ID W6NRH7_HAECO Unreviewed; 415 AA.
AC W6NRH7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=SH2 motif and Protein kinase C and RhoGAP domain containing protein {ECO:0000313|EMBL:CDL94777.1};
GN ORFNames=HCOI_00487100 {ECO:0000313|EMBL:CDL94777.1};
OS Haemonchus contortus (Barber pole worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Trichostrongylidae; Haemonchus.
OX NCBI_TaxID=6289 {ECO:0000313|EMBL:CDL94777.1};
RN [1] {ECO:0000313|EMBL:CDL94777.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISE/inbred ISE {ECO:0000313|EMBL:CDL94777.1};
RA Aslett M.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CDL94777.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISE/inbred ISE {ECO:0000313|EMBL:CDL94777.1};
RA Laing R., Kikuchi T., Martinelli A., Tsai I.J., Beech R.N., Redman E.,
RA Holroyd N., Bartley D.J., Beasley H., Britton C., Curran D., Devaney E.,
RA Gilabert A., Jackson F., Hunt M., Johnston S., Kryukov I., Li K.,
RA Morrison A.A., Reid A.J., Sargison N., Saunders G., Wasmuth J.D.,
RA Wolstenholme A., Berriman M., Gilleard J.S., Cotton J.A.;
RT "The genome and transcriptome of Haemonchus contortus: a key model parasite
RT for drug and vaccine discovery.";
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDL94777.1}.
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DR EMBL; CAVP010058503; CDL94777.1; -; Genomic_DNA.
DR AlphaFoldDB; W6NRH7; -.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd20806; C1_CHN; 1.
DR CDD; cd00159; RhoGAP; 1.
DR CDD; cd10352; SH2_a2chimerin_b2chimerin; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR035840; Chimaerin_SH2.
DR InterPro; IPR020454; DAG/PE-bd.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR PANTHER; PTHR46075; CHIMERIN FAMILY MEMBER; 1.
DR PANTHER; PTHR46075:SF2; RHO GTPASE ACTIVATING PROTEIN AT 5A, ISOFORM A; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00008; DAGPEDOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:CDL94777.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Transferase {ECO:0000313|EMBL:CDL94777.1};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 51..120
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 166..216
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 229..413
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
SQ SEQUENCE 415 AA; 47427 MW; 38B899FC38528B22 CRC64;
MEDDTGGTGG SIGGLGYWKQ NLYLLQERAP KPSAVKCNRF IENRPPQYGS EFHGLIDRVE
ADRMLMEAGE GAFLVRESKR SQDAFTLCML FDGRVLNYKL YYDGTHYVGE KRFETMELLV
ADGLISMFMD KHASDYIKRM ADEAIYEHSP YMQYTKSSER KPVARSHSFA QYTFKMPHYC
DYCRNFMWGL VQQGVRCEDC GFAAHKRCSE HTLPDCRPEA RYVKRMFAVD LTTLCLAHST
PIPPVVTKCI NEVEARGLNV EGIYRVSGSH EHMEKLKRQF DSQQSVDLNQ VDDIHTVCGL
LKLYLRLLPQ QLVPFSVYKA LLVAFANSRS VHEKTRACRK ALEELSEANA VTLNALLIHL
RKVAEHSAQN KMSVENISTI FSPTLFCTGV VPSLPQQQHM LLHFMIRTPR IVPYV
//
