ID   W6NS81_HAECO            Unreviewed;       267 AA.
AC   W6NS81;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   SubName: Full=Peptidase A1 domain containing protein {ECO:0000313|EMBL:CDL94987.1};
GN   ORFNames=HCOI_01286600 {ECO:0000313|EMBL:CDL94987.1};
OS   Haemonchus contortus (Barber pole worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Trichostrongylidae; Haemonchus.
OX   NCBI_TaxID=6289 {ECO:0000313|EMBL:CDL94987.1};
RN   [1] {ECO:0000313|EMBL:CDL94987.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISE/inbred ISE {ECO:0000313|EMBL:CDL94987.1};
RA   Aslett M.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CDL94987.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISE/inbred ISE {ECO:0000313|EMBL:CDL94987.1};
RA   Laing R., Kikuchi T., Martinelli A., Tsai I.J., Beech R.N., Redman E.,
RA   Holroyd N., Bartley D.J., Beasley H., Britton C., Curran D., Devaney E.,
RA   Gilabert A., Jackson F., Hunt M., Johnston S., Kryukov I., Li K.,
RA   Morrison A.A., Reid A.J., Sargison N., Saunders G., Wasmuth J.D.,
RA   Wolstenholme A., Berriman M., Gilleard J.S., Cotton J.A.;
RT   "The genome and transcriptome of Haemonchus contortus: a key model parasite
RT   for drug and vaccine discovery.";
RL   Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase A1 family.
CC       {ECO:0000256|ARBA:ARBA00007447}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDL94987.1}.
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DR   EMBL; CAVP010058637; CDL94987.1; -; Genomic_DNA.
DR   AlphaFoldDB; W6NS81; -.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   CDD; cd05471; pepsin_like; 1.
DR   Gene3D; 2.40.70.10; Acid Proteases; 1.
DR   InterPro; IPR001461; Aspartic_peptidase_A1.
DR   InterPro; IPR034164; Pepsin-like_dom.
DR   InterPro; IPR033121; PEPTIDASE_A1.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR   PANTHER; PTHR47966:SF71; PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00026; Asp; 1.
DR   SUPFAM; SSF50630; Acid proteases; 1.
DR   PROSITE; PS51767; PEPTIDASE_A1; 1.
PE   3: Inferred from homology;
FT   DOMAIN          1..262
FT                   /note="Peptidase A1"
FT                   /evidence="ECO:0000259|PROSITE:PS51767"
SQ   SEQUENCE   267 AA;  28781 MW;  6EBE4050AC3D942B CRC64;
     MASNHFGLTE GSYGMDTLRL ATDDADMIVI TFTVMGQVNV MPAAVSALNG VDGVLGLAFQ
     SIASDTLISP PFIRGVAQGE IAQSVFSIWL EEQWQTSDNG THGVIYYGGY DLVHCRPDRG
     SVQLSAAGLY QFTLPNFYIN GTGAAKKIQT TIISSSPYIK VPPALFMQIL YSVNVNYETP
     LPAKVDCSVK LSLGFDVGGS FGYLMVTERN LILSNNDGTC TLAVMPTDAD GFDMGQNIQL
     GIPFLRGRCT YFDTGLQRLG FADAIQH
//