKTILID YVQQSFEKVC QIHKKLPPGG ILVFLCTQHE
IEDLCACLRE HYAKTKVEYN EHTYNKHAFL RGTSGGFPKM LEQDDASSSA SVDGTIPDGD
VTNEKTQDEY GLFIDEYALD EDESTGGDTP GGISEATMSE NKFKRPRKAG TTSNFKIEEE
DEPNGKFDTL HVLPLYALLD LKKQHEVFKA PPPGKRLCVV ATNVAETSIT IPNIKYVVDA
GRAKTKVIDE ETKASCFSIE WISQASAEQR SGRAGRVGPG HCYRLYSTAV YSNLMAKYGT
PEILRTPLDS VVLLMKHIGI DHVGAFAFPS PPRLDDLKGA LSHLTLLEAL DGSNGYRITP
LGRKLIAYPI PPRFARAVVE AQSMQLSQKL LGMVLLIVAV CATTTHIFTG EGNQIKASKK
DEGDPRRERI RSLLNHGSDL LTYLNAFHVY MQNPKNCHTY CLVDKSMHES KMLFRQLRNL
VEENSTAEGD LMDSLDTNET WYIGNTAGCT TERVQITKDD EIALRQVFIP GLLDQVARRA
TVHECRSMNV EYTDRKTSAT PYLVTSTHSI VYINPTSSVS RTYPAPEYVT YTALQKVVRS
ETKKAQACML GVTVVTKEWL NLYDYSE
//
